Effects of eldecalcitol on the pharmacokinetics of the CYP3A4 substrate, simvastatin - Double blind, randomized, placebo-controlled, parallel group comparative study in healthy male volunteers

Japanese Pharmacology and Therapeutics

Volumn 39, Issue 3, 2011, Pages 275-285

  Miyata, Kumiko ^a   Ohba, Yasuhiro ^a   Abe, Masaichi ^a   Terao, Kimio ^a   Kawanishi, Takehiko ^a   Ohnishi, Akihiro ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Active vitamin D3; CYP3A4; Drug interaction; Edirol; Eldecalcitol; Osteoporosis; Simvastatin

Indexed keywords

CYTOCHROME P450 3A4; DRUG METABOLITE; ELDECALCITOL; HYDROXYACID; PLACEBO; SIMVASTATIN; SIMVASTATIN HYDROXYACID; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE COUNT; MALE; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 79955392940     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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