Pregnancy outcome after preimplantation genetic screening or natural conception in couples with unexplained recurrent miscarriage: A systematic review of the best available evidence

Fertility and Sterility

Volumn 95, Issue 6, 2011, Pages

  Musters, Anna M ^a,b   Repping, Sjoerd ^a   Korevaar, Johanna C ^a   Mastenbroek, Sebastiaan ^a   Limpens, Jacqueline ^a   Van Der Veen, Fulco ^a   Goddijn, Mariëtte ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Habitual abortion; live birth rates; miscarriage rates; natural conception; preimplantation genetic screening

Indexed keywords

ARTICLE; CONCEPTION; GENETIC SCREENING; HUMAN; LIVE BIRTH; PREGNANCY OUTCOME; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

EID: 79955010080     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.12.022     Document Type: Article

References (70)

1. R. Rai, and L. Regan Recurrent miscarriage Lancet 368 2006 601 611 (Pubitemid 44209184)
2. L. Gianaroli, M.C. Magli, A.P. Ferraretti, C. Tabanelli, C. Trombetta, and E. Boudjema The role of preimplantation diagnosis for aneuploidies Reprod Biomed Online 4 Suppl 3 2002 31 36
3. L. Werlin, I. Rodi, A. Decherney, E. Marello, D. Hill, and S. Munné Preimplantation genetic diagnosis as both a therapeutic and diagnostic tool in assisted reproductive technology Fertil Steril 80 2003 467 468 (Pubitemid 36959815)
4. C. Rubio, T. Pehlivan, L. Rodrigo, C. Simón, J. Remohí, and A. Pellicer Embryo aneuploidy screening for unexplained recurrent miscarriage: a minireview Am J Reprod Immunol 53 2005 159 165 (Pubitemid 40425745)
5. S. Munne, S. Chen, J. Fischer, P. Colls, X. Zheng, and J. Stevens Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages Fertil Steril 84 2005 331 335 (Pubitemid 41125253)
6. A. Mantzouratou, A. Mania, E. Fragouli, L. Xanthopoulou, S. Tashkandi, and K. Fordham Variable aneuploidy mechanisms in embryos from couples with poor reproductive histories undergoing preimplantation genetic screening Hum Reprod 22 2007 1844 1853 (Pubitemid 47062751)
7. J.C. Harper, K. Boelaert, J. Geraedts, G. Harton, W.G. Kearns, and C. Moutou ESHRE PGD Consortium data collection V: cycles from January to December 2002 with pregnancy follow-up to October 2003 Hum Reprod 21 2006 3 21 (Pubitemid 41794287)
8. V. Goossens, G. Harton, C. Moutou, P.N. Scriven, J. Traeger-Synodinos, and K. Sermon ESHRE PGD Consortium data collection VIII: cycles from January to December 2005 with pregnancy follow-up to October 2006 Hum Reprod 23 2008 2629 2645
9. A.R. Thornhill, C.E. de Die-Smulders, J.P. Geraedts, J.C. Harper, G.L. Harton, and S.A. Lavery ESHRE PGD Consortium 'Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)' Hum Reprod 20 2005 35 48
10. The Practice Committee of the Society for Assisted Reproductive Technology and the Practice Committee of the American Society of Reproductive Medicine Preimplantation genetic testing: a Practice Committee opinion Fertil Steril 90 2008 S136 S146
11. E. Jauniaux, R.G. Farquharson, O.B. Christiansen, and N. Exalto Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage Hum Reprod 21 2006 2216 2222 (Pubitemid 44530592)
12. C. Simon, C. Rubio, F. Vidal, C. Gimenez, C. Moreno, and J.J. Parrilla Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage Reprod Fertil Dev 10 1998 87 92 (Pubitemid 28383844)
13. F. Vidal, C. Gimenez, C. Rubio, C. Simón, A. Pellicer, and J. Santaló FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage J Assist Reprod Genet 15 1998 310 313 (Pubitemid 28223994)
14. A. Pellicer, C. Rubio, F. Vidal, Y. Mínguez, C. Giménez, and J. Egozcue In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos Fertil Steril 71 1999 1033 1039 (Pubitemid 29252492)
