Association of RGS2 variants with panic disorder in a Japanese population

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 4, 2011, Pages 430-434

  Otowa, Takeshi ^a,b   Shimada, Takafumi ^b   Kawamura, Yoshiya ^b   Sugaya, Nagisa ^c   Yoshida, Eiji ^d   Inoue, Ken ^e   Yasuda, Shin ^d   Liu, Xiaoxi ^f   Minato, Takanobu ^b   Tochigi, Mamoru ^b   Umekage, Tadashi ^b   Kasai, Kiyoto ^b   Tanii, Hisashi ^b   Okazaki, Yuji ^g   Kaiya, Hisanobu ^d,h   Sasaki, Tsukasa ⁱ  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d Akasaka Mental Clinic   (Japan)

^e FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f MIE UNIVERSITY   (Japan)

^g TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

^h Research Center for Panic Disorder   (Japan)

ⁱ UNIVERSITY OF TOKYO   (Japan)

Author keywords

Association; Japanese population; Panic disorder; regulator of G protein signaling 2 (RGS2); Single nucleotide polymorphism

Indexed keywords

RGS2 PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PANIC; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; JAPAN; PANIC DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; RGS PROTEINS;

EID: 79955125693     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31178     Document Type: Article

References (28)

1. Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. 2009a. Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure. J Anxiety Disord 23: 369-373.
2. Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. 2009b. Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes. Arch Suicide Res 13: 349-357.
3. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
4. Crawford DC, Nickerson DA. 2005. Definition and clinical importance of haplotypes. Annu Rev Med 56: 303-320.
5. Crowe RR, Noyes R, Pauls DL, Slymen DA. 1983. Family study of panic disorder. Arch Gen Psychiatry 40: 1065-1069.
6. Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O. 2008. Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims. Neuropsychopharmacology 33: 1537-1544.
7. Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KCC, Taylor J, Gut I, Farrall M, Lathrop GM, Abecasis GR, Cookson WOC. 2007. A whole-genome association study of global gene expression. Nat Genet 39: 1202-1207.
8. Dudbridge F. 2008. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66: 87-98.
9. Eaton WW, Kessler RC, Wittchen HU, Magee WJ. 1994. Panic and panic disorder in the United States. Am J Psychiatry 151: 413-420.
10. Flint J. 2003. Analysis of quantitative trait loci that influence animal behavior. J Neurobiol 54: 46-77.
11. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. 2002. The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
12. Ghavami A, Hunt RA, Olsen MA, Zhang J, Smith DL, Kalgaonkar S, Rahman Z, Young KH. 2004. Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity. Cell Signal 16: 711-721.
13. Goldstein RB, Wickramaratne PJ, Horwath E, Weissman MM. 1997. Familial aggregation and phenomenology of 'early'-onset (at or before age 20 years) panic disorder. Arch Gen Psychiatry 54: 271-278.
14. Hettema JM, Neale MC, Kendler KS. 2001. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158: 1568-1578.
15. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. 1992. Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Arch Gen Psychiatry 49: 716-722.
16. Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. 2009. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depress Anxiety 26: 309-315.
17. Lewontin RC. 1964. The interaction of selection and linkage I general considerations; heterotic models. Genetics 49: 49-67.
18. Leygraf A, Hohoff C, Freitag C, Willis-Owen SA, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J, Deckert J. 2006. Rgs 2 gene polymorphisms as modulators of anxiety in humans? J Neural Transm 113: 1921-1925.
19. Ohashi J, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, Tokunaga K. 2001. Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes. Ann Hum Genet 65: 197-206.
20. Oliveira-dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM. 2000. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97: 12272-12277.
21. Ross EM, Wilkie TM. 2000. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69: 795-827.
22. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. 1998. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 (Suppl 20): 22-33.
23. Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM. 2010. Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Mol Psychiatry 15: 166-176.
24. Smoller JW, Acierno JS Jr, Rosenbaum JF, Biederman J, Pollack MH, Meminger S, Pava JA, Chadwick LH, White C, Bulzacchelli M, Slaugenhaupt SA. 2001. Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. Am J Med Genet 105: 195-206.
25. Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. 2008. Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry 65: 298-308.
26. Torgersen S. 1983. Genetics of neurosis. The effects of sampling variation upon the twin concordance ratio. Br J Psychiatry 142: 126-132.
27. Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lépine JP, Newman SC, Oakley-Browne MA, Rubio-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK. 1997. The cross-national epidemiology of panic disorder. Arch Gen Psychiatry 54: 305-309.
28. Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. 2004. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36: 1197-1202.