Skeletal muscle reflex-mediated changes in sympathetic nerve activity are abnormal in spontaneously hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 3, 2011, Pages

  Mizuno, Masaki ^a   Murphy, Megan N ^a   Mitchell, Jere H ^a   Smith, Scott A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autonomic nervous system; Blood pressure; Exercise pressor reflex; Mechanoreflex

Indexed keywords

GADOLINIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOVISUAL EQUIPMENT; BLOOD PRESSURE; CONTROLLED STUDY; DECEREBRATION; ELECTRON SPIN RESONANCE; EVOKED RESPONSE; HINDLIMB; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MECHANORECEPTOR; MUSCLE CONTRACTION; MUSCLE REFLEX; MUSCLE STRETCHING; NERVE CONDUCTION; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SKELETAL MUSCLE; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC NERVE; SYMPATHETIC TONE;

ANIMALS; BLOOD PRESSURE; GADOLINIUM; HINDLIMB; KIDNEY; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REFLEX; SYMPATHETIC NERVOUS SYSTEM;

EID: 79955068905     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01145.2010     Document Type: Article

References (55)

1. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 14: 177-183, 1989.
2. Aoki K, Sato K, Kondo S, Pyon CB, Yamamoto M. Increased response of blood pressure to rest and handgrip in subjects with essential hypertension. Jpn Circ J 47: 802-809, 1983.
3. Cheng WH, Lu PJ, Ho WY, Tung CS, Cheng PW, Hsiao M, Tseng CJ. Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure. Circ Res 106: 788-795, 2010.
4. Degtyarenko AM, Kaufman MP. Barosensory cells in the nucleus tractus solitarius receive convergent input from group III muscle afferents and central command. Neuroscience 140: 1041-1050, 2006.
5. Degtyarenko AM, Kaufman MP. MLR-induced inhibition of barosensory cells in the NTS. Am J Physiol Heart Circ Physiol 289: H2575-H2584, 2005.
6. Degtyarenko AM, Kaufman MP. Stimulation of the MLR inhibits the discharge of dorsal horn neurons responsive to muscular contraction. Brain Res 880: 178-182, 2000.
7. Delaney E, Greaney J, Edwards D, Rose W, Fadel P, Farquhar W. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol 299: H1318-H1327, 2010.
8. Esler M. The sympathetic system and hypertension. Am J Hypertens 13: 99S-105S, 2000.
9. Goodwin GM, McCloskey DI, Mitchell JH. Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension. J Physiol 226: 173-190, 1972.
10. Hamill OP, McBride DW. The pharmacology of mechanogated membrane ion channels. Pharmacol Rev 48: 231-252, 1996.
11. Hayes S, Kindig A, Kaufman M. Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents. J Appl Physiol 99: 1891-1896, 2005.
12. Hayes SG, Kaufman MP. Gadolinium attenuates exercise pressor reflex in cats. Am J Physiol Heart Circ Physiol 280: H2153-H2161, 2001.
13. Hayes SG, McCord JL, Koba S, Kaufman MP. Gadolinium inhibits group III but not group IV muscle afferent responses to dynamic exercise. J Physiol 587: 873-882, 2009.
14. Hoberg E, Schuler G, Kunze B, Obermoser AL, Hauer K, Mautner HP, Schlierf G, Kubler W. Silent myocardial ischemia as a potential link between lack of premonitoring symptoms and increased risk of cardiac arrest during physical stress. Am J Cardiol 65: 583-589, 1990.
15. Kahn JF. [The static exercise-induced arterial hypertension test]. Presse Med 20: 1067-1071, 1991.
16. Kaufman MP, Forster HV. Reflexes controlling circulatory, vetilatory and airway responses to exercise. In: Handbook of Physiology: Exercise: Regulation and Integration of Multiple Systems, edited by Rowell LB and Shepard JT. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, vol. II, chapt. 10, p. 381-447.
17. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
18. Kaufman MP, Waldrop TG, Rybicki KJ, Ordway GA, Mitchell JH. Effects of static and rhythmic twitch contractions on the discharge of group III and IV muscle afferents. Cardiovasc Res 18: 663-668, 1984.
19. Kazatani Y, Hamada M, Shigematsu Y, Hiwada K, Kokubu T. Beneficial effect of a long-term antihypertensive therapy on blood pressure response to isometric handgrip exercise in patients with essential hypertension. Am J Ther 2: 165-169, 1995.
20. Kim JK, Hayes SG, Kindig AE, Kaufman MP. Thin-fiber mechanoreceptors reflexly increase renal sympathetic nerve activity during static contraction. Am J Physiol Heart Circ Physiol 292: H866-H873, 2007.
21. Kniffki K, Mense S, Schmidt R. Responses of group IV afferent units from skeletal muscle to stretch, contraction, and chemical stimulation. Exp Brain Res 31: 511-522, 1978.
22. Koba S, Gao Z, Sinoway LI. Oxidative stress and the muscle reflex in heart failure. J Physiol 587: 5227-5237, 2009.
23. Koba S, Xing J, Sinoway LI, Li J. Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure. Am J Physiol Heart Circ Physiol 294: H311-H321, 2008.
24. Koba S, Yoshida T, Hayashi N. Renal sympathetic and circulatory responses to activation of the exercise pressor reflex in rats. Exp Physiol 91: 111-119, 2006.
