Rapid and transient activation of γδ T cells to IFN-γ production, NK cell-like killing, and antigen processing during acute virus infection

Journal of Immunology

Volumn 186, Issue 8, 2011, Pages 4853-4861

  Toka, Felix N ^a,b   Kenney, Mary A ^a   Golde, William T ^a  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^b WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSOMAL AMINOPEPTIDASE; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; PERFORIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; GAMMA DELTA T LYMPHOCYTE; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET CELL;

ACUTE DISEASE; ANIMALS; ANTIGEN PRESENTATION; CATTLE; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; K562 CELLS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MEMBRANE GLYCOPROTEINS; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TIME FACTORS;

EID: 79955023106     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003599     Document Type: Article

References (47)

1. Gibbons, D. L., S. F. Haque, T. Silberzahn, K. Hamilton, C. Langford, P. Ellis, R. Carr, and A. C. Hayday. 2009. Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants. Eur. J. Immunol. 39:1794-1806.
2. Tuo, W., F. W. Bazer, W. C. Davis, D. Zhu, and W. C. Brown. 1999. Differential effects of type I IFNs on the growth of WC1-CD8+ gamma delta T cells and WC1+ CD8-gamma delta T cells in vitro. J. Immunol. 162:245-253. (Pubitemid 29018926)
3. Hayday, A. C. 2009. Gammadelta T cells and the lymphoid stress-surveillance response. Immunity 31:184-196.
4. Wijngaard, P. L., M. J. Metzelaar, N. D. MacHugh, W. I. Morrison, and H. C. Clevers. 1992. Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8-gamma delta T lymphocytes. J. Immunol. 149:3273-3277.
5. Aruffo, A., M. A. Bowen, D. D. Patel, B. F. Haynes, G. C. Starling, J. A. Gebe, and J. Bajorath. 1997. CD6-ligand interactions: a paradigm for SRCR domain function? Immunol. Today 18:498-504. (Pubitemid 27441594)
6. Rogers, A. N., D. G. Van Buren, E. Hedblom, M. E. Tilahun, J. C. Telfer, and C. L. Baldwin. 2005. Function of ruminant gammadelta T cells is defined by WC1.1 or WC1.2 isoform expression. Vet. Immunol. Immunopathol. 108:211-217. (Pubitemid 41317083)
7. Rogers, A. N., D. G. Vanburen, E. E. Hedblom, M. E. Tilahun, J. C. Telfer, and C. L. Baldwin. 2005. Gammadelta T cell function varies with the expressed WC1 coreceptor. J. Immunol. 174:3386-3393. (Pubitemid 40354043)
8. Vesosky, B., O. C. Turner, J. Turner, and I. M. Orme. 2003. Activation marker expression on bovine peripheral blood gammadelta T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine. Dev. Comp. Immunol. 27:439-447. (Pubitemid 36288456)
9. Yasuda, M., D. Ogawa, T. Nasu, T. Yamaguchi, and T. Murakami. 2005. Kinetics and distribution of bovine gammadelta T-lymphocyte in the intestine: gammadelta T cells accumulate in the dome region of Peyer's patch during prenatal development. Dev. Comp. Immunol. 29:555-564. (Pubitemid 40326991)
10. Sathiyaseelan, T., A. Rogers, and C. L. Baldwin. 2002. Response of bovine gammadelta T cells to activation through CD3. Vet. Immunol. Immunopathol. 90:155-168. (Pubitemid 35375920)
11. Bukowski, J. F., C. T. Morita, and M. B. Brenner. 1994. Recognition and destruction of virus-infected cells by human gamma delta CTL. J. Immunol. 153:5133-5140. (Pubitemid 24356144)
12. Amadori, M., I. L. Archetti, R. Verardi, and C. Berneri. 1995. Role of a distinct population of bovine gamma delta T cells in the immune response to viral agents. Viral Immunol. 8:81-91. (Pubitemid 26025308)
13. Silflow, R. M., P. M. Degel, and A. G. Harmsen. 2005. Bronchoalveolar immune defense in cattle exposed to primary and secondary challenge with bovine viral diarrhea virus. Vet. Immunol. Immunopathol. 103:129-139. (Pubitemid 40038228)
