Parenteral insulin suppresses T cell proliferation to islet antigens

Pediatric Diabetes

Volumn 12, Issue 3 PART 1, 2011, Pages 150-155

  Greenbaum, Carla J ^a   Mcculloch Olson, Marli ^a   Chiu, Harvey K ^b   Palmer, Jerry P ^c   Brooks Worrell, Barbara ^c  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b SEATTLE CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Diabetes prevention trial; T cell; Type 1 diabetes

Indexed keywords

ANTIGEN; INSULIN;

ADOLESCENT; ADULT; ANTIGEN DETECTION; ARTICLE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; LYMPHOCYTE PROLIFERATION; PANCREAS ISLET; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOLESCENT; ADULT; AUTOANTIBODIES; CELL DIVISION; CHILD; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; INSULIN; ISLETS OF LANGERHANS; PARENTS; RISK FACTORS; T-LYMPHOCYTES; YOUNG ADULT;

EID: 79955365596     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2010.00674.x     Document Type: Article

References (16)

1. Greenbaum CJ, Harrison LC. Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes. Diabetes 2003: 52: 1059-1065.
2. Brooks-Worrell B, Gersuk VH, Greenbaum C, Palmer JP. Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes. J Immunol 2001: 166: 5265-5270.
3. Brooks-Worrell BM, Starkebaum GA, Greenbaum C, Palmer JP. Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. J Immunol 1996: 157: 5668-5674.
4. Herold KC. Type 1 Diabetes TrialNet study group. Report of the TrialNet T cell validation study in Type 1 diabetes. American Diabetes Association, Scientific Sessions, Chicago, IL; Abstract 1229, 2007.
5. Seyfert-Margolis V, Gisler TD, Asare AL et al. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 2006: 55: 2588-2594.
6. Diabetes Prevention Trial Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002: 346: 1685-1691.
7. Herold KC, Brooks-Worrell B, Palmer J et al. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes: 2009: 58: 2588-2595.
8. Brooks-Worrell BM, Pihoker C, Greenbaum CJ, Palmer JP. Presence of islet reactive T cells and autoantibodies in children diagnosed clinically with either type 1, type 2, or a typical diabetes. 4th Immunology of Diabetes Society, Rome, Italy1999.
9. Hao W, Lindsong L, Mehta V, Lernmark A, Palmer J. The functional state of the beta cell affects expression of both forms of glutamic acid decarboxylase. Autoimmunity 1993: 15: 73.
10. McCulloch DK, Barmeier H, Neifing JL, Palmer JP. Metabolic state of the pancreas affects end-point titre in the islet cell antibody assay. Diabetologia 1991: 34: 622-625.
11. Tiittanen M, Huupponen JT, Knip M, Vaarala O. Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro. Diabetes 2006: 55: 3446-3454.
12. Jacobs MJ, van den Hoek AE, van de Putte LB, van den Berg WB. Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance. Immunology 1994: 82: 294-300.
13. Lagrange PH, Mackaness GB, Miller TE. Influence of dose and route of antigen injection on the immunological induction of T cells. J Exp Med 1974: 139: 528-542.
14. Lelchuk R, Carrier M, Kahl L, Liew FY. Distinct IL-3 activation profile induced by intravenous versus subcutaneous routes of immunization. Cell Immunol 1989: 122: 338-349.
15. Mukasa A, Itoh M, Tokunaga Y, Hiramine C, Hojo K. Inhibition of a novel model of murine experimental autoimmune orchitis by intravenous administration with a soluble testicular antigen: participation of CD8+ regulatory T cells. Clin Immunol Immunopathol 1992: 62: 210-219.
16. Myers LK, Stuart JM, Seyer JM, Kang AH. Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis. J Exp Med 1989: 170: 1999-2010.