Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats

Pharmacognosy Research

Volumn 3, Issue 1, 2011, Pages 13-18

  Lahon, Kingshuk ^a   Das, Swarnamoni ^b  

^a MAHATMA GANDHI MEDICAL COLLEGE AND RESEARCH INSTITUTE   (India)

^b ASSAM MEDICAL COLLEGE   (India)

Author keywords

Hepatoprotective; hepatotoxicity; Ocimum sanctum; paracetamol; silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; GLOBULIN; LIVER ENZYME; OCIMUM SANCTUM EXTRACT; PARACETAMOL; PLANT EXTRACT; PLASMA PROTEIN; SILYMARIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROL GROUP; CONTROLLED STUDY; DRUG POTENTIATION; FATTY LIVER; FEMALE; HISTOPATHOLOGY; LIVER CONGESTION; LIVER PROTECTION; LIVER REGENERATION; LIVER SINUSOID; LIVER TOXICITY; MALE; NONHUMAN; PLANT LEAF; RAT;

EID: 79955099811     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.79110     Document Type: Article

References (27)

1. Dossing M, Sonne J. Drug induced hepatic disorders: Incidence, management and avoidance. Drug Safety 1993;9:441-9 (Pubitemid 23358641)
2. World health organization. WHO media centre. Traditional medicine. WHO Fact sheet N°134. Available from: http://www. who.int/mediacentre/ factsheets/fs134/en/. [cited in 2008 Dec].
3. Gupta SS. Prospects and perspectives of natural plant products in medicine. Indian J Pharmacol 1994;2:1-12. (Pubitemid 24120649)
4. Satyavati GV, Gupta A, Tandon N. Medicinal plants of India (II). New Delhi: Indian Council of Medical Research; 1987.
5. Handa SS, Chakraborty KK, Sharma A. Antihepatotoxic activity of some Indian herbal formulations as compared to silymarin. Fitoterapia 1986;57:307.
6. Ram VJ. Herbal preparations as a source of hepatoprotective agents. Drug News Perspect 2001;14:353.
7. Singh S, Majumder DK. Evaluation of anti-inflammatory activity of fatty acids of Ocimum sanctum fixed oil. Indian J Exp Biol 1997;35:380-3. (Pubitemid 28103833)
8. Ali M. Indigenous traditional drugs: In Textbook of Pharmacognosy.1st ed. Delhi: CBS Publishers and Distributors; 1994. p. 312-3.
9. Bhargava KP, Singh N. Antistress activity of Ocimum sanctum Linn. Indian J Med Res 1981;73:443-51.
10. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK. Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian J Pharmacol 1992;24:163-5.
11. Ubaid RS, Anantrao KM, Jaju JB, Mateenuddin MD. Effect of Ocimum sanctum leaf extract on hepatotoxicity induced by anti-tubercular drugs in rats. Indian J Physiol Pharmacol 2003;47:465-70. (Pubitemid 37151188)
12. CPCSEA guidelines for laboratory animal facility. Committee for the purpose of control and supervision of experiments on animals. Indian J Pharmacol 2003;35:257-74.
13. Extraction and extractives. In: Remington's Pharmaceutical sciences. 14th ed. Easton Pennsylvania: Mack Publishing Company; 1965. p. 1578-93.
14. Mankani KL, Krishna V, Manjunatha BK, Vidya SM, Singh SDJ, Manohara YN, Raheman AU, Avinash KR. Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb. Indian J Pharmacol 2005 June;37(3):165-8 (Pubitemid 40898226)
15. Mansour HH, Hafez HF, Fahmy NM. Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mole Biol 2006;39:656-61. (Pubitemid 44892889)
16. Dhawan BN, Patnaik GK, Kulshereshtha DK, Sarin VK. Absence of hepatoprotective activity in Laqobo cashminana: An adulterant to Picrorhiza kurrooa. Indian J Pharma 1991;23(2):121-2.
17. Reinhold JG. Biuret method. In: Reiner M, editor. Standard Methods of Clinical Chemistry. Ann Arbor: Academic Press, Inc; vol. 1, 1953. p. 88.
18. King EJ, Abul-Fadl MAM, Walker PG. King-Armstrong phosphatase estimation by the determination of liberated phosphate. J Clin Pathol 1951;4:85.
19. Reitman S, Frankel S. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transminases. Am J Clin Pathol 1957;28:56-63.
20. Ann Preece. Manual for histologic technicians. 3rd ed. Boston: Little, Brown and Company; 1972.
21. Burke A, Smyth E, Fitzgerald GA. Analgesic-antipyretic agents: Pharmacotherapy of gout. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman's The Pharmacological basis of Therapeutics. 11th ed. USA: McGraw Hill; 2006. p. 694.
22. Poole A, Leslie GB. A practical approach to toxicological investigations. 1st ed. Cambridge: Cambridge University Press; 1989. p. 65-6.
23. Hayes AW, editor. Principles and methods of toxicology. 2nd ed. New York: Raven Press; 1989. p. 599-628.
24. Timbrell JA, editor. Principles of biochemical toxicology. 2nd ed. London: Taylor and Francis Ltd; 1982. p. 184-8.
25. Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (tulsi) with a note on eugenol and its pharmacological actions: A short review. Indian J Physiol Pharmacol 2005;49:125-31. (Pubitemid 40675735)
26. Sen P, Dewan V, Bhattacharya SK, Gupta VS, Maiti PC, Mediratta PK. In brain and Psychophyioslogy of stress. New Delhi: ICMR Publication; 1988. p. 245.
27. Singh S, Majumdar DK, Rehan HMS. Evaluation of antiinflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action. J Ethnopharmacol 1996;54:19-26. (Pubitemid 26379872)