Suppression of low-density lipoprotein oxidation, vascular smooth muscle cell proliferation and migration by a herbal extract of Radix Astragali, Radix Codonopsis and Cortex Lycii

BMC Complementary and Alternative Medicine

Volumn 11, Issue , 2011, Pages

  Chan, Judy Y ^a   Koon, Johnny C ^a   Leung, Ping Chung ^a   Che, Chun Tao ^a   Fung, Kwok Pui ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Atherosclerosisvascular smooth muscle cellproliferation; migration

Indexed keywords

ASCORBIC ACID; CODONOPSIS EXTRACT; COPPER ION; CORTEX LYCII EXTRACT; LOW DENSITY LIPOPROTEIN; METHOPRENE; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR; RADIX ASTRAGALUS EXTRACT; UNCLASSIFIED DRUG; ANTIOXIDANT; HERBACEOUS AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORTEX LYCII; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; ERYTHROCYTE; HEMODIALYSIS; HEMOLYSIS; IC 50; LIPID PEROXIDATION; MEDICINAL PLANT; NONHUMAN; RADIX ASTRAGALI; RADIX CODONOPSIS; RAT; VASCULAR SMOOTH MUSCLE; ANIMAL; ASTRAGALUS PLANT; BARK; CELL CYCLE; CELL MOTION; CODONOPSIS; CULTURE TECHNIQUE; CYTOLOGY; LYCIUM; METABOLISM; OXIDATION REDUCTION REACTION; PHYTOTHERAPY; PLANT ROOT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ASTRAGALUS PLANT; ATHEROSCLEROSIS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CHOLESTEROL, LDL; CODONOPSIS; DRUGS, CHINESE HERBAL; ERYTHROCYTES; HEMOLYSIS; INHIBITORY CONCENTRATION 50; LIPID PEROXIDATION; LYCIUM; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION; PHYTOTHERAPY; PLANT BARK; PLANT ROOTS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79955014029     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-11-32     Document Type: Article

References (22)

1. Albright A. What is public health practice telling us about diabetes?. J Am Diet Assoc 2008, 108:S12-8. 10.1016/j.jada.2008.01.023, 18358248.
2. Bessesen DH. Update on obesity. J Clin Endocrinol Metab 2008, 93:2027-2034. 10.1210/jc.2008-0520, 18539769.
3. Vergès B. New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab 2005, 31:429-439. 10.1016/S1262-3636(07)70213-6, 16357786.
4. Krentz AJ. Lipoprotein abnormalities and their consequences for patients with type 2 diabetes. Diabetes Obes Metab 2003, 5:S19-27. 10.1046/j.1462-8902.2003.0310.x, 14984018.
5. Stewart CR, Tseng AA, Mok YF, Staples MK, Schiesser CH, Lawrence LJ, Varghese JN, Moore KJ, Howlett GJ. Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages. Biochemistry 2005, 44:9108-9116. 10.1021/bi050497v, 15966734.
6. Galle J, Lehmann-Bodem C, Hübner U, Heinloth A, Wanner C. CyA and OxLDL cause endothelial dysfunction in isolated arteries through endothelin-mediated stimulation of O(2)(-) formation. Nephrol Dial Transplant 2000, 15:339-346. 10.1093/ndt/15.3.339, 10692519.
7. Niedowicz DM, Daleke DL. The role of oxidative stress in diabetic complications. Cell Biochem Biophys 2005, 43:289-330. 10.1385/CBB:43:2:289, 16049352.
8. Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004, 84:1381-1478. 10.1152/physrev.00047.2003, 15383655.
9. Kingsley K, Huff JL, Rust WL, Carroll K, Martinez AM, Fitchmun M, Plopper GE. ERK1/2 mediates PDGF-BB-BB stimulated vascular smooth muscle cell proliferation and migration on laminin-5. Biochem Biophys Res Commun 2002, 293:1000-1006. 10.1016/S0006-291X(02)00331-5, 12051759.
10. Chan JY, Lam FC, Leung PC, Che CT, Fung KP. Anti-hyperglycemic and anti-oxidative effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytother Res 2009, 23:658-665. 10.1002/ptr.2694, 19107854.
11. Chan JY, Leung PC, Che CT, Fung KP. Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic β-cells: An implication for its treatment of diabetes mellitus. Phytother Res 2008, 22:190-196. 10.1002/ptr.2285, 17726733.
12. State Pharmacopoeia Commission Pharmacopoeia of the People's Republic of China. 2005, Chemical Industry Press, Beijing, China, State Pharmacopoeia Commission.
13. Chan JY, Tang PM, Hon PM, Au SW, Tsui SK, Waye MM, Kong SK, Mak TC, Fung KP. Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. Planta Med 2006, 72:28-33. 10.1055/s-2005-873149, 16450292.
14. Chan JY, Siu KP, Fung KP. Effect of arsenic trioxide on multidrug resistant hepatocellular carcinoma cells. Cancer Lett 2006, 236:250-258. 10.1016/j.canlet.2005.05.017, 15982806.
15. Lähteenmäki TA, Korpela R, Tikkanen MJ, Karjala K, Laakso J, Solatunturi E, Vapaatalo H. Proliferative effects of oxidized low-density lipoprotein on vascular smooth muscle cells: role of dietary habits. Life Sci 1998, 63:995-1003. 10.1016/S0024-3205(98)00361-0, 9749822.
16. Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis 1998, 141:1-15.
17. Bicknell KA, Surry EL, Brooks G. Targeting the cell cycle machinery for the treatment of cardiovascular disease. J Pharm Pharmacol 2003, 55:571-591.
18. Myllärniemi M, Calderon L, Lemström K, Buchdunger E, Häyry P. Inhibition of platelet-derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation. FASEB J 1997, 11:1119-1126.
19. Graf K, Xi XP, Yang D, Fleck E, Hsueh WA, Law RE. Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells. Hypertension 1997, 29:334-339.
20. Schafer KA. The cell cycle: a review. Vet Pathol 1998, 35:461-478. 10.1177/030098589803500601, 9823588.
21. Dong LH, Wen JK, Miao SB, Jia ZH, Hu HJ, Sun RH, Wu YL, Han M. Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRbeta-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia. Cell Res 2010, 20:1252-1262. 10.1038/cr.2010.111, 20661261.
22. Kim TJ, Lee JH, Lee JJ, Yu JY, Hwang BY, Ye SK, Li S, Li G, Pyo MY, Yun YP. Corynoxeine isolated from the Hook of Uncaria rhynchophylla inhibits rat aotic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. Biol Pharm Bull 2008, (31):2073-2078.