The transcriptional Mediator component Med12 is required for hindbrain boundary formation

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Hong, Sung Kook ^a,b   Dawid, Igor B ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEDIATOR COMPLEX; MEDIATOR COMPLEX 12; UNCLASSIFIED DRUG; MED12 PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL DEATH; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO SEGMENTATION; GENE MUTATION; MARKER GENE; NEUROMERE; NONHUMAN; RHOMBENCEPHALON; ZEBRA FISH; ANIMAL; CYTOLOGY; GENETICS; MORPHOGENESIS; MUTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT;

DANIO RERIO;

ANIMALS; BODY PATTERNING; CELL PROLIFERATION; MEDIATOR COMPLEX; MUTATION; RHOMBENCEPHALON; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 79955366507     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019076     Document Type: Article

References (46)

1. Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW, (2005) The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci 30: 250-255.
2. Malik S, Roeder RG, (2010) The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 11: 761-772.
3. Malik S, Roeder RG, (2005) Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci 30: 256-263.
4. Bjorklund S, Gustafsson CM, (2005) The yeast Mediator complex and its regulation. Trends Biochem Sci 30: 240-244.
5. Bourbon HM, (2008) Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res 36: 3993-4008.
6. Hong SK, Haldin CE, Lawson ND, Weinstein BM, Dawid IB, et al. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A 102: 18473-18478.
7. Shin CH, Chung WS, Hong SK, Ober EA, Verkade H, et al. (2008) Multiple roles for Med12 in vertebrate endoderm development. Dev Biol 317: 467-479.
8. Rau MJ, Fischer S, Neumann CJ, (2006) Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Dev Biol 296: 83-93.
9. Wang X, Yang N, Uno E, Roeder RG, Guo S, (2006) A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A 103: 17284-17289.
10. Rocha PP, Scholze M, Bleiss W, Schrewe H, (2010) Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137: 2723-2731.
11. Ding N, Zhou H, Esteve PO, Chin HG, Kim S, et al. (2008) Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell 31: 347-359.
12. Philibert RA, Madan A, (2007) Role of MED12 in transcription and human behavior. Pharmacogenomics 8: 909-916.
13. Risheg H, Graham JM Jr, Clark RD, Rogers RC, Opitz JM, et al. (2007) A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Nat Genet 39: 451-453.
14. Lumsden A, Krumlauf R, (1996) Patterning the vertebrate neuraxis. Science 274: 1109-1115.
15. Trainor PA, Krumlauf R, (2000) Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nat Rev Neurosci 1: 116-124.
16. Fraser S, Keynes R, Lumsden A, (1990) Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344: 431-435.
17. Guthrie S, Lumsden A, (1991) Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development 112: 221-229.
18. McKay IJ, Muchamore I, Krumlauf R, Maden M, Lumsden A, et al. (1994) The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres. Development 120: 2199-2211.
19. Moens CB, Yan YL, Appel B, Force AG, Kimmel CB, (1996) valentino: a zebrafish gene required for normal hindbrain segmentation. Development 122: 3981-3990.
20. Lecaudey V, Anselme I, Rosa F, Schneider-Maunoury S, (2004) The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain. Development 131: 3121-3131.
21. Maves L, Kimmel CB, (2005) Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev Biol 285: 593-605.
22. Schneider-Maunoury S, Topilko P, Seitandou T, Levi G, Cohen-Tannoudji M, et al. (1993) Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell 75: 1199-1214.
23. Cooke JE, Kemp HA, Moens CB, (2005) EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish. Curr Biol 15: 536-542.
24. Cooke JE, Moens CB, (2002) Boundary formation in the hindbrain: Eph only it were simple. Trends Neurosci 25: 260-267.
25. Kemp HA, Cooke JE, Moens CB, (2009) EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel. Dev Biol 327: 313-326.
26. Xu Q, Mellitzer G, Robinson V, Wilkinson DG, (1999) In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature 399: 267-271.
27. Cheng YC, Amoyel M, Qiu X, Jiang YJ, Xu Q, et al. (2004) Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Dev Cell 6: 539-550.
28. Qiu X, Lim CH, Ho SH, Lee KH, Jiang YJ, (2009) Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries. Dev Genes Evol 219: 339-351.
29. Amoyel M, Cheng YC, Jiang YJ, Wilkinson DG, (2005) Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development 132: 775-785.
30. Riley BB, Chiang MY, Storch EM, Heck R, Buckles GR, et al. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev Dyn 231: 278-291.
31. Blair SS, (2004) Developmental biology: Notching the hindbrain. Curr Biol 14: R570-572.
32. Moens CB, Cordes SP, Giorgianni MW, Barsh GS, Kimmel CB, (1998) Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Development 125: 381-391.
33. Kelly GM, Erezyilmaz DF, Moon RT, (1995) Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin. Mech Dev 53: 261-273.
34. Thisse B, Pflumio S, Fürthauer M, Loppin B, Heyer V, et al. (2001) Expression of the zebrafish genome during embryogenesis.: ZFIN Direct Data Submission.
35. McClintock JM, Kheirbek MA, Prince VE, (2002) Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development 129: 2339-2354.
36. Hernandez RE, Putzke AP, Myers JP, Margaretha L, Moens CB, (2007) Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. Development 134: 177-187.
37. Nittenberg R, Patel K, Joshi Y, Krumlauf R, Wilkinson DG, et al. (1997) Cell movements, neuronal organisation and gene expression in hindbrains lacking morphological boundaries. Development 124: 2297-2306.
38. Picker A, Scholpp S, Bohli H, Takeda H, Brand M, (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development 129: 3227-3239.
39. Sassa T, Aizawa H, Okamoto H, (2007) Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems. Dev Dyn 236: 706-718.
40. Matsuda M, Chitnis AB, (2009) Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue. Development 136: 197-206.
41. Bierkamp C, Campos-Ortega JA, (1993) A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis. Mech Dev 43: 87-100.
42. Dahmann C, Oates AC, Brand M, (2011) Boundary formation and maintenance in tissue development. Nat Rev Genet 12: 43-55.
43. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF, (1995) Stages of embryonic development of the zebrafish. Dev Dyn 203: 253-310.
44. Kudoh T, Tsang M, Hukriede NA, Chen X, Dedekian M, et al. (2001) A gene expression screen in zebrafish embryogenesis. Genome Res 11: 1979-1987.
45. Toyama R, O'Connell ML, Wright CV, Kuehn MR, Dawid IB, (1995) Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development 121: 383-391.
46. Hauptmann G, Gerster T, (1994) Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Trends Genet 10: 266.