25. Kohn D. Anesthesia and Analgesia in Laboratory Animals. San Diego, CA: Academic Press, 1997.
26. Kokkinos P, Andreas P, Coutoulakis E, Colleran J, Narayan P, Dotson C, Choucair W, Farmer C, Fernhall B. Determinants of exercise blood pressure response in normotensive and hypertensive women: role of cardiorespiratory fitness. J Cardipulm Rehab 22: 178-183, 2002.
27. Lanfranchi PA, Somers VK. Arterial baroreflex function and cardiovascular variability: interactions and implications. Am J Physiol Regul Integr Comp Physiol 283: R815-R826, 2002.
28. Leal AK, Williams MA, Garry MG, Mitchell JH, Smith SA. Evidence for functional alterations in the skeletal muscle mechanoreflex and metaboreflex in hypertensive rats. Am J Physiol Heart Circ Physiol 295: H1429-H1438, 2008.
29. Li J, Potts JT. NO formation in nucleus tractus solitarii attenuates pressor response evoked by skeletal muscle afferents. Am J Physiol Heart Circ Physiol 280: H2371-H2379, 2001.
30. Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 34: 724-728, 1999.
31. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
32. Matsukawa K, Wall PT, Wilson LB, Mitchell JH. Neurally mediated renal vasoconstriction during isometric muscle contraction in cats. Am J Physiol Heart Circ Physiol 262: H833-H838, 1992.
33. Matsukawa T, Mano T, Gotoh E, Ishii M. Elevated sympathetic nerve activity in patients with accelerated essential hypertension. J Clin Invest 92: 25-28, 1993.
34. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
35. Mense S, Stahnke S. Responses in muscle afferent fibers of slow conduction velocity to contractions and ischemia in the cat. J Physiol 342: 383-397, 1983.
36. Minami N, Yoshikawa T, Kataoka H, Mori N, Nagasaka M, Kurosawa H, Kanazawa M, Kohzuki M. Effects of exercise and beta-blocker on blood pressure and baroreflexes in spontaneously hypertensive rats. Am J Hypertens 16: 966-972, 2003.
37. Mitchell JH, Kaufman MP, Iwamoto GA. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol 45: 229-242, 1983.
38. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators. N Engl J Med 329: 1677-1683, 1993.
39. Mittleman MA, Siscovick DS. Physical exertion as a trigger of myocardial infarction and sudden cardiac death. Cardiol Clin 14: 263-270, 1996.
40. Moreira ED, Ida F, Oliveira VL, Krieger EM. Early depression of the baroreceptor sensitivity during onset of hypertension. Hypertension 19: II198-II201, 1992.
41. Pickering TG. Pathophysiology of exercise hypertension. Herz 12: 119-124, 1987.
42. Potts JT, Shi XR, Raven PB. Carotid baroreflex responsiveness during dynamic exercise in humans. Am J Physiol Heart Circ Physiol 265: H1928-H1938, 1993.
43. Rondon MU, Laterza MC, de Matos LD, Trombetta IC, Braga AM, Roveda F, Alves MJ, Krieger EM, Negrao CE. Abnormal muscle metaboreflex control of sympathetic activity in never-treated hypertensive subjects. Am J Hypertens 19: 951-957, 2006.
44. Sausen MT, Delaney EP, Stillabower ME, Farquhar WB. Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol 105: 351-356, 2009.
45. Seguro C, Sau F, Zedda N, Scano G, Cherchi A. [Arterial blood pressure behavior during progressive muscular exercise in subjects with stable arterial hypertension]. Cardiologia 36: 867-877, 1991.
46. Smith SA, Mitchell JH, Garry MG. Electrically induced static exercise elicits a pressor response in the decerebrate rat. J Physiol 537: 961-970, 2001.
47. Smith SA, Mitchell JH, Li J. Independent modification of baroreceptor and exercise pressor reflex function by nitric oxide in nucleus tractus solitarius. Am J Physiol Heart Circ Physiol 288: H2068-H2076, 2005.
48. Smith SA, Mitchell JH, Naseem RH, Garry MG. Mechanoreflex mediates the exaggerated exercise pressor reflex in heart failure. Circulation 112: 2293-2300, 2005.
49. Smith SA, Williams MA, Leal AK, Mitchell JH, Garry MG. Exercise pressor reflex function is altered in spontaneously hypertensive rats. J Physiol 577: 1009-1020, 2006.
50. Stebbins C, Brown B, Levin D, Longhurst J. Reflex effects of skeletal muscle mechanoreceptor stimulation of the cardiovascular system. J Appl Physiol 65: 1539-1547, 1988.
51. Tabuchi Y, Nakamaru M, Rakugi H, Nagano M, Higshimori K, Mikami H, Ogihara T. Effects of endothelin on neuroeffector junction in mesenteric arteries of hypertensive rats. Hypertension 15: 739-743, 1990.
52. Victor RG, Rotto DM, Pryor SL, Kaufman MP. Stimulation of renal sympathetic activity by static contraction: evidence for mechanoreceptorinduced reflexes from skeletal muscle. Circ Res 64: 592-599, 1989.
53. Waldrop T, Mitchell J. Effects of barodenervation on cardiovascular responses to muscle contraction. Am J Physiol Heart Circ Physiol 249: H710-H714, 1985.
54. Wallin BG, Sundlof G. A quantitative study of muscle nerve sympathetic activity in resting normotensive and hypertensive subjects. Hypertension 1: 67-77, 1979.
55. Zhao W, Swanson SA, Ye J, Li X, Shelton JM, Zhang W, Thomas GD. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 48: 637-643, 2006.