Twin screw wet granulation: Effect of powder feed rate

Advanced Powder Technology

Volumn 22, Issue 2, 2011, Pages 162-166

  Dhenge, Ranjit M ^a   Cartwright, James J ^b   Doughty, David G ^b   Hounslow, Michael J ^a   Salman, Agba D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Continuous; Granulation; Granule structure; Strength; Twin screw granulator

Indexed keywords

CONTINUOUS; GRANULE FORMATIONS; GRANULE PROPERTIES; GRANULE STRUCTURE; KINETICS AND MECHANISM; POWDER FEED RATE; PROCESS VARIABLES; STRENGTH; TWIN SCREW; TWIN SCREW EXTRUDERS; TWIN SCREW GRANULATOR; WET GRANULATION; WET GRANULATION TECHNIQUE; WORK FOCUS;

DISSOLUTION; GRANULATORS; GROWTH KINETICS; PRODUCT DESIGN; SCREWS; SURFACE STRUCTURE;

GRANULATION;

EID: 79955391839     PISSN: 09218831     EISSN: 15685527     Source Type: Journal    
DOI: 10.1016/j.apt.2010.09.004     Document Type: Article

References (10)

1. B. Ennis, J. Litser, T. Allen, and R.H. Snow Perry's, Chemical Engineer's Handbook Chapter 20: Size Reduction and Size Enlargement seventh ed. 1997 McGraw Hill New York
2. L. Lachman, and H. Sylwestrowicz Experiences with unit-to-unit variations in tablets Journal of Pharmaceutical Sciences 53 1964 1234 1242
3. P.C. Kapur, and D.W. Fuerstenau Coalescence model for granulation Industrial and Engineering Chemistry Process Design and Development 8 1 2002 56 62
4. E.I. Keleb, A. Vermeire, C. Vervaet, and J.P. Remon Continuous twin screw extrusion for the wet granulation of lactose International Journal of Pharmaceutics 239 1-2 2002 69 80 (Pubitemid 34615796)
5. R.M. Dhenge, R.S. Fyles, J.J. Cartwright, D.G. Doughty, M.J. Hounslow, A.D. Salman, Twin screw wet granulation: granule properties. Chemical Engineering Journal (2010), in press, doi:10.1016/j.cej.2010.05.023.
6. D. Djuric, B. Van Melkebeke, P. Kleinebudde, J.P. Remon, and C. Vervaet Comparison of two twin-screw extruders for continuous granulation European Journal of Pharmaceutics and Biopharmaceutics 71 1 2009 155 160
7. E.I. Keleb, A. Vermeire, A. Vervaet, C. Remon, and J.P. Twin Twin screw granulation as a simple and efficient tool for continuous wet granulation International Journal of Pharmaceutics 273 1-2 2004 183 194 (Pubitemid 38317051)
8. C. Nikitine, E. Rodier, M. Sauceau, and J. Fages Residence time distribution of a pharmaceutical grade polymer melt in a single screw extrusion process Chemical Engineering Research and Design 87 6 2009 809 816
9. F. Langenbucher Parametric representation of dissolution-rate curves by the RRSBW distribution Pharmaceutical Industries 38 1976 472 477
10. M.J. Adams, M.A. Mullier, and J.P.K. Seville Agglomerate strength measurement using a uniaxial confined compression test Powder Technology 78 1 1994 5 13