Comparison of low-dose and high-dose cosyntropin stimulation testing in children

Pediatrics International

Volumn 53, Issue 2, 2011, Pages 175-180

  Cemeroglu, Ayse Pinar ^a   Kleis, Lora ^a   Postellon, Daniel C ^a   Wood, Michael A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

cosyntropin stimulation test; high dose; hypothalamic pituitary adrenal axis; low dose

Indexed keywords

GROWTH HORMONE; HYDROCORTISONE; TETRACOSACTIDE;

ADOLESCENT; ADRENAL INSUFFICIENCY; ARTICLE; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOW DRUG DOSE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROVOCATION TEST; SCHOOL CHILD;

ADOLESCENT; ADRENAL INSUFFICIENCY; CHILD; CHILD, PRESCHOOL; COSYNTROPIN; FALSE POSITIVE REACTIONS; FEMALE; HORMONES; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOASSAY; MALE; PITUITARY-ADRENAL FUNCTION TESTS; PITUITARY-ADRENAL SYSTEM; RETROSPECTIVE STUDIES;

EID: 79955065407     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2010.03203.x     Document Type: Article

References (17)

1. Grinspoon SK, Biller BMK,. Laboratory assessment of adrenal insufficiency. J. Clin. Endocrinol. Metab. 1994; 79: 923-31. (Pubitemid 24983157)
2. Nye EJ, Grice JE, Hockings GI, et al,. Comparison of adrenocorticotropin stimulation tests and insulin hypoglycemia in normal humans: Low dose, standard high dose and 8-hour ACTH (1-24) infusion tests. J. Clin. Endocrinol. Metab. 1999; 84: 3648-55. (Pubitemid 30645220)
3. Dickstein G, Shechner C, Nicholson WE, et al,. Adrenocorticotropin stimulation test: Effects of basal cortisol level, time of the day, and suggested new sensitive low dose test. J. Clin. Endocrinol. Metab. 1991; 72: 773-8. (Pubitemid 21921764)
4. Tordjman K, Jaffe A, Grazas N, Apter C, Stern N,. The role of the low dose (1 μg) adrenocorticotropin test in the evaluation of patients with pituitary disease. J. Clin. Endocrinol. Metab. 1995; 80: 1301-5.
5. Darmon P, Dadoun F, Frachebois C, et al,. On the meaning of low-dose ACTH (1-24) tests to assess functionality of the hypothalamic-pituitary-adrenal axis. Eur. J. Endocrinol. 1999; 140: 51-5. (Pubitemid 29074768)
6. Dickstein G,. The assessment of the hypothalamo-pituitary-adrenal axis in pituitary disease: Are there short cuts? J. Endocrinol. Invest. 2003; 26: 25-30.
7. Gandhi PG, Shah NS, Khandelwal AG, Chauhan P, Menon PS,. Evaluation of low dose ACTH stimulation test in suspected secondary adrenocortical insufficiency. J. Postgrad. Med. 2002; 48: 280-2. (Pubitemid 36305510)
8. Nye EJ, Grice JE, Hockings GI, et al,. Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: Low dose, standard high dose and 8-h infusion tests. Clin. Endocrinol. (Oxf) 2001; 55: 625-33. (Pubitemid 34204445)
9. Tordjman K, Jaffe A, Trostanetsky Y, Greenman Y, Limor R, Stern N,. Low-dose (1 microgram) adrenocorticotropin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function: Sensitivity, specificity and accuracy with the high dose (250 microgram) test. Clin. Endocrinol. (Oxf) 2000; 52: 633-40. (Pubitemid 30337090)
10. Mayenknecht J, Diederich S, Bahr V, Plockinger U, Oelkers W,. Comparison of low and high dose corticotrophin stimulation tests in patients with pituitary disease. J. Clin. Endocrinol. Metab. 1998; 83: 1558-62. (Pubitemid 28501021)
11. Giordano R, Picu A, Bonelli L, et al,. Hypothalamo-pituitary-adrenal axis evaluation in patients with hypothalamo-pituitary disorders: Comparison of different provocative tests. Clin. Endocrinol. (Oxf) 2008; 68: 935-41. Epub 2007 Nov 19. (Pubitemid 351703953)
12. Alia P, Villabona C, Gimenez O, Sospedra E, Soler J, Navarro MA,. Profile, mean residence time of ACTH and cortisol responses after low and standard ACTH tests in healthy volunteers. Clin. Endocrinol. (Oxf) 2006; 65: 346-51.
13. Dickstein G, Shechner C,. Low dose ACTH test-a word of caution to the word of caution: when and how to use it. J. Clin. Endocrinol. Metab. 1997; 82: 322. (Pubitemid 27021320)
14. Dickstein G, Spigel D, Arad E, Shechner C,. Short communication. One microgram is the lowest ACTH dose to cause a maximal cortisol response. There is no diurnal variation of cortisol response to submaximal ACTH stimulation. Eur. J. Endocrinol. 1997; 137: 172-5. (Pubitemid 27342233)
15. Broide J, Soferman R, Kivity S, et al,. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J. Clin. Endocrinol. Metab. 1995; 80: 1243-6.
16. Jaruratanasirikul S, Tanchotikul S, Wongcharnchailert M, Laosombat V, Sangsupavanich P, Leetanaporn K,. A low dose adrenocorticotropin test (1 μg ACTH) for the evaluation of adrenal function in children with β-thalassemia receiving hypertransfusion with suboptimal iron-chelating therapy. J. Pediatr. Endocrinol. Metab. 2007; 20: 1183-8. (Pubitemid 350285258)
17. Maguire AM, Biesheuvel CJ, Ambler GR, Moore B, McLean M, Cowell CT,. Evaluation of adrenal function using the human corticotrophin-releasing hormone test, low dose Synacthen test and 9 am cortisol level in children and adolescents with central adrenal insufficiency. Clin. Endocrinol. (Oxf) 2008; 68: 683-91. Epub 2007 Dec 7. 18. (Pubitemid 351533436)