14. Sciammas, R., P. Kodukula, Q. Tang, R. L. Hendricks, and J. A. Bluestone. 1997. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J. Exp. Med. 185:1969-1975. (Pubitemid 27247083)
15. Hoek, A., V. P. Rutten, J. Kool, G. J. Arkesteijn, R. J. Bouwstra, I. Van Rhijn, and A. P. Koets. 2009. Subpopulations of bovine WC1 (+) gammadelta T cells rather than CD4 (+) CD25 (high) Foxp3 (+) T cells act as immune regulatory cells ex vivo. Vet. Res. 40:6.
16. Toka, F. N., C. K. Nfon, H. Dawson, and W. T. Golde. 2009. Accessory-cellmediated activation of porcine NK cells by Toll-like receptor 7 (TLR7) and TLR8 agonists. Clin. Vaccine Immunol. 16:866-878.
17. Endsley, J. J., M. A. Endsley, and D. M. Estes. 2006. Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages. J. Leukoc. Biol. 79:71-79. (Pubitemid 43054251)
18. Bautista, E. M., G. S. Ferman, and W. T. Golde. 2003. Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV). Vet. Immunol. Immunopathol. 92:61-73. (Pubitemid 36298683)
19. Baldwin, C. L., T. Sathiyaseelan, B. Naiman, A. M. White, R. Brown, S. Blumerman, A. Rogers, and S. J. Black. 2002. Activation of bovine peripheral blood gammadelta T cells for cell division and IFN-gamma production. Vet. Immunol. Immunopathol. 87:251-259. (Pubitemid 34665246)
20. Bembridge, G. P., N. D. MacHugh, D. McKeever, E. Awino, P. Sopp, R. A. Collins, K. I. Gelder, and C. J. Howard. 1995. CD45RO expression on bovine T cells: relation to biological function. Immunology 86:537-544. (Pubitemid 26050261)
21. Bastos, R. G., W. C. Johnson, W. C. Brown, and W. L. Goff. 2007. Differential response of splenic monocytes and DC from cattle to microbial stimulation with Mycobacterium bovis BCG and Babesia bovis merozoites. Vet. Immunol. Immunopathol. 115:334-345. (Pubitemid 46127709)
22. Brandes, M., K. Willimann, and B. Moser. 2005. Professional antigenpresentation function by human gammadelta T cells. Science 309:264-268. (Pubitemid 40967855)
23. Cheng, L., Y. Cui, H. Shao, G. Han, L. Zhu, Y. Huang, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun. 2008. Mouse gammadelta T cells are capable of expressing MHC class II molecules, and of functioning as antigenpresenting cells. J. Neuroimmunol. 203:3-11.
24. Wu, Y., W. Wu, W. M. Wong, E. Ward, A. J. Thrasher, D. Goldblatt, M. Osman, P. Digard, D. H. Canaday, and K. Gustafsson. 2009. Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J. Immunol. 183:5622-5629.
25. Díaz-San Segundo, F., F. J. Salguero, A. de Avila, M. M. de Marco, M. A. Sánchez-Martín, and N. Sevilla. 2006. Selective lymphocyte depletion during the early stage of the immune response to foot-and-mouth disease virus infection in swine. J. Virol. 80:2369-2379. (Pubitemid 43271542)
26. Dusinský, R., M. Bardotti, and W. Ponti. 2000. Decreased expression of L-selectin (CD62L) on lymphocytes in enzootic bovine leukaemia. J. Vet. Med. B Infect. Dis. Vet. Public Health 47:127-132. (Pubitemid 30174378)
27. Waters, W. R., T. E. Rahner, M. V. Palmer, D. Cheng, B. J. Nonnecke, and D. L. Whipple. 2003. Expression of L-selectin (CD62L), CD44, and CD25 on activated bovine T cells. Infect. Immun. 71:317-326. (Pubitemid 36026035)
28. Walcheck, B., and M. A. Jutila. 1994. Bovine gamma delta T cells express high levels of functional peripheral lymph node homing receptor (L-selectin). Int. Immunol. 6:81-91.
29. Daubenberger, C. A., E. L. Taracha, L. Gaidulis, W. C. Davis, and D. J. McKeever. 1999. Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva. Infect. Immun. 67:2241-2249. (Pubitemid 29200478)
30. Storset, A. K., S. Kulberg, I. Berg, P. Boysen, J. C. Hope, and E. Dissen. 2004. NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. Eur. J. Immunol. 34:669-676. (Pubitemid 39255914)
31. Boysen, P., I. Olsen, I. Berg, S. Kulberg, G. M. Johansen, and A. K. Storset. 2006. Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status. BMC Immunol. 7:10.
