Reaction of ethyl 5-acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3- N, N-bis-nucleophiles: A facile access to novel pyrimidine derivatives

Synthesis

Volumn , Issue 9, 2011, Pages 1465-1471

  Maximov, Nazar B ^a,b   Mykhailiuk, Pavel K ^a,b   Kisel, Andrei I ^b   Voitenko, Zoia V ^b   Tolmachev, Andrey A ^a,b  

^a ENAMINE LTD   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

amidines; amino heterocycles; pyrimidines; tetrahydropyridine

Indexed keywords

AMIDINES; DIHYDROPYRIDINES; FACILE ACCESS; GOOD YIELD; HETEROCYCLES; PYRIMIDINE DERIVATIVES; PYRIMIDINES; REGIO-SELECTIVE; TETRAHYDROPYRIDINE;

CARBOXYLATION; NUCLEOPHILES; PYRIDINE;

AROMATIC COMPOUNDS;

1,3 N,N BIS NUCLEOPHILE; 3 (2 METHYLPYRIDO [2',3':3,4]PYRAZOLO [1,5 A]PYRIMIDIN 3 YL)PROPAN 1 AMINE; 3 (2 METHYLPYRIMIDO [1,2 A]BENZIMIDAZOL 3 YL)PROPAN 1 AMINE; 3 (2 METHYLPYRIMIDO [1,2 B]INDAZOL 3 YL)PROPAN 1 AMINE; 3 (2 METHYLPYRIMIDO [2,1 A]ISOINDOL 3 YL)PROPAN 1 AMINE; 3 (2,5 DIMETHYLPYRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPAN 1 AMINE; 3 (5 METHYLPYRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPAN 1 AMINE; 3 (5 METHYLTETRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPAN 1 AMINE; 3 (7 METHYL [1,2,4] TRIAZOLO [4,3 A]PYRIMIDIN 6 YL)PROPAN 1 AMINE; 3 (7 METHYLIMIDAZO [1,2 A]PYRIMIDIN 6 YL)PROPAN 1 AMINE; 6 (3 AMINOPROPYL) 5 METHYLPYRAZOLO [1,5 A]PYRIMIDINE 3 CARBOXYLIC ACID; 6 (3 AMINOPROPYL) 7 METHYLIMIDAZO [1,2 A]PYRIMIDINE 2 CARBOXYLIC ACID; ETHYL 3 (2 AMINO 4 METHYLPYRIMIDIN 5 YL)PROPYLCARBAMATE; ETHYL 3 (2 METHYLPYRIMIDO [1,2 A]BENZIMIDAZOL 3 YL)PROPYLCARBAMATE; ETHYL 3 (2 METHYLPYRIMIDO [1,2 B]INDAZOL 3 YL)PROPYLCARBAMATE; ETHYL 3 (2 METHYLPYRIMIDO [2',3':3,4]PYRAZOLOL [1,5 A]PYRIMIDIN 3 YL)PROPYLCARBAMATE; ETHYL 3 (2,5 DIMETHYLPYRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 (2METHYLPYRIMIDO [2,1 A]ISOINDOL 3 YL)PROPYLCARBAMATE; ETHYL 3 (3 CYANO 5 METHYLPYRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 (4 METHYL 2 PHENYLPYRIMIDIN 5 YL)PROPYLCARBAMATE; ETHYL 3 (5 METHYLPYRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 (5METHYLTETRAZOLO [1,5 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 (7 METHYL [1,2,4] TRIAZOLO [4,3 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 (7 METHYLIMIDAZO [1,2 A]PYRIMIDIN 6 YL)PROPYLCARBAMATE; ETHYL 3 [2 (AMINOCARBONYL) 7 METHYLIMIDAZO [1,2 A]PYRIMIDIN 6 YL]PROPYLCARBAMATE; ETHYL 5 [1 (1H PYRAZOL 5 YLIMINO)ETHYL] 3,4 DIHYDROPYRIDINE 1 (2H)CARBOXYLATE; ETHYL 5 ACETYL 3,4 DIHYDROPYRIDINE 1 (2H) CARBOXYLATE; NUCLEOPHILE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; NUCLEAR OVERHAUSER EFFECT; SYNTHESIS;

EID: 79955030781     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1259970     Document Type: Article

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