Magnetic microparticles for endovascular aneurysm treatment: In vitro and in vivo experimental results

Neurosurgery

Volumn 68, Issue 5, 2011, Pages 1388-1397

  Oechtering, Johanna ^a,b   Kirkpatrick, Peter J ^c   Ludolph, Alexander G K ^a,d   Hans, Franz J ^a   Sellhaus, Bernd ^a   Spiegelberg, Andreas ^e   Krings, Timo ^a,f  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d KLINIKUM FULDA   (Germany)

^e Spiegelberg Gmbh and Co KG   (Germany)

^f TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Cerebral aneurysm; Experimental interventional neuroradiology; Magnetic microparticles

Indexed keywords

ELASTASE; MAGNETITE; NEODYMIUM; SILICONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL EMBOLISM; CATHETERIZATION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DISEASE MODEL; ENDOVASCULAR SURGERY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTRACRANIAL ANEURYSM; MAGNETIC FIELD; MAGNETIC MICROPARTICLE; MEMBRANE MICROPARTICLE; NONHUMAN; PRIORITY JOURNAL; RECANALIZATION; SOLID STATE;

ANIMALS; ENDOVASCULAR PROCEDURES; INJECTIONS, INTRA-ARTERIAL; INTRACRANIAL ANEURYSM; MAGNETIC FIELD THERAPY; MAGNETITE NANOPARTICLES; MICROSPHERES; RABBITS; TREATMENT OUTCOME;

EID: 79955003377     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e3182125eb0     Document Type: Article

References (45)

