Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding

Biochimie

Volumn 93, Issue 6, 2011, Pages 1047-1054

  Reis, Suzana Dos ^a,g   Pang, Yanhong ^a   Vishnu, Neelanjan ^a,h   Voisset, Cécile ^b,c,d,e   Galons, Hervé ^f   Blondel, Marc ^b,c,d,e   Sanyal, Suparna ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b INSERM   (France)

^c UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^d ETABLISSEMENT FRANÇAIS DU SANG   (France)

^e CHU MORVAN   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antiprion drugs; Carbonic anhydrase; Prion; Protein folding; Ribosome

Indexed keywords

6 AMINOPHENANTHRIDINE; CARBONATE DEHYDRATASE; GUANABENZ; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG MECHANISM; ESCHERICHIA COLI; HUMAN; NONHUMAN; PROTEIN DENATURATION; PROTEIN FOLDING; RIBOSOME; SACCHAROMYCES CEREVISIAE;

CARBONIC ANHYDRASES; ESCHERICHIA COLI PROTEINS; GUANABENZ; HUMANS; PHENANTHRIDINES; PRIONS; PROTEIN FOLDING; RIBOSOMES; SACCHAROMYCES CEREVISIAE PROTEINS;

ESCHERICHIA COLI; EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 79955063817     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.03.002     Document Type: Article

References (42)

