-
1
-
-
77953237514
-
Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment
-
Liu Y, Wu F (2010) Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 118(6): 818-824.
-
(2010)
Environ Health Perspect
, vol.118
, Issue.6
, pp. 818-824
-
-
Liu, Y.1
Wu, F.2
-
2
-
-
19944434258
-
Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance
-
Ahn SH, Park YN, Park JY, Chang HY, Lee JM, Shin JE, Han KH, Park C, Moon YM, Chon CY (2005) Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. J Hepatol 42: 188-194.
-
(2005)
J Hepatol
, vol.42
, pp. 188-194
-
-
Ahn, S.H.1
Park, Y.N.2
Park, J.Y.3
Chang, H.Y.4
Lee, J.M.5
Shin, J.E.6
Han, K.H.7
Park, C.8
Moon, Y.M.9
Chon, C.Y.10
-
3
-
-
0033559933
-
Estimates of the worldwide incidence of 25 major cancers in 1990
-
Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80: 827-841.
-
(1999)
Int J Cancer
, vol.80
, pp. 827-841
-
-
Parkin, D.M.1
Pisani, P.2
Ferlay, J.3
-
4
-
-
0032234242
-
The PreS2 activators of the hepatitis B virus: activators of tumour promoter pathways
-
Hildt E, Hofschneider PH (1998) The PreS2 activators of the hepatitis B virus: activators of tumour promoter pathways. Recent Results Cancer Res 154: 315-329.
-
(1998)
Recent Results Cancer Res
, vol.154
, pp. 315-329
-
-
Hildt, E.1
Hofschneider, P.H.2
-
5
-
-
0037084160
-
The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice
-
Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH (2002) The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. EMBO J 21(4): 525-535.
-
(2002)
EMBO J
, vol.21
, Issue.4
, pp. 525-535
-
-
Hildt, E.1
Munz, B.2
Saher, G.3
Reifenberg, K.4
Hofschneider, P.H.5
-
6
-
-
0030296929
-
The hepatitis B virus large surface protein (LHBs) is a transcriptional activator
-
Hildt E, Saher G, Bruss V, Hofschneider PH (1996) The hepatitis B virus large surface protein (LHBs) is a transcriptional activator. Virology 225(1): 235-239.
-
(1996)
Virology
, vol.225
, Issue.1
, pp. 235-239
-
-
Hildt, E.1
Saher, G.2
Bruss, V.3
Hofschneider, P.H.4
-
7
-
-
0028135497
-
Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade
-
Benn J, Schneider RJ (1994) Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 91(22): 10350-10354.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.22
, pp. 10350-10354
-
-
Benn, J.1
Schneider, R.J.2
-
8
-
-
8644274040
-
The enigmatic X gene of hepatitis B virus
-
Bouchard MJ, Schneider RJ (2004) The enigmatic X gene of hepatitis B virus. J Virol 78: 12725-12734.
-
(2004)
J Virol
, vol.78
, pp. 12725-12734
-
-
Bouchard, M.J.1
Schneider, R.J.2
-
9
-
-
0035860752
-
Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes
-
Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM (2001) Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem 276(37): 34671-34680.
-
(2001)
J Biol Chem
, vol.276
, Issue.37
, pp. 34671-34680
-
-
Tarn, C.1
Lee, S.2
Hu, Y.3
Ashendel, C.4
Andrisani, O.M.5
-
10
-
-
0001010670
-
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-l phosphorylation and associated protein kinase activity
-
Morrison DK, Kaplan DR, Rapp UR, Roberts TM (1988) Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-l phosphorylation and associated protein kinase activity. Proc Natl Acad Sci USA 85: 8855-8859.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 8855-8859
-
-
Morrison, D.K.1
Kaplan, D.R.2
Rapp, U.R.3
Roberts, T.M.4
-
12
-
-
0037810249
-
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention
-
Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, Franklin RA, McCubrey JA (2003) Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17(7): 1263-1293.
-
(2003)
Leukemia
, vol.17
, Issue.7
, pp. 1263-1293
-
-
Chang, F.1
Steelman, L.S.2
Lee, J.T.3
Shelton, J.G.4
Navolanic, P.M.5
Blalock, W.L.6
Franklin, R.A.7
McCubrey, J.A.8
-
13
-
-
0033604576
-
Isotype-specific functions of Raf kinases
-
Hagemann C, Rapp UR (1999) Isotype-specific functions of Raf kinases. Exp Cell Res 253: 34-46.