1. Van Gijn J, Kerr RS, Rinkel G. Subarachnoid haemorrhage. Lancet. 2007;369(9558):306-318. (Pubitemid 46136491)
2. Molyneux A, Kerr R, Stratton I, ofneurosurgical clipping versus an endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial. Lancet. 2002;360 et al; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International Subarachnoid Aneurysm Trial (ISAT) (9342):1267-1274. (Pubitemid 35284616)
3. Krings T, Hans FJ, Möller-Hartmann W, et al. Treatment of experimentally induced aneurysms with stents. Neurosurgery. 2005;56(6):1347- 1359. (Pubitemid 40770464)
4. Zubillaga AF, Guglielmi G, Vinuela F, Duckwiler G. Endovascular occlusion of intracranial aneurysms with electrically detachable coils: correlation of aneurysm neck size and treatment results. AJNR Am J Neuroradiol. 1994;15(5):815-820. (Pubitemid 24153770)
5. Malisch TW, Guglielmi G, Vinuela F, et al. Intracranial aneurysms treated with the Guglielmi detachable coil: midterm clinical results in a consecutive series of 100 patients. J Neurosurg. 1997;87(2):176-183. (Pubitemid 27349100)
6. Pierot L, Spelle L, Vitry F; ATENA Investigators. Immediate clinical outcome of patients harboring unruptured intracranial aneurysms treated by endovascular approach: results ofthe ATENA study. Stroke. 2008;39(9):2497-2504.
7. Dutz S. Magnetic Nanoparticles for Biomedical Heating Applications. Hamburg, Germany: Verlag Dr Kovac; 2008.
8. Holzapfel V. Fluorescinatingand Magnetic Polymer Nanoparticles: Functionalization and Biomedical Application. Saarbrücken, Germany: VDM Verlag Dr Müller; 2008.
9. Bacon BR, Stark DD, Park CH, et al. Ferrite particles: a new magnetic resonance imaging contrast agent: lack of acute or chronic hepatotoxicity after intravenous administration.JLab Clin Med. 1987;110(2):164-171. (Pubitemid 17139449)
10. Lübbe AS, Bergemann C, Riess H, et al. Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solidtumors. Cancer Res. 1996;56(20):4686-4693. (Pubitemid 26338071)
11. Lübbe AS, Bergemann C, Huhnt W, et al. Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res. 1996;56(20):4694-4701. (Pubitemid 26338072)
12. Weissleder R, Stark DD, Engelstad BL, et al. Superparamagnetic iron oxides: pharmacokinetics and toxicity. AJR Am JRoentgenol. 1989;152 (1):167-173. (Pubitemid 19024086)
13. McBain SC, Yiu HH, Dobson J. Magnetic nanoparticles for gene and drug delivery. Int JNanomedicine. 2008;3(2):169-180. (Pubitemid 352037850)
14. Alexiou C, Arnold W, Klein RJ, et al. Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 2000;60(23):6641-6648.
15. Berry CC, Curtis ASG. Functionalisation of magnetic nanoparticles for applica-tions in biomedicine. J Phys D Appl Phys. 2003;36:198-206.
16. Koda J, Venook A, Walser E, et al. A multicenter phase I/II trial of hepatic intra-arterial delivery of doxorubicin hydrochloride adsorbed to magnetic targeted carriers in patients with hepatocellular carcinoma. Eur J Cancer. 2002;38(suppl 7):18.
17. Wilson MW, Kerlan RK Jr, Fidelman NA, et al. Hepatocellular carcinoma: re-gional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite: initial experience with four patients. Radiology. 2004;230(1):287-293. (Pubitemid 37549815)
18. Johannsen M, Gneveckow U, Thiesen B, et al. Thermotherapy ofprostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional tem-perature distribution. Eur Urol. 2007;52(6):1653-1661.
19. Jordan A, Maier-Hauff K. Magnetic nanoparticles for intracranial thermotherapy. J Nanosci Nanotechnol. 2007;7(12):4604-4606.
20. Maier-Hauff K, Rothe R, Scholz R, et al. Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme. J Neurooncol. 2007;81(1):53-60. (Pubitemid 44963989)
21. Udrea LE, Strachan NJ, Badescu V, Rotariu O. An in vitro study of magnetic particle targeting in small blood vessels. Phys Med Biol. 2006;51(19):4869-4881. (Pubitemid 44429849)
22. Furlani EP, Ng KC.Analytical model of magnetic nanoparticle transport and capture in the microvasculature. Phys Rev E Stat Nonlin Soft Matter Phys. 2006;73(6)(pt 1):06 1919.
23. Khalessi A, Liu C, Apuzzo M. Neurosurgery and quantum dots, part I: state ofthe art. Neurosurgery. 2009;64(4):1015-1028.
24. Radomski A, Jurasz P, Alonso-Escolano D, et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol. 2005;146(6):882-893. (Pubitemid 41622255)
25. Tartaj P, Del Puerto Morales M, Veintemillas-Verdaguer S, Gonzalez-Carreno T, Serna CJ. The preparation of magnetic nanoparticles for applications in bio-medicine. J Phys D Appl Phys. 2003;36:182-197.
26. Lübbe AS, Bergemann C, Brook J, McClure DG. Physiological aspects in mag-netic drug targeting. J Magn Magn Mater. 1999;194(1):149.
27. Alksne JF, Fingerhut A, Rand R. Magnetic probe for the stereotactic thrombosis of intracranial aneurysms. J Neurol Neurosurg Psychiat. 1967;30(2): 159-162.
28. Alksne JF, Smith R. Iron-acrylic compound for stereotaxic aneurysm thrombosis. J Neurosurg. 1977;47(2):137-141. (Pubitemid 8133076)
29. Smith RW, Alksne JF. Stereotaxic thrombosis ofinaccessible intracranial aneur-ysms. JNeurosurg. 1977;47(6):833-839. (Pubitemid 8232048)
30. Khilko VA. Artificial embolization of cerebral arteriovenous aneurysms via the vertebro-basilar system [in Russian]. Vopr Neirokhir. 1976;May-June(3): 15-20.
31. Krings T, Möller-Hartmann W, Hans FJ, et al. A refined method for creating saccular aneurysms in the rabbit. Neuroradiology. 2003;45(7):423-429. (Pubitemid 36944053)
32. Voltairas PA, Fotiadis DI, Michalis LK. Hydrodynamics of magnetic drug tar-geting. J Biomech. 2002;35(6):813-821.
33. Hans FJ, Krings T, Möller-Hartmann W, et al. Endovascular treatment of experimentally induced aneurysms in rabbits using stents: a feasibility study. Neuroradiology. 2003;45(7):430-434. (Pubitemid 36944054)
34. Hans FJ, Möller-Hartmann W, Brunn A, Schmitz-Rode T, Thron A, Krings T. Treatment of wide-necked aneurysms with balloon-expandable polyurethane-covered stent grafts: experience in an animal model. Acta Neurochir (Wien). 2005;147(8):871-876. (Pubitemid 41103967)
35. Abruzzo T, Shengelaia GG, Dawson RC III, Owens DS, Cawley CM, Gravanis MB. Histologic and morphologic comparison of experimental aneurysms with human intracranial aneurysms. AJNR Am J Neuroradiol. 1998;19(7):1309-1314. (Pubitemid 30418679)
36. Kallmes DF, Helm GA, Hudson SB, et al. Histologic evaluation ofplatinum coil embolization in an aneurysm model in rabbits. Radiology. 1999;213(1):217-222. (Pubitemid 29470431)
37. Manning PJ, Ringler DH, Newcomer CE. The Biology of the Laboratory Rabbit. 2nd ed. San Diego, CA: Academic Press; 1994.
38. Heilman CB, Kwan ES, Wu JK. Aneurysm recurrence following endovascular balloon occlusion. J Neurosurg. 1992;77(2):260-264.
39. Spetzger U, Reul J, Weis J, Bertalanffy H, Gilsbach JM. Endovascular coil em-bolization of microsurgically produced experimental bifurcation aneurysms in rabbits. Surg Neurol. 1998;49(5):491-494. (Pubitemid 28213357)
40. Alexiou C, Jurgons R, Schmid RJ, et al. Magnetic drug targeting: biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment. JDrug Target. 2003;11(3):139-149. (Pubitemid 37236327)
41. Alexiou C, Jurgons R, Schmid R, et al. Magnetic drug targeting: a new approach in locoregional tumor therapy with chemotherapeutic agents: experimental animal studies. HNO. 2005;53(7):618-622. (Pubitemid 41151554)
42. Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology. 1988;168(2):297-302.
43. Frösen J, Piippo A, Paetau A, et al. Growth factor receptor expression and re-modeling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture. Neurosurgery. 2006;58(3):534-541.
44. Krings T, Lasjaunias PL, Geibprasert S, Pereira V, Hans FJ. The aneurysmal wall: the key to a subclassification ofintracranial arterial aneurysm vasculopathies? Interv Neuroradiol. 2008;14(Suppl 1):39-47.
45. Niemelä M, Frösen J, Hernesniemi J, Dashti R, Palotie A. Molecular pathology of aneurysms. Surg Neurol. 2008;70(1):36-38.