Hepatic Akt expression correlates with advanced fibrosis in patients with chronic hepatitis C infection

Hepatology Research

Volumn 41, Issue 5, 2011, Pages 430-436

  Huang, Jee Fu ^a,b,f   Chuang, Yen Hwang ^c,g   Dai, Chia Yen ^d,f   Yu, Ming Lung ^d,e,f   Huang, Chung Feng ^f   Hsiao, Pi Jung ^h   Hsieh, Ming Yen ^f   Huang, Ching I ^f   Yeh, Ming Lun ^f   Yang, Jeng Fu ⁱ   Lin, Zu Yau ^d,f   Chen, Shinn Chern ^d,f   Chuang, Wan Long ^d,f  

^a KAOHSIUNG MUNICIPAL HSIAO KANG HOSPITAL   (Taiwan)

^b Graduate Institute of Medicine   (Taiwan)

^c Department of Otorhinolaryngology Head and Neck Surgery   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MUNICIPAL TA TUNG HOSPITAL   (Taiwan)

^f Hepatobiliary Division   (Taiwan)

^g Department of Neurology ^*  (Taiwan)

^h Endocrine Division   (Taiwan)

ⁱ KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Akt; Fibrosis; Hepatitis C virus; Immunohistochemical stain

Indexed keywords

PARAFFIN; PROTEIN KINASE B;

ADULT; ARTICLE; BIOCHEMISTRY; CHRONIC HEPATITIS; CORRELATION ANALYSIS; FATTY LIVER; FEMALE; GENOTYPE; HEPATITIS C; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK; VIROLOGY; VIRUS LOAD;

EID: 79955133702     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00786.x     Document Type: Article

References (26)

1. Yu ML, Chuang WL. Treatment of chronic hepatitis C in Asia: when East meets West. J Gastroenterol Hepatol 2009; 24: 336-45.
2. Yang JF, Lin CI, Huang JF etal. Viral hepatitis infections in southern Taiwan: a multicenter community-based study. Kaohsiung J Med Sci 2010; 26: 461-9.
3. Huang JF, Dai CY, Hwang SJ etal. Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication. Am J Gastroenterol 2007; 102: 1237-43.
4. Huang JF, Chuang WL, Dai CY etal. Viral hepatitis and proteinuria in an area endemic for hepatitis B and C infections: another chain of link? J Intern Med 2006; 260: 255-62.
5. Chuang WL, Yu ML, Dai CY, Chang WY. Treatment of chronic hepatitis C in southern Taiwan. Intervirology 2006; 49: 99-106.
6. Bowen DG, Walker CM. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005; 436: 946-52.
7. Farese RV, Sajan MP, Standaert ML. Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans 2005; 33: 350-3.
8. Noguchi M, Kinowaki K. PI3K-AKT network roles in infectious diseases. Kansenshogaku Zasshi 2008; 82: 161-7.
9. Aleffi S, Petrai I, Bertolani C etal. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 2005; 42: 1339-48.
10. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004; 126: 529-40.
11. Street A, Macdonald A, McCormick C, Harris M. Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J Virol 2005; 79: 5006-16.
12. Banerjee S, Saito K, Ait-Goughoulte M, Meyer K, Ray RB, Ray R. Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. J Virol 2008; 82: 2606-12.
13. Schmitz KJ, Wohlschlaeger J, Lang H etal. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008; 48: 83-90.
14. Okamoto H, Tokita H, Sakamoto M etal. Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J Gen Virol 1993; 74: 2385-90.
15. Knodell RG, Ishak KG, Black WC etal. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-5.
16. The French METAVIR Cooperative Study Group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994; 20: 15-20.
17. Kleiner DE, Brunt EM, Van Natta M etal. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
18. Hsu SM, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 1981; 75: 816-21.
19. Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA. Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology 2009; 50: 1512-23.
20. Lecube A, Hernandez C, Genesca J, Simo R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: a case-control study. Diabetes Care 2006; 29: 1096-101.
21. Huang JF, Chuang WL, Yu ML etal. Hepatitis C virus infection and metabolic syndrome - a community-based study in an endemic area of Taiwan. Kaohsiung J Med Sci 2009; 25: 299-305.
22. Huang JF, Yu ML, Dai CY etal. Reappraisal of the characteristics of glucose abnormalities in patients with chronic hepatitis C infection. Am J Gastroenterol 2008; 103: 1933-40.
23. Dietze D, Koenen M, Rohrig K, Horikoshi H, Hauner H, Eckel J. Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. Diabetes 2002; 51: 2369-76.
24. Aytug S, Reich D, Sapiro LE, Bernstein D, Begum N. Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology 2003; 38: 1384-92.
25. Skurk T, Alberti-Huber C, Hauner H. Effect of conditioned media from mature human adipocytes on insulin-stimulated Akt/PKB phosphorylation in human skeletal muscle cells: role of BMI and fat cell size. Horm Metab Res 2009; 41: 190-6.
26. Dai CY, Huang JF, Hsieh MY etal. Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic hepatitis C patients. J Hepatol 2009; 50: 712-18.