Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities

Archives of Pharmacal Research

Volumn 34, Issue 1, 2011, Pages 3-21

  Hayallah, Alaa M ^a   Elgaher, Walid A ^a   Salem, Ola I ^a   Abdel Alim, Abdel Alim M ^a  

^a Assiut University   (Egypt)

Author keywords

Acute toxicity; Antibacterial activity; Asthma; Bronchodilators; Xanthine derivatives

Indexed keywords

1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURINE 8 YL THIOACETOHYDRAZIDE; 6 (4 METHOXYPHENYL) 1,3 DIMETHYLTHIAZOLO[2,3 F]PURINE 2,4(1H,3H)DIONE; 8 [[(4 AMINO 5 ALKYLTHIO 4H 1,2,4 TRIAZOL 3 YL)METHYL]THIO] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE DERIVATIVE; 8 [[(4 AMINO 5 THIOXO 4,5 DIHYDRO 1H 1,2,4 TRIAZOL 3 YL)METHYL]THIO] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 [[[4 [(4 UNSUBSTITUTED BENZYLIDENE)AMINO] 5 UNSUBSTITUTED THIO 1,2,4 TRIAZOL 3 YL]METHYL]THIO]THEOPHYLLINE DERIVATIVE; ACETYLCHOLINE; AMIDE; AMINOPHYLLINE; ANTIBIOTIC AGENT; BRONCHODILATING AGENT; METHYL [(1,3 DIMETHYL 2,6 DIOXO 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL)THIO]ACETATE; THEOPHYLLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BRONCHODILATATION; BRONCHOSPASM; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ACUTE TOXICITY TESTS; AMINOPHYLLINE; AMPICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; ASTHMA; BRONCHIAL SPASM; BRONCHODILATOR AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GUINEA PIGS; MALE; MICE; THEOPHYLLINE;

EID: 79955055594     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0101-8     Document Type: Article

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