Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling

Experimental Hematology

Volumn 39, Issue 5, 2011, Pages 525-530

  Chen, Hongjie ^a   Koupenova, Milka ^a   Yang, Dan ^a   Sume, Siddika Selva ^b   Trackman, Philip C ^b   Ravid, Katya ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2B RECEPTOR; GELATINASE B; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMORAL ARTERY; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VASCULAR LESION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FEMALE; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ADENOSINE A2B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 79955127625     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.02.004     Document Type: Article

References (28)

1. Polosa R., Holgate S.T. Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation. Curr Drug Targets 2006, 7:699-706.
2. Hasko G., Linden J., Cronstein B., Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 2008, 7:759-770.
3. Hasko G., Csoka B., Nemeth Z.H., Vizi E.S., Pacher P. A(2B) adenosine receptors in immunity and inflammation. Trends Immunol 2009, 30:263-270.
4. Xaus J., Cardo M., Valledor A.F., Soler C., Lloberas J., Celada A. Interferon gamma induces the expression of p21waf-1 and arrests macrophage cell cycle, preventing induction of apoptosis. Immunity 1999, 11:103-113.
5. Yang D., Zhang Y., Nguyen H.G., et al. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest 2006, 116:1913-1923.
6. Yang D., Koupenova M., McCrann D.J., et al. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A 2008, 105:792-796.
7. Chen H., Yang D., Carroll S.H., Eltzschig H.K., Ravid K. Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Exp Hematol 2009, 37:533-538.
8. St Hilaire C., Koupenova M., Carroll S.H., Smith B.D., Ravid K. TNF-alpha upregulates the A2B adenosine receptor gene: the role of NAD(P)H oxidase 4. Biochem Biophys Res Commun 2008, 375:292-296.
9. St Hilaire C., Yang D., Schreiber B.M., Ravid K. B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem 2008, 103:1962-1974.
10. Wilson H.M., Barker R.N., Erwig L.P. Macrophages: promising targets for the treatment of atherosclerosis. Curr Vasc Pharmacol 2009, 7:234-243.
11. Sprague A.H., Khalil R.A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009, 78:539-552.
12. Saha P., Modarai B., Humphries J., et al. The monocyte/macrophage as a therapeutic target in atherosclerosis. Curr Opin Pharmacol 2009, 9:109-118.
13. Newby A.C., George S.J., Ismail Y., Johnson J.L., Sala-Newby G.B., Thomas A.C. Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes. Thromb Haemost 2009, 101:1006-1011.
14. Hansson G.K. Inflammatory mechanisms in atherosclerosis. J Thromb Haemost 2009, 7(suppl 1):328-331.
15. Gough P.J., Gomez I.G., Wille P.T., Raines E.W. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 2006, 116:59-69.
16. Xiong W., MacTaggart J., Knispel R., Worth J., Persidsky Y., Baxter B.T. Blocking TNF-alpha attenuates aneurysm formation in a murine model. J Immunol 2009, 183:2741-2746.
17. Shubayev V.I., Angert M., Dolkas J., Campana W.M., Palenscar K., Myers R.R. TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci 2006, 31:407-415.
18. Saren P., Welgus H.G., Kovanen P.T. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol 1996, 157:4159-4165.
19. Ernens I., Rouy D., Velot E., Devaux Y., Wagner D.R. Adenosine inhibits matrix metalloproteinase-9 secretion by neutrophils: implication of A2a receptor and cAMP/PKA/Ca2 pathway. Circ Res 2006, 99:590-597.
20. Velot E., Haas B., Leonard F., et al. Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages. Cardiovasc Res 2008, 80:246-254.
21. Zhao P., Li X.G., Yang M., et al. Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway. Mol Immunol 2008, 45:2187-2195.
22. Ryzhov S., Zaynagetdinov R., Goldstein A.E., et al. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J Pharmacol Exp Ther 2008, 324:694-700.
23. Eckle T., Krahn T., Grenz A., et al. Cardioprotection by ecto-5-nucleotidase (CD73) and A2B adenosine receptors. Circulation 2007, 115:1581-1590.
24. Krause M., Dent E.W., Bear J.E., Loureiro J.J., Gertler F.B. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol 2003, 19:541-564.
25. Genersch E., Hayess K., Neuenfeld Y., Haller H. Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J Cell Sci 2000, 113(Pt 23):4319-4330.
26. Li Y., Zhang Z., Xu Y., Xiong S., Ni W., Chen S. TNF-alpha up-regulates matrix metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci 2006, 26:647-650.
27. Moon S.K., Cha B.Y., Kim C.H. ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway. J Cell Physiol 2004, 198:417-427.
28. Zou Y., Qi Y., Roztocil E., Davies M.G. Patterns of gelatinase activation induced by injury in the murine femoral artery. J Surg Res 2009, 154:135-142.