32. Wilson, E., M. K. Aydintug, and M. A. Jutila. 1999. A circulating bovine gamma delta T cell subset, which is found in large numbers in the spleen, accumulates inefficiently in an artificial site of inflammation: correlation with lack of expression of E-selectin ligands and L-selectin. J. Immunol. 162:4914-4919. (Pubitemid 29314897)
33. Brown, W. C., W. C. Davis, S. H. Choi, D. A. E. Dobbelaere, and G. A. Splitter. 1994. Functional and phenotypic characterization of WC1+ gamma/delta T cells isolated from Babesia bovis-stimulated T cell lines. Cell. Immunol. 153:9-27. (Pubitemid 24071579)
34. Alvarez, A. J., J. J. Endsley, D. Werling, and D. Mark Estes. 2009. WC1 (+) gammadelta T cells indirectly regulate chemokine production during Mycobacterium bovis infection in SCID-bo mice. Transbound Emerg. Dis. 56:275-284.
35. Nelson, D. D., W. C. Davis, W. C. Brown, H. Li, D. O'Toole, and J. L. Oaks. 2010. CD8 (+)/perforin (+)/WC1 (-) gammadelta T cells, not CD8 (+) alphabeta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Vet. Immunol. Immunopathol. 136:284-291.
36. Li, B. X., J. W. Ge, and Y. J. Li. 2007. Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus. Virology 365:166-172. (Pubitemid 46907229)
37. Nam, E., and C. Lee. 2010. Contribution of the porcine aminopeptidase N (CD13) receptor density to porcine epidemic diarrhea virus infection. Vet. Microbiol. 144:41-50.
38. Oh, J. S., D. S. Song, J. S. Yang, J. Y. Song, H. S. Yoo, Y. S. Jang, and B. K. Park. 2004. Effect of soluble porcine aminopeptidase N on antibody production against porcine epidemic diarrhea virus. J. Vet. Sci. 5:353-357.
39. Van Rhijn, I., V. P. M. G. Rutten, B. Charleston, M. Smits, W. van Eden, and A. P. Koets. 2007. Massive, sustained gammadelta T cell migration from the bovine skin in vivo. J. Leukoc. Biol. 81:968-973. (Pubitemid 46495645)
40. Howard, C. J., P. Sopp, J. Brownlie, K. R. Parsons, L. S. Kwong, and R. A. Collins. 1996. Afferent lymph veiled cells stimulate proliferative responses in allogeneic CD4+ and CD8+ T cells but not gamma delta TCR+ T cells. Immunology 88:558-564. (Pubitemid 26255125)
41. Juleff, N., M. Windsor, E. A. Lefevre, S. Gubbins, P. Hamblin, E. Reid, K. McLaughlin, P. C. L. Beverley, I. W. Morrison, and B. Charleston. 2009. Foot-and-mouth disease virus can induce a specific and rapid CD4+ T-cellindependent neutralizing and isotype class-switched antibody response in naive cattle. J. Virol. 83:3626-3636.
42. O'Brien, R. L., M. P. Happ, A. Dallas, E. Palmer, R. Kubo, and W. K. Born. 1989. Stimulation of a major subset of lymphocytes expressing T cell receptor gamma delta by an antigen derived from Mycobacterium tuberculosis. Cell 57:667-674. (Pubitemid 19140647)
43. Blumerman, S. L., C. T. Herzig, and C. L. Baldwin. 2007. WC1+ gammadelta T cell memory population is induced by killed bacterial vaccine. Eur. J. Immunol. 37:1204-1216. (Pubitemid 46925305)
44. Nfon, C. K., G. S. Ferman, F. N. Toka, D. A. Gregg, and W. T. Golde. 2008. Interferon-alpha production by swine dendritic cells is inhibited during acute infection with foot-and-mouth disease virus. Viral Immunol. 21:68-77. (Pubitemid 351450458)
45. Nfon, C. K., F. N. Toka, M. Kenney, J. M. Pacheco, and W. T. Golde. 2010. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection. Viral Immunol. 23:29-41.
46. Golde, W. T., J. M. Pacheco, H. Duque, T. Doel, B. Penfold, G. S. Ferman, D. R. Gregg, and L. L. Rodriguez. 2005. Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: use in emergency outbreak response. Vaccine 23:5775-5782. (Pubitemid 41668884)
47. Pacheco, J. M., J. E. Butler, J. Jew, G. S. Ferman, J. Zhu, and W. T. Golde. 2010. IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination. Clin. Vaccine Immunol. 17:550-558.