15. C. Rubio, C. Simon, F. Vidal, L. Rodrigo, T. Pehlivan, and J. Remohí Chromosomal abnormalities and embryo development in recurrent miscarriage couples Hum Reprod 18 2003 182 188 (Pubitemid 36138874)
16. T. Pehlivan, C. Rubio, L. Rodrigo, J. Remohí, A. Pellicer, and C. Simón Preimplantation genetic diagnosis by fluorescence in situ hybridization: clinical possibilities and pitfalls J Soc Gynecol Invest 10 2003 315 322 (Pubitemid 37102840)
17. C. Rubio, L. Rodrigo, I. Perez-Cano, A. Mercader, E. Mateu, and P. Buendía FISH screening of aneuploidies in preimplantation embryos to improve IVF outcome Reprod Biomed Online 11 2005 497 506 (Pubitemid 41762072)
18. M. Twisk, S. Mastenbroek, A. Hoek, M.J. Heineman, F. van der Veen, and P.M. Bossuyt No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy Hum Reprod 23 2008 2813 2817
19. C. Rubio, P. Buendía, L. Rodrigo, A. Mercader, E. Mateu, and V. Peinado Prognostic factors for preimplantation genetic screening in repeated pregnancy loss Reprod Biomed Online 18 2009 687 693
20. S. Kahraman, M. Benkhalifa, E. Donmez, A. Biricik, S. Sertyel, and N. Findikli The results of aneuploidy screening in 276 couples undergoing assisted reproductive techniques Prenat Diagn 24 2004 307 311 (Pubitemid 38480668)
21. J. Garrisi, J. Cohen, K.M. Ferry, P. Colls, M.G. Garrisi, and S. Munne Preimplantation genetic diagnosis (PGD) effectively reduces idiopathic recurrent pregnancy loss (RPL) among patients with up to five previous miscarriages after natural conception Fertil Steril 88 2007 S85
22. J.C. Harper, C. Die-Smulders, V. Goossens, G. Harton, C. Moutou, and S. Repping ESHRE PGD consortium data collection VII: cycles from January to December 2004 with pregnancy follow-up to October 2005 Hum Reprod 23 2008 741 755 (Pubitemid 351651188)
23. J.G. Garrisi, P. Colls, K.M. Ferry, X. Zheng, M.G. Garrisi, and S. Munne Effect of infertility, maternal age, and number of previous miscarriages on the outcome of preimplantation genetic diagnosis for idiopathic recurrent pregnancy loss Fertil Steril 92 2009 288 296
24. M. Wilding, R. Forman, G. Hogewind, L. Di Matteo, F. Zullo, and F. Cappiello Preimplantation genetic diagnosis for the treatment of failed in vitro fertilization-embryo transfer and habitual abortion Fertil Steril 81 2004 1302 1307 (Pubitemid 38609315)
25. P. Platteau, C. Staessen, A. Michiels, A. Van Steirteghem, I. Liebaers, and P. Devroey Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages Fertil Steril 83 2005 393 397 (Pubitemid 40221794)
26. L. Levine Habitual abortion. A controlled study of progestational therapy West J Surg Obstet Gynecol 72 1964 30 36
27. J.W. Goldzieher Double-blind trial of a progestin in habitual abortion JAMA 188 1964 651 654
28. E.R. Burton, and E.G. Wachtel A clinical trial and cytological assessment of enol Luteovis in the treatment of threatened and recurrent abortion J Obstet Gynaecol Br Commonw 74 1967 533 536
29. J. Svigos Preliminary experience with the use of human chorionic gonadotrophin therapy in women with repeated abortion Clin Reprod Fertil 1 1982 131 135
30. R.F. Harrison Treatment of habitual abortion with human chorionic gonadotropin: results of open and placebo-controlled studies Eur J Obstet Gynecol Reprod Biol 20 1985 159 168 (Pubitemid 15015456)
31. J.F. Mowbray, C. Gibbings, and H. Liddell Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells Lancet 1 1985 941 943 (Pubitemid 15123957)
32. M.N. Cauchi, D. Lim, D.E. Young, M. Kloss, and R.J. Pepperell Treatment of recurrent aborters by immunization with paternal cells - Controlled trial Am J Reprod Immunol 25 1991 16 17
