Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model

Neurological Research

Volumn 33, Issue 3, 2011, Pages 331-336

  Jiang, Yufeng ^a,b   Lv, Hailong ^b   Huang, Shanshan ^a   Tan, Huiping ^a   Zhang, Yinong ^a   Li, He ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHIHEZI UNIVERSITY   (China)

Author keywords

Bone marrow mesenchymal stem cells; Huntington's disease; Neurotrophic factor; Quinolinic acid; Transplantation

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN DAMAGE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; HUNTINGTON CHOREA; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOTOR DYSFUNCTION; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; STEREOLOGY;

ANIMALS; BONE MARROW CELLS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUNTINGTON DISEASE; INDOLES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MOTOR ACTIVITY; NERVE GROWTH FACTORS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; ROTAROD PERFORMANCE TEST;

EID: 79955087409     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164110X12816242542571     Document Type: Article

References (24)

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993;72:971-83.
2. Hurelbrink CB, Armstrong RJ, Barker RA, Dunnett SB, Rosser AE. Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease. Cell Transplant 2000;9:743-49.
3. Chen GJ, Jeng CH, Lin SZ, Tsai SH, Wang Y, Chiang YH. Fetal striatal transplants restore electrophysiological sensitivity to dopamine in the lesioned striatum of rats with experimental Huntington's disease. J Biomed Sci 2002;9:303-10.
4. Armstrong RJ, Watts C, Svendsen CN, Dunnett SB, Rosser AE. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease. Cell Transplant 2000;9:55-64.
5. Gaura V, Bachoud-Levi AC, Ribeiro MJ, Nguyen JP, Frouin V, Baudic S, et al. Striatal neural grafting improves cortical metabolism in Huntington's disease patients. Brain 2004;127:65-72.
6. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247-56.
7. Black IB, Woodbury D. Adult rat and human bone marrow stromal stem cells differentiate into neurons. Blood Cells Mol Dis 2001;27:632-36.
8. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 2004;10 Suppl:S42-50.
9. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 2001;12:559-63.
10. Cuevas P, Carceller F, Garcia-Gomez I, Yan M, Dujovny M. Bone marrow stromal cell implantation for peripheral nerve repair. Neurol Res 2004;26:230-32.
11. Li Y, Chen J, Chen XG, Wang L, Gautam SC, Xu YX, et al. Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 2002;59:514-23.
12. Akiyama Y, Radtke C, Kocsis JD. Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J Neurosci 2002;22:6623-30.
13. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc Natl Acad Sci USA 1998;95:3908-13.
14. Emerich DF, Lindner MD, Winn SR, Chen EY, Frydel BR, Kordower JH. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J Neurosci 1996;16:5168-81.
15. Song YN, Li HZ, Zhu JN, Guo CL, Wang JJ. Histamine improves rat rota-rod and balance beam performances through H(2) receptors in the cerebellar interpositus nucleus. Neuroscience 2006;140:33-43.
16. Hamm RJ, Pike BR, O'Dell DM, Lyeth BG, Jenkins LW. The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J Neurotrauma 1994;11:187-96.
17. Rogers DC, Campbell CA, Stretton JL, Mackay KB. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 1997;28:2060-65; discussion 2066.
18. Vazey EM, Chen K, Hughes SM, Connor B. Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease. Exp Neurol 2006;199:384-96.
19. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999;96:10711-16.
20. Pittenger MF, MacKay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 2000;284:143-147.
21. Humpel C, Stromberg I, Olson L. Expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNAs in human cortical xenografts. J Neural Transplant Plast 1995;5:257-64.
22. Ourednik J, Ourednik V, Lynch WP, Schachner M, Snyder EY. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat Biotechnol 2002;20:1103-10.
23. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 2002;174:11-20.
24. Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop DJ, et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 2002;99:2199-204.