1. W. Kudlicki, A. Coffman, G. Kramer, and B. Hardesty Ribosomes and ribosomal RNA as chaperones for folding of proteins Fold Des 2 1997 101 108 (Pubitemid 127740458)
2. D. Das, A. Das, D. Samanta, J. Ghosh, S. Dasgupta, A. Bhattacharya, A. Basu, S. Sanyal, and C. Das Gupta Role of the ribosome in protein folding Biotechnol. J. 3 2008 999 1009
3. B. Das, S. Chattopadhyay, and C. Das Gupta Reactivation of denatured fungal glucose 6-phosphate dehydrogenase and E. coli alkaline phosphatase with E. coli ribosome Biochem. Biophys. Res. Commun. 183 1992 774 780
4. A.K. Bera, B. Das, S. Chattopadhyay, and C. Dasgupta Refolding of denatured restriction endonucleases with ribosomal preparations from Methanosarcina barkeri Biochem. Mol. Biol. Int. 32 1994 315 323 (Pubitemid 24082187)
5. S. Chattopadhyay, B. Das, A.K. Bera, D. Dasgupta, and C. Dasgupta Refolding of denatured lactate dehydrogenase by Escherichia coli ribosomes Biochem J. 300 Pt 3 1994 717 721 (Pubitemid 24180585)
6. S.C. Sanyal, D. Bhattacharyya, and C. Das Gupta The folding of dimeric cytoplasmic malate dehydrogenase. Equilibrium and kinetic studies Eur. J. Biochem. 269 2002 3856 3866 (Pubitemid 34989135)
7. B. Das, and C.D. Gupta Reconstitution of denatured E. coli alkaline phosphatase with E. coli ribosome Indian J. Biochem. Biophys. 29 1992 512 515
8. R.H. Argent, A.M. Parrott, P.J. Day, L.M. Roberts, P.G. Stockley, J.M. Lord, and S.E. Radford Ribosome-mediated folding of partially unfolded ricin A-chain J. Biol. Chem. 275 2000 9263 9269 (Pubitemid 30185146)
9. B. Das, S. Chattopadhyay, A.K. Bera, and C. Dasgupta In vitro protein folding by ribosomes from Escherichia coli, wheat germ and rat liver: the role of the 50S particle and its 23S rRNA Eur. J. Biochem. 235 1996 613 621
10. J. Ghosh, A. Basu, S. Pal, S. Chowdhuri, A. Bhattacharya, D. Pal, D.K. Chattoraj, and C. DasGupta Ribosome-DnaK interactions in relation to protein folding Mol. Microbiol. 48 2003 1679 1692 (Pubitemid 36751070)
11. S. Chattopadhyay, S. Pal, D. Pal, D. Sarkar, S. Chandra, and C. Das Gupta Protein folding in Escherichia coli: role of 23S ribosomal RNA Biochim. Biophys. Acta. 1429 1999 293 298 (Pubitemid 29065393)
12. S. Chattopadhyay, B. Das, and C. Dasgupta Reactivation of denatured proteins by 23S ribosomal RNA: role of domain V Proc. Natl. Acad. Sci. U S A 93 1996 8284 8287 (Pubitemid 26269549)
13. D. Pal, S. Chattopadhyay, S. Chandra, D. Sarkar, A. Chakraborty, and C. Das Gupta Reactivation of denatured proteins by domain V of bacterial 23S rRNA Nucleic Acids Res. 25 1997 5047 5051 (Pubitemid 28022268)
14. S. Pal, S. Chandra, S. Chowdhury, D. Sarkar, A.N. Ghosh, and C.D. Gupta Complementary role of two fragments of domain V of 23 S ribosomal RNA in protein folding J. Biol. Chem. 274 1999 32771 32777 (Pubitemid 129535309)
15. S.C. Sanyal, S. Pal, S. Chowdhury, and C. DasGupta 23S rRNA assisted folding of cytoplasmic malate dehydrogenase is distinctly different from its self-folding Nucleic Acids Res. 30 2002 2390 2397 (Pubitemid 34618990)
16. D. Samanta, D. Mukhopadhyay, S. Chowdhury, J. Ghosh, S. Pal, A. Basu, A. Bhattacharya, A. Das, D. Das, and C. DasGupta Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions J. Bacteriol. 190 2008 3344 3352 (Pubitemid 351581430)
17. A. Basu, D. Samanta, D. Das, S. Chowdhury, A. Bhattacharya, J. Ghosh, A. Das, and C. Dasgupta In vitro protein folding by E. coli ribosome: unfolded protein splitting 70S to interact with 50S subunit Biochem. Biophys. Res. Commun. 366 2008 598 603 (Pubitemid 50012762)
18. G. Kramer, D. Boehringer, N. Ban, and B. Bukau The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins Nat. Struct. Mol. Biol. 16 2009 589 597
19. S.B. Prusiner Novel proteinaceous infectious particles cause scrapie Science 216 1982 136 144 (Pubitemid 12089840)
20. S.B. Prusiner Prions Proc. Natl. Acad. Sci. U S A 95 1998 13363 13383 (Pubitemid 28525623)
21. C. Govaerts, H. Wille, S.B. Prusiner, and F.E. Cohen Evidence for assembly of prions with left-handed beta-helices into trimers Proc. Natl. Acad. Sci. U S A 101 2004 8342 8347 (Pubitemid 38736577)
