Tetrahydrobiopterin and hypertension: More than an emigrating story

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 3, 2011, Pages

  Lin, Judy Y ^a   Moens, An L ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HYDRALAZINE; HYDROCHLOROTHIAZIDE; RESERPINE; TETRAHYDROBIOPTERIN;

ANTIHYPERTENSIVE THERAPY; BIOLOGICAL ACTIVITY; BLOOD PRESSURE REGULATION; DRUG MECHANISM; EDITORIAL; ENZYME ACTIVITY; HEART MUSCLE; HUMAN; HYPERTENSION; MESENTERIC ARTERY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOPTERIN; DRUG THERAPY, COMBINATION; HUMANS; HYDRALAZINE; HYDROCHLOROTHIAZIDE; HYPERTENSION; MESENTERIC ARTERIES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RESERPINE; SIGNAL TRANSDUCTION;

EID: 79955074233     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01295.2010     Document Type: Editorial

References (5)

1. Du YH, Guan YY, Alp NJ, Channon KM, Chen AF. Endotheliumspecific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation 117: 1045-1054, 2008.
2. Kang KT, Sullivan JC, Spradley FT, d'Uscio LV, Katusic ZS, Pollock JS. Antihypertensive therapy increases tetrahydrobiopterin levels and NO/ cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. Am J Physiol Heart Circ Physiol (December 10, 2010). doi:10.1152/ajpheart.00393.2010.
3. Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest 115: 1221-1231, 2005.
4. Vidrio H, González-Romo P, Alvarez E, Alcaide C, Orallo F. Hydralazine decreases sodium nitroprusside-induced rat aortic ring relaxation and increased cGMP production by rat aortic myocytes. Life Sci 77: 3105-3116, 2005.
5. Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K, Harrison DG. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res 101: 830-838, 2007.