-
(1999)
Exp Cell Res
, vol.253
, pp. 34-46
-
-
Hagemann, C.1
Rapp, U.R.2
-
14
-
-
0034525423
-
Kinases: positive and negative regulators of apoptosis
-
Franklin RA, McCubrey JA (2000) Kinases: positive and negative regulators of apoptosis. Leukemia 14: 2019-2034.
-
(2000)
Leukemia
, vol.14
, pp. 2019-2034
-
-
Franklin, R.A.1
McCubrey, J.A.2
-
15
-
-
0034899450
-
Suppression of apoptosis: role in cell growth and neoplasia
-
White MK, McCubrey JA (2001) Suppression of apoptosis: role in cell growth and neoplasia. Leukemia 15: 1011-1021.
-
(2001)
Leukemia
, vol.15
, pp. 1011-1021
-
-
White, M.K.1
McCubrey, J.A.2
-
16
-
-
17344372847
-
Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
-
Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, Kasahara A, Ueki T, Hirano T, Yamamoto H, Fujimoto J, Okamoto E, Hayashi N, Hori M (1998) Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 27(4): 951-958.
-
(1998)
Hepatology
, vol.27
, Issue.4
, pp. 951-958
-
-
Ito, Y.1
Sasaki, Y.2
Horimoto, M.3
Wada, S.4
Tanaka, Y.5
Kasahara, A.6
Ueki, T.7
Hirano, T.8
Yamamoto, H.9
Fujimoto, J.10
Okamoto, E.11
Hayashi, N.12
Hori, M.13
-
17
-
-
0031561127
-
Increased MAPK expression and activity in primary human hepatocellular carcinoma
-
Schmidt CM, McKillop IH, Cahill PA, Sitzmann JV (1997) Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem Biophys Res Commun 236(1): 54-58.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, Issue.1
, pp. 54-58
-
-
Schmidt, C.M.1
McKillop, I.H.2
Cahill, P.A.3
Sitzmann, J.V.4
-
18
-
-
2442637885
-
Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma
-
Hwang YH, Choi JY, Kim S, Chung ES, Kim T, Koh SS, Lee B, Bae SH, Kim J, Park YM (2004) Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatol Res 29(2): 113-121.
-
(2004)
Hepatol Res
, vol.29
, Issue.2
, pp. 113-121
-
-
Hwang, Y.H.1
Choi, J.Y.2
Kim, S.3
Chung, E.S.4
Kim, T.5
Koh, S.S.6
Lee, B.7
Bae, S.H.8
Kim, J.9
Park, Y.M.10
-
19
-
-
69249123402
-
Expression of Raf-1 in hepatocellular carcinoma
-
Yin F, Zhao YJ, Yao SK (2009) Expression of Raf-1 in hepatocellular carcinoma. Shijie Huaren Xiaohua Zazhi 17(6): 618-622.
-
(2009)
Shijie Huaren Xiaohua Zazhi
, vol.17
, Issue.6
, pp. 618-622
-
-
Yin, F.1
Zhao, Y.J.2
Yao, S.K.3
-
20
-
-
34249945923
-
Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress
-
Chen J, Siddiqui A (2007) Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. J Virol 81(12): 6757-6760.
-
(2007)
J Virol
, vol.81
, Issue.12
, pp. 6757-6760
-
-
Chen, J.1
Siddiqui, A.2
-
21
-
-
22044452139
-
Inhibition of Hepatitis B virus gene expression by single and dual small interfering RNA treatment
-
Wu KL, Zhang X, Zhang J, Yang Y, Mu YX, Liu M, Lu L, Li Y, Zhu Y, Wu J (2005) Inhibition of Hepatitis B virus gene expression by single and dual small interfering RNA treatment. Virus Res 112(1-2): 100-107.
-
(2005)
Virus Res
, vol.112
, Issue.1-2
, pp. 100-107
-
-
Wu, K.L.1
Zhang, X.2
Zhang, J.3
Yang, Y.4
Mu, Y.X.5
Liu, M.6
Lu, L.7
Li, Y.8
Zhu, Y.9
Wu, J.10
-
22
-
-
0037025173
-
Addiction to oncogenes-the Achilles heal of cancer
-
Weinstein IB (2002) Addiction to oncogenes-the Achilles heal of cancer. Science 297(5578): 63-64.
-
(2002)
Science
, vol.297
, Issue.5578
, pp. 63-64
-
-
Weinstein, I.B.1
-
23
-
-
33749635119
-
Raf kinases: oncogenesis and drug discovery
-
Schreck R, Rapp UR (2006) Raf kinases: oncogenesis and drug discovery. Int J Cancer 119(10): 2261-2271.
