Use of [18F]fluorodeoxyglucose and the ATLAS small animal PET scanner to examine cerebral functional activation by whisker stimulation in unanesthetized rats

Nuclear Medicine Communications

Volumn 32, Issue 5, 2011, Pages 336-342

  Ravasi, Laura ^a,c   Shimoji, Kazuaki ^a,d   Soto Montenegro, Marisa L ^a,f   Esaki, Takanori ^b,g   Seidel, Jurgen ^a,e   Sokoloff, Louis ^b   Schmidt, Kathleen ^b  

^a Clinical Center   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d University School of Medicine   (Japan)

^e Hospital General Gregorio Marañón ^*

^f HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^g JUNTENDO UNIVERSITY SHIZUOKA HOSPITAL   (Japan)

Author keywords

PET; small animal imaging; whisker stimulation

Indexed keywords

CARBON 14; FLUORODEOXYGLUCOSE F 18; CARBON; DEOXYGLUCOSE; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN FUNCTION; CONTROLLED STUDY; IN VIVO STUDY; MALE; NERVE CELL; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; SOMATOSENSORY CORTEX; STIMULATION; ANIMAL; GLUCOSE BLOOD LEVEL; METABOLISM; METHODOLOGY; PHYSIOLOGY; SCINTISCANNING; VIBRISSA;

ANIMALS; AUTORADIOGRAPHY; BLOOD GLUCOSE; CARBON RADIOISOTOPES; DEOXYGLUCOSE; FLUORODEOXYGLUCOSE F18; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; SOMATOSENSORY CORTEX; VIBRISSAE;

EID: 79954987488     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e3283447292     Document Type: Article

References (19)

1. Sokoloff L. Energetics of functional activation in neural tissues. Neurochem Res 1999; 24:321-329. (Pubitemid 29067977)
2. Adachi K, Takahashi S, Melzer P, Campos KL, Nelson T, Kennedy C, et al. Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. Am J Physiol 1994; 267:H2155-H2162.
3. Melzer P, Van der Loos H, Dorfl J, Welker E, Robert P, Emery D, et al. A magnetic device to stimulate selected whiskers of freely moving or restrained small rodents: its application in a deoxyglucose study. Brain Res 1985; 348:229-240. (Pubitemid 16231706)
4. McCasland JS, Carvell GE, Simons DJ, Woolsey TA. Functional asymmetries in the rodent barrel cortex. Somatosens Mot Res 1991; 8:111-116.
5. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 1977; 28:897-916. (Pubitemid 8098854)
6. Nikolaus S, Beu M, Wirrwar A, Vosberg H, Müller H-W, Larisch R. The contribution of small animal positron emission tomography to the neurosciences: a critical evaluation. Rev Neurosci 2004; 15:131-156. (Pubitemid 38858894)
7. Schmidt K, Smith CB. Resolution, sensitivity and precision with autoradiography and small animal positron emission tomography: implications for functional brain imaging in animal research. Nucl Med Biol 2005; 32:719-725. (Pubitemid 41502977)
8. Seidel J, Vaquero J, Green MV. Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: comparison to simulated LSO scanners without depth-of-interaction capability. IEEE Trans Nucl Sci 2003; 50:1347-1350.
9. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 1986; 27:235-238. (Pubitemid 17024868)
10. Johnson CA, Seidel J, Vaquero JJ, Pascau J, Desco M, Green MV. Exact positioning for OSEM reconstructions on the ATLAS depth-of-interaction small animal scanner. Molecular Imaging and Biology 2002; 4 (Suppl 1):22.
11. Soncrant TT, Holloway HW, Stipetic M, Rapoport SI. Cerebral glucose utilization in rats is not altered by hindlimb restraint or by femoral artery and vein cannulation. J Cereb Blood Flow Metab 1988; 8:720-726.
12. Crane AM, Porrino LJ. Adaptation of the quantitative 2-[14-C]deoxyglucose method for use in freely moving rats. Brain Research 1989; 499:87-92. (Pubitemid 19241614)
13. Kim J, Herrero P, Sharp T, Laforest R, Rowland DJ,Tai Y-C, et al. Minimally invasive method of determining blood input function from PET images in rodents. J Nucl Med 2006; 47:330-336. (Pubitemid 46780899)
14. Su K-H, Lee J-S, Li J-H, Yand Y-W, Liu R-S, Chen J-C. Partial volume correction ofthe microPET blood inputfunction using ensemble learning independent component analysis. Phys Med Biol 2009