Novel cytochrome P450-mediated ring opening of the 1,3,4-oxadiazole in setileuton, a 5-lipoxygenase inhibitor

Drug Metabolism and Disposition

Volumn 39, Issue 5, 2011, Pages 763-770

  Maciolek, Cheri M ^a   Ma, Bennett ^a   Menzel, Karsten ^a   Laliberte, Sebastien ^b   Bateman, Kevin ^b   Krolikowski, Paul ^c   Gibson, Christoper R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A2; DRUG METABOLITE; OXADIAZOLE; OXADIAZOLE DERIVATIVE; OXYGEN 18; SETILEUTON; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; INSECT CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RING OPENING;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ASTHMA; ATHEROSCLEROSIS; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; LIPOXYGENASE INHIBITORS; MALE; MICROSOMES, LIVER; OXADIAZOLES; RATS;

CANIS FAMILIARIS; RATTUS;

EID: 79955026356     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.037366     Document Type: Article

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