-
(2006)
Int J Cancer
, vol.119
, Issue.10
, pp. 2261-2271
-
-
Schreck, R.1
Rapp, U.R.2
-
24
-
-
0345498292
-
Bcl-2 targets the protein kinase Raf-1 to mitochondria
-
Wang HG, Rapp UR, Reed JC (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87(4): 629-638.
-
(1996)
Cell
, vol.87
, Issue.4
, pp. 629-638
-
-
Wang, H.G.1
Rapp, U.R.2
Reed, J.C.3
-
25
-
-
0035377410
-
Genetic and epigenetic events in human hepatocarcinogenesis
-
Kondoh N, Wakatsuki T, Hada A, Shuda M, Tanaka K, Arai M, Yamamoto M (2001) Genetic and epigenetic events in human hepatocarcinogenesis. Int J Oncol 18(6): 1271-1278.
-
(2001)
Int J Oncol
, vol.18
, Issue.6
, pp. 1271-1278
-
-
Kondoh, N.1
Wakatsuki, T.2
Hada, A.3
Shuda, M.4
Tanaka, K.5
Arai, M.6
Yamamoto, M.7
-
26
-
-
18044387648
-
Raf kinase as a target for anticancer therapeutics
-
Sridhar SS, Hedley D, Siu LL (2005) Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 4(4): 677-685.
-
(2005)
Mol Cancer Ther
, vol.4
, Issue.4
, pp. 677-685
-
-
Sridhar, S.S.1
Hedley, D.2
Siu, L.L.3
-
27
-
-
33749836283
-
Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors
-
Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M (2006) Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. Oncogene 25(45): 6056-6066.
-
(2006)
Oncogene
, vol.25
, Issue.45
, pp. 6056-6066
-
-
Yoshida, T.1
Hisamoto, T.2
Akiba, J.3
Koga, H.4
Nakamura, K.5
Tokunaga, Y.6
Hanada, S.7
Kumemura, H.8
Maeyama, M.9
Harada, M.10
Ogata, H.11
Yano, H.12
Kojiro, M.13
Ueno, T.14
Yoshimura, A.15
Sata, M.16
-
28
-
-
0023627343
-
Transcriptional trans-activating function of hepatitis B virus
-
Twu JS, Schloemer RH (1987) Transcriptional trans-activating function of hepatitis B virus. J Virol 61(11): 3448-3453.
-
(1987)
J Virol
, vol.61
, Issue.11
, pp. 3448-3453
-
-
Twu, J.S.1
Schloemer, R.H.2
-
29
-
-
66749155533
-
Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells
-
Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM (2009) Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells. J Pharmacol Exp Ther 329(3): 1063-1070.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.3
, pp. 1063-1070
-
-
Yip-Schneider, M.T.1
Klein, P.J.2
Wentz, S.C.3
Zeni, A.4
Menze, A.5
Schmidt, C.M.6
-
30
-
-
0025299483
-
The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element
-
Unger T, Shaul Y (1990) The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element. EMBO J 9(6): 1889-1895.
-
(1990)
EMBO J
, vol.9
, Issue.6
, pp. 1889-1895
-
-
Unger, T.1
Shaul, Y.2
-
31
-
-
0025176474
-
Transactivation by the hepatitis B virus. X protein depends on AP-2 and other transcription factors
-
Seto E, Mitchell PJ, Yen TS (1989) Transactivation by the hepatitis B virus. X protein depends on AP-2 and other transcription factors. Nature 344: 72-74.
-
(1989)
Nature
, vol.344
, pp. 72-74
-
-
Seto, E.1
Mitchell, P.J.2
Yen, T.S.3
-
32
-
-
0025784335
-
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
-
Maguire HF, Hoeffler JP, Siddiqui A (1991) HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252(5007): 842-844.
-
(1991)
Science
, vol.252
, Issue.5007
, pp. 842-844
-
-
Maguire, H.F.1
Hoeffler, J.P.2
Siddiqui, A.3
-
33
-
-
0032493107
-
The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4
-
Lee YI, Lee S, Lee Y, Bong YS, Hyun SW, Yoo YD, Kim SJ, Kim YW, Poo HR (1998) The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4. Oncogene 16(18): 2367-2380.
-
(1998)
Oncogene
, vol.16
, Issue.18
, pp. 2367-2380
-
-
Lee, Y.I.1
Lee, S.2
Lee, Y.3
Bong, Y.S.4
Hyun, S.W.5
Yoo, Y.D.6
Kim, S.J.7
Kim, Y.W.8
Poo, H.R.9
|