Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 15-16, 2011, Pages 1049-1055

  Philipp, Anika A ^a   Wissenbach, Dirk K ^a   Weber, Armin A ^a   Zapp, Josef ^b   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Isopaynantheine; Kratom; LC MSn; Metabolism; Mitraciliatine; Urine

Indexed keywords

ISOPAYNANTHEINE; KRATOM; LC-MSN; MITRACILIATINE; URINE;

BIOMOLECULES; BODY FLUIDS; ELECTRON TRAPS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; NITROGEN COMPOUNDS; PHYSIOLOGY; RATS;

METABOLITES;

ALKALOID DERIVATIVE; ISOPAYNANTHEINE; MITRACILIATINE; MITRAGYNINE; PAYNANTHEINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DIASTEREOISOMER; HERBAL MEDICINE; HUMAN; ION TRAP MASS SPECTROMETRY; ISOMERISM; LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITE; MITRAGYNA; NONHUMAN; PRIORITY JOURNAL; RAT; URINALYSIS;

ANIMALS; CHROMATOGRAPHY, LIQUID; HUMANS; INDOLE ALKALOIDS; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; MITRAGYNA; PLANT LEAVES; RATS; RATS, WISTAR; SECOLOGANIN TRYPTAMINE ALKALOIDS; STEREOISOMERISM;

MITRAGYNA SPECIOSA; RATTUS;

EID: 79955049824     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.03.005     Document Type: Article

References (14)

1. Ponglux D., Wongseripipatana S., Takayama H., Kikuchi M., Kurihara M., Kitajima M., Aimi N., Sakai S. Planta Med. 1994, 60:580.
2. Shellard E.J. Bull. Narc. 1974, 26:41.
3. Kitajima M., Misawa K., Kogure N., Said I.M., Horie S., Hatori Y., Murayama T., Takayama H. J. Nat. Med. 2006, 60:28.
4. Shellard E.J., Houghton P.J., Resha M. Planta Med. 1978, 34:253.
5. Takayama H. Chem. Pharm. Bull. (Tokyo) 2004, 52:916.
6. Arndt T., Claussen U., Gussregen B., Schrofel S., Sturzer B., Werle A., Wolf G. Forensic Sci. Int. 2011, Epubahead of print. 10.1016/j.forsciint.2010.10.025.
7. Matsumoto K., Horie S., Ishikawa H., Takayama H., Aimi N., Ponglux D., Watanabe K. Life Sci. 2004, 74:2143.
8. Philipp A.A., Wissenbach D.K., Weber A.A., Zapp J., Maurer H.H. J. Mass Spectrom. 2010, 45:1344.
9. Philipp A.A., Wissenbach D.K., Zoerntlein S.W., Klein O.N., Kanogsunthornrat J., Maurer H.H. J. Mass Spectrom. 2009, 44:1249.
10. Philipp A.A., Wissenbach D.K., Weber A.A., Zapp J., Zoerntlein S.W., Klein O.N., Kanogsunthornrat J., Maurer H.H. Anal. Bioanal. Chem. 2010, 396:2379.
11. Philipp A.A., Wissenbach D.K., Weber A.A., Zapp J., Maurer H.H. Anal. Bioanal. Chem. 2011, 399:2747.
12. Lu S., Tran B.N., Nelsen J.L., Aldous K.M. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:2499.
13. Staerk D., Norrby P.O., Jaroszewski J.W. J. Org. Chem. 2001, 66:2217.
14. Hasegawa J., Smith P.C., Benet L.Z. Drug Metab. Dispos. 1982, 10:469.