Loss of phenotypic expression is related to tumour progression in early gastric differentiated adenocarcinoma

Histopathology

Volumn 47, Issue 4, 2005, Pages 357-367

  Nakamura, T ^a   Yao, Takashi ^a,b   Kabashima, A ^a   Nishiyama, K ^a   Maehara, Y ^a   Tsuneyoshi, Masazumi ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

CD10; Early differentiated gastric carcinoma; Human gastric mucin; MUC2; Phenotype

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; MUCIN 2; STOMACH MUCIN;

ARTICLE; CANCER INVASION; GOBLET CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE BRUSH BORDER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PYLORUS; SMALL INTESTINE; STOMACH ADENOCARCINOMA; STOMACH MUCOSA; TUMOR GROWTH;

ADENOCARCINOMA; AGED; DISEASE PROGRESSION; FEMALE; GASTRIC MUCIN; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MUCINS; NEPRILYSIN; PHENOTYPE; STOMACH NEOPLASMS;

EID: 26444567734     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2005.02242.x     Document Type: Article

References (35)

1. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta. Pathol. Microbiol. Immunol. Scand. 1965; 64; 31-49.
2. Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. GANN 1968; 59; 251-258.
3. Tatematsu M, Ichinose M, Miki K, Hasegawa R, Kato T, Ito N. Gastric intestinal phenotype expression of human stomach cancers as revealed by peptinogen immunohistochemistry and mucin histochemistry. Acta Pathol. Jap. 1990; 40; 494-504.
4. Egashira Y. Mucin histochemical study of differentiated adenocarcinoma of stomach. Jpn J. Gastroenterol. 1994; 91; 839-848.
5. Kabashima A, Yao T, Sugimachi K, Tsuneyoshi M. Gastric or intestinal phenotypic expression in the carcinomas and background mucosa of multiple early gastric carcinomas. Histopathology 2000; 37; 513-522.
6. Jass JR. Mucin core proteins as differentiation markers in the gastrointestinal tract. Histopathology 2000; 37; 561-564.
7. Yao T, Kabashima A, Tsuneyoshi M. The phenotypes of the gastric carcinoma-evaluation by a new immunohistochemical method. Stomach Intestine (I Chou) 1999; 34; 477-485.
8. Machado JC, Nogueira AMMF, Carneiro F, Reis CA, Sobrinho-Simoes M. Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6). J. Pathol. 2000; 190; 437-443.
9. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 2000; 89; 724-732.
10. Oya M, Yao T, Tsuneyoshi M. A correlation of intramural tumor invasion with mucin histochemistry, and immunohistochemical expressions of oncogene-related proteins in early gastric carcinomas. Stomach Intestine (I Chou) 1997; 32; 31-39.
11. Ito E, Takizawa T. Differentiated adenocarcinoma of the gastric and intestinal phenotype-histological appearance and biological behavior. Stomach Intestine (I Chou) 2003; 38; 701-706.
12. Saito A, Shimoda T, Nakanishi Y, Ochiai A, Toda G. Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol. Int. 2001; 51; 165-171.
13. Kubo K, Yanagisawa A, Ninomiya Y, Inoshita N, Kato Y. Characteristics of differentiated-type carcinoma with gastric phenotype of the stomach. Stomach Intestine (I Chou) 1999; 34; 487-494.
14. Nishikura K, Watanabe H, Ajioka Y et al. Differentiated adenocarcinoma with gastric phenotype - its new classification and histopathological characteristics. Stomach Intestine (I Chou) 1999; 34; 495-506.
15. Koseki K, Takizawa T, Koike M, Funata N, Hishima T. Subclassification of well differentiated gastric cancer with reference to biological behavior and malignancy, gastric type vs. intestinal type, and papillary carcinoma vs. tubular carcinoma. Stomach Intestine (I Chou) 1999; 34; 507-512.
16. Kabashima A, Yao T, Sugimachi K, Tsuneyoshi M. Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinoma. Hum. Pathol. 2002; 33; 80-86.