33. H.N. Ho, T.J. Gill, H.J. Hsieh, J.J. Jiang, T.Y. Lee, and C.Y. Hsieh Immunotherapy for recurrent spontaneous abortions in a Chinese population Am J Reprod Immunol 25 1991 10 15
34. O.B. Christiansen, B.S. Christiansen, M. Husth, C. Jersild, and N. Grunnet Prospective study of anticardiolipin antibodies in immunized and untreated women with recurrent spontaneous abortions Fertil Steril 58 1992 328 334
35. R.F. Harrison Human chorionic gonadotrophin (hCG) in the management of recurrent abortion: results of a multi-centre placebo-controlled study Eur J Obstet Gynecol Reprod Biol 47 1992 175 179 (Pubitemid 23018382)
36. P.A. Gatenby, K. Cameron, R.J. Simes, S. Adelstein, M.J. Bennett, and R.P. Jansen Treatment of recurrent spontaneous abortion by immunization with paternal lymphocytes: results of a controlled trial Am J Reprod Immunol 29 1993 88 94 (Pubitemid 23152554)
37. J. Collins, and R. Roberts Reports of independent analyses of data from the Worldwide Prospective Collaborative Study on immunotherapy for unexplained recurrent spontaneous abortion. Immunotherapy for recurrent spontaneous abortion: analysis 1 Am J Reprod Immunol 32 1994 275 280
38. C.B. Coulam Alternative treatment to lymphocyte immunization for treatment of recurrent spontaneous abortion. Immunotherapy with intravenous immunoglobulin for treatment of recurrent pregnancy loss Am J Reprod Immunol 32 1994 286 289
39. C.B. Coulam Immunotherapy with intravenous immunoglobulin for treatment of recurrent pregnancy loss: American experience Am J Reprod Immunol 32 1994 286 289
40. O.B. Christiansen, O. Mathiesen, M. Husth, K.L. Rasmussen, H.J. Ingerslev, and J.G. Lauritsen Placebo-controlled trial of treatment of unexplained secondary recurrent spontaneous abortions and recurrent late spontaneous abortions with i.v. immunoglobulin Hum Reprod 10 1995 2690 2695
41. C.B. Coulam, L. Krysa, J.J. Stern, and M. Bustillo Intravenous immunoglobulin for treatment of recurrent pregnancy loss Am J Reprod Immunol 34 1995 333 337
42. S. Quenby, and R.G. Farquharson Human chorionic gonadotropin supplementation in recurring pregnancy loss: a controlled trial Fertil Steril 62 1994 708 710 (Pubitemid 24307561)
43. K. Clifford, R. Rai, and L. Regan Future pregnancy outcome in unexplained recurrent first trimester miscarriage Hum Reprod 12 1997 387 389 (Pubitemid 27129408)
44. B. Jablonowska, A. Selbing, M. Palfi, S. Kjellberg, and A.L. Selbing Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study Hum Reprod 14 1999 838 841 (Pubitemid 29131273)
45. H.J. Carp, V. Toder, E. Gazit, R. Ahiron, A. Torchinski, and S. Mashiach Further experience with intravenous immunoglobulin in women with recurrent miscarriage and a poor prognosis Am J Reprod Immunol 46 2001 268 273 (Pubitemid 32926907)
46. O.B. Christiansen, B. Pedersen, A. Rosgaard, and M. Husth A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a therapeutic effect in women with secondary recurrent miscarriage Hum Reprod 17 2002 809 816 (Pubitemid 34232457)
47. R. Rai, M. Backos, S. Elgaddal, A. Shlebak, and L. Regan Factor V Leiden and recurrent miscarriage - prospective outcome of untreated pregnancies Hum Reprod 17 2002 442 445 (Pubitemid 34168455)
48. H. Carp, M. Dolitzky, and A. Inbal Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia J Thromb Haemost 1 2003 433 438
49. S. Dendrinos, E. Makrakis, D. Botsis, D. Chassiakos, S. Baka, and G. Creatsas A study of pregnancy loss in 352 women with recurrent miscarriages Arch Gynecol Obstet 271 2005 235 239 (Pubitemid 40562102)
50. M.Y. El-Zibdeh Dydrogesterone in the reduction of recurrent spontaneous abortion J Steroid Biochem Mol Biol 97 2005 431 434 (Pubitemid 41691882)