22. A.S. Cohen Clinical aspects of amyloidosis, including related proteins and central nervous system amyloid Curr. Opin. Rheumatol. 6 1994 68 77 (Pubitemid 24148581)
23. J. Stockel, J. Safar, A.C. Wallace, F.E. Cohen, and S.B. Prusiner Prion protein selectively binds copper(II) ions Biochemistry 37 1998 7185 7193 (Pubitemid 28235199)
24. J.M. Parry, and B.S. Cox Photoreactivation of ultraviolet induced reciprocal recombination, gene conversion and mutation to prototrophy in Saccharomyces cerevisiae J. Gen. Microbiol. 40 1965 235 241
25. R.B. Wickner [URE3] as an altered URE2 p.otein: evidence for a prion analog in Saccharomyces cerevisiae Science 264 1994 566 569 (Pubitemid 24185861)
26. M. Denis-Duphil, and F. Lacroute Fine structure of the ura 2 locus in Saccharomyces cervisiae. I. In vivo complementation studies Mol. Gen. Genet. 112 1971 354 364
27. V. Coustou, C. Deleu, S. Saupe, and J. Begueret The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog Proc. Natl. Acad. Sci. U S A 94 1997 9773 9778 (Pubitemid 27408139)
28. S. Bach, N. Talarek, T. Andrieu, J.M. Vierfond, Y. Mettey, H. Galons, D. Dormont, L. Meijer, C. Cullin, and M. Blondel Isolation of drugs active against mammalian prions using a yeast-based screening assay Nat. Biotechnol. 21 2003 1075 1081 (Pubitemid 37064738)
29. S. Bach, D. Tribouillard, N. Talarek, N. Desban, F. Gug, H. Galons, and M. Blondel A yeast-based assay to isolate drugs active against mammalian prions Methods 39 2006 72 77
30. D. Tribouillard, S. Bach, F. Gug, N. Desban, V. Beringue, T. Andrieu, D. Dormont, H. Galons, H. Laude, D. Vilette, and M. Blondel Using budding yeast to screen for anti-prion drugs Biotechnol. J. 1 2006 58 67
31. D. Tribouillard-Tanvier, V. Beringue, N. Desban, F. Gug, S. Bach, C. Voisset, H. Galons, H. Laude, D. Vilette, and M. Blondel Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions PLoS One 3 2008 e1981
32. D. Tribouillard-Tanvier, S. Dos Reis, F. Gug, C. Voisset, V. Beringue, R. Sabate, E. Kikovska, N. Talarek, S. Bach, C. Huang, N. Desban, S.J. Saupe, S. Supattapone, J.Y. Thuret, S. Chedin, D. Vilette, H. Galons, S. Sanyal, and M. Blondel Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs PLoS One 3 2008 e2174
33. J.M. Armstrong, D.V. Myers, J.A. Verpoorte, and J.T. Edsall Purification and properties of human erythrocyte carbonic anhydrases J. Biol. Chem. 241 1966 5137 5149
34. M.J. Carter, and D.S. Parsons The purification and properties of carbonic anhydrases from guinea-pig erythrocytes and mucosae of the gastrointestinal tract Biochem. J. 120 1970 797 808
35. M.D. Lloyd, R.L. Pederick, R. Natesh, L.W. Woo, A. Purohit, M.J. Reed, K.R. Acharya, and B.V. Potter Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, A. novel anti-cancer agent Biochem. J. 385 2005 715 720 (Pubitemid 40208831)
36. F. Gug, S. Bach, M. Blondel, J.M. Vierfond, A.S. Martin, and H. Galons A single step synthesis of 6-aminophenanthridines from anilines and 2-chlorobenzonitriles Tetrahedron 60 2004 4705 4708 (Pubitemid 38554013)
37. F. Gug, M. Blondel, N. Desban, S. Bouaziz, J.M. Vierfond, and H. Galons An expeditious synthesis of 6-aminophenanthridines Tetrahedron Lett. 46 2005 3725 3727 (Pubitemid 40591588)
38. T.M. Schmeing, and V. Ramakrishnan What recent ribosome structures have revealed about the mechanism of translation Nature 461 2009 1234 1242
39. S. Trobro, and J. Aqvist Mechanism of peptide bond synthesis on the ribosome Proc. Natl. Acad. Sci. U S A 102 2005 12395 12400 (Pubitemid 41266370)
40. C. Huang, C.S. Mandava, and S. Sanyal The ribosomal stalk plays a key role in IF2-mediated association of the ribosomal subunits J. Mol. Biol. 399 2010 145 153
41. S. Chowdhury, S. Pal, J. Ghosh, and C. DasGupta Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro Nucleic Acids Res. 30 2002 1278 1285 (Pubitemid 34679703)
42. N. Barbezier, A. Chartier, Y. Bidet, A. Buttstedt, C. Voisset, H. Galons, M. Blondel, E. Schwarz, and M. Simonelig Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy EMBO Mol. Med. 3 2011 35 49