17. Endoh Y, Tamura G, Watanabe H, Ajioka Y, Motoyama T. The common 18 base pair deletion at codons 418-423 of the cadherin gene in differentiated-type adenocarcinomas and intramucosal precancerous lesions of the stomach with the features of gastric foveolar epithelium. J. Pathol. 1999; 189; 201-206.
18. Endoh Y, Tamura G, Ajioka Y, Watanabe H, Motoyama T. Frequent hypermethylation of the hMLH1 gene promoter in differentiated type tumors of the stomach with the gastric foveolar phenotype. Am. J. Pathol. 2000; 157; 717-722.
19. Endoh Y, Sakata K, Tamura G et al. Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways. J. Pathol. 2000; 191; 257-263.
20. Ohmura K, Tamura G, Endoh Y, Sakata K, Takahashi T, Motoyama T. Microsatellite alterations in differentiated-type adenocarcinoma and precancerous lesions of the stomach with special reference to cellular phenotype. Hum. Pathol. 2000; 31; 1031-1035.
21. Kushima R, Mukaisho K, Tsukashita S et al. Molecular biological characteristics of early stomach adenocarcinomas of the completely gastric phenotype revealed by laser capture microdissection and comparative genomic hybridization. Stomach Intestine (I Chou) 2003; 38; 707-721.
22. Yoshino T, Shimoda T, Saitoh A et al. Macroscopic features of differentiated adenocarcinoma with gastric or intestinal phenotype expression in early gastric cancer. Stomach Intestine (I Chou) 1999; 34; 513-525.
23. Oda I, Gotoda T, Hasuike N, Hamanaka H, Eguchi T. Endoscopic features of differentiated-type early gastric carcinoma with gastric mucin phenotype. Stomach Intestine (I Chou) 2003; 38; 684-691.
24. Ikeda Y, Mori M, Kamakura T, Haraguchi Y, Saku M, Sugimachi K. Increased incidence of undifferentiated type of gastric cancer with tumor progression in 912 patients with early gastric cancer and 1245 with advanced gastric cancer. Cancer 1994; 73; 2459-2463.
25. Shimoda T, Fujisaki J, Kashimura H. Histological type of gastric carcinoma in relation to the mode of intramural spreading of cancer cells. Stomach Intestine (I Chou) 1991; 26; 1125-1134.
26. Fujisaki J, Ikegami M, Arai Y, Ichinose M, Masui Y, Suzuki H. Endoscopic mucosal resection of early gastric carcinoma-the possibility of extending vertical invasion. The criterion for determining endoscopic therapeutical limit. Stomach Intestine (I Chou) 1998; 33; 1579-1587.
27. Tsuji N, Ishiguro S, Kasugai T et al. Risk factor for lymph node metastasis of submucosal invasive carcinoma. Stomach Intestine (I Chou) 1997; 32; 41-47.
28. Yoshikawa A, Inada K, Yamachika T, Shimizu N, Kaminishi M, Tatematsu M. Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression. Gastric Cancer 1998; 1; 134-141.
29. Egashira Y, Shimoda T, Ikegami M. Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol. Int. 1999; 49; 55-61.
30. Watanabe G, Watanabe H, Ajioka Y, Shiroshita H, Nishikura K. Well-differentiated type adenocarcinomas of gastric mucin phenotype transform into intestinal type carcinomas. Stomach Intestine (I Chou) 2003; 38; 693-700.
31. Bamba M, Sugihara H, Kushima R et al. Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach. Virchows Arch. 2001; 438; 49-56.
32. Yamachika T, Inada K, Fujimitsu Y et al. Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch. 1997; 431; 103-110.
33. Sugihara H, Hattori T, Fukuda M, Fujita S. Cell proliferation and differentiation in intramucosal and advanced signet ring cell carcinomas of human stomach. Virchows Arch. A 1987; 411; 117-127.
34. Sariba M, Borchard F, Hengels KJ. Histogenetical investigations of adenocarcinomas of the esophagogastric junction. Pathol. Res. Pract. 1993; 189; 530-535.
35. Kushima R, Lohe B, Borchard F. Differentiation towards gastric foveolar, mucopeptic and intestinal goblet cells in gallbladder adenocarcinomas. Histopathology 1996; 29; 443-448.