Reduced number of actinic keratoses with topical application of DNA repair enzyme creams

Journal of Drugs in Dermatology

Volumn 9, Issue 12, 2010, Pages 1519-1521

  DeBoyes, Telia ^a   Kouba, David ^b   Ozog, David ^c   Fincher, Edgar ^c   Moy, Lauren ^d   Iwata, Kathryn ^c   Moy, Ronald ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c Moy Fincher Medical Group   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA REPAIR FORMULA; UNCLASSIFIED DRUG; ENDONUCLEASE V, PHAGE T4; LIPOSOME; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; VIRUS PROTEIN;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; ENZYME THERAPY; HUMAN; LOTION; PATIENT ASSESSMENT; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; HOSPITALIZATION; MIDDLE AGED; PATHOLOGY; SUNLIGHT; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, TOPICAL; AGED; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA REPAIR ENZYMES; HUMANS; KERATOSIS, ACTINIC; LIPOSOMES; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SUNLIGHT; ULTRAVIOLET RAYS; VIRAL PROTEINS;

EID: 79955045036     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Stockfleth E, Kerl H. Guidelines for the management of actinic keratoses. Euro J Dermatol. 2006;16(6):599-606.
2. Jancin B. Study hikes risk of cancer from AKs. Skin Allergy News. 2008;39:1.
3. Criscione VD, Weinstock MA, Naylor MF, et al. Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group. Cancer. 2009;115(11):2523-2530.
4. Kaufmann R, Spelman L, Weightman W, et al. Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities. Br J Dermatol. 2008;158(5):994-999. (Pubitemid 351521450)
5. Yarosh D, Klein J, O'Connor A, et al. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: A randomized study. Xeroderma Pigmentosum Study Group. Lancet. 2001;357:926-929. (Pubitemid 32247282)
6. Yarosh D, Alas LG, Yee V, et al. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res. 1992;52(15):4227-4223.
7. Yarosh DB, Kibitel JT, Green LA, Spinowitz A. Enhanced unscheduled DNA synthesis in UV-irradiated human skin explants treated with T4N5 liposomes. J Invest Dermatol. 1991;97(1):147-150.
8. Gilchrest BA, Zhai S, Eller MS, et al. Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation. J Invest Dermatol. 1993;101(5):666-672. (Pubitemid 23322021)
9. Wolf P, Maier H, Mullegger RR, et al. Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha. J Invest Dermatol. 2000;114(1):149-156. (Pubitemid 30195988)
10. st ed. New York, NY: Broadway Books. 2008.
11. Goukassian D, Gad F, Yaar M, et al. Mechanisms and implications of the age-associated decrease in DNA repair capacity. The FASEB Journal. 2000;14:1325-1334. (Pubitemid 30439741)