51. A.F. Amin, O.M. Shaaban, and M.A. Bediawy N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss Reprod Biomed Online 17 2008 722 726
52. M. Fawzy, T. Shokeir, M. El-Tatongy, O. Warda, A.A. El-Refaiey, and A. Mosbah Arch Gynecol Obstet 278 2008 35 38
53. A.M. Badawy, M. Khiary, L.S. Sherif, M. Hassan, A. Ragab, and I. Abdelall J Obstet Gynaecol 28 2008 280 284
54. M.T. Illeni, G. Marelli, F. Parazzini, B. Acaia, L. Bocciolone, and M. Bontempelli Immunotherapy and recurrent abortion: a randomized clinical trial Hum Reprod 9 1994 1247 1249 (Pubitemid 24223989)
55. H. Carp, B. Feldman, G. Oelsner, and E. Schiff Parental karyotype and subsequent live births in recurrent miscarriage Fertil Steril 81 2004 1296 1301 (Pubitemid 38609314)
56. T. Nonaka, K. Takakuwa, I. Ooki, M. Akashi, T. Yokoo, and A. Kikuchi Results of immunotherapy for patients with unexplained primary recurrent abortions - prospective non-randomized cohort study Am J Reprod Immunol 58 2007 530 536 (Pubitemid 350091190)
57. D.M. Gilchrist, J.E. Livingston, J.A. Hurlburt, and R.D. Wilson Recurrent spontaneous pregnancy loss. Investigation and reproductive follow-up J Reprod Med 36 1991 184 188
58. M. Diejomaoh, J. Jirous, M. Al-Azemi, S. Baig, M. Gupta, and A. Tallat The relationship of recurrent spontaneous miscarriage with reproductive failure Med Princ Pract 12 2003 107 111 (Pubitemid 36356888)
59. H.J. Carp, Y. Hass, M. Dolicky, M. Goldenberg, S. Mashiach, and J. Rabinovici The effect of serum follicular phase luteinizing hormone concentrations in habitual abortion: correlation with results of paternal leukocyte immunization Hum Reprod 10 1995 1702 1705
60. H. Carp, M. Dolitzky, I. Tur-Kaspa, and A. Inbal Hereditary thrombophilias are not associated with a decreased live birth rate in women with recurrent miscarriage Fertil Steril 78 2002 58 62 (Pubitemid 34722671)
61. H. Lashen, K. Fear, and D.W. Sturdee Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study Hum Reprod 19 2004 1644 1646 (Pubitemid 38997196)
62. M. Tulppala, T. Palosuo, T. Ramsay, A. Miettinen, R. Salonen, and O. Ylikorkala A prospective study of 63 couples with a history of recurrent spontaneous abortion: contributing factors and outcome of subsequent pregnancies Hum Reprod 8 1993 764 770 (Pubitemid 23164298)
63. M. Dolitzky, A. Inbal, Y. Segal, A. Weiss, B. Brenner, and H. Carp A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages Fertil Steril 86 2006 362 366 (Pubitemid 44118966)
64. O.B. Christansen, O. Mathiesen, M. Husth, J.G. Lauritsen, and N. Grunnet Placebo-controlled trial of active immunization with third party leukocytes in recurrent miscarriage Acta Obstet Gynecol Scand 73 1994 261 268 (Pubitemid 24074447)
65. K. Clifford, R. Rai, H. Watson, S. Franks, and L. Regan Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial Br Med J 312 1996 1508 1511 (Pubitemid 26178256)
66. M.D. Stephenson, K. Dreher, E. Houlihan, and V. Wu Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: a prospective, randomized, double-blinded, placebo-controlled trial Am J Reprod Immunol 39 1998 82 88 (Pubitemid 28062279)
67. C. Ober, T. Karrison, R.R. Odem, R.B. Barnes, D.W. Branch, and M.D. Stephenson Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial Lancet 354 1999 365 369 (Pubitemid 29355752)
68. R. Ramhorst, E. Agriello, S. Zittermann, M. Pando, J. Larriba, and M. Irigoyen Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion? Am J Reprod Immunol 44 2000 129 135
69. M.K. Pandey, and S. Agrawal Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion IntI Immunopharmacol 4 2004 289 298 (Pubitemid 38296357)
70. F. Scarpellini, and M. Sbracia Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial Hum Reprod 24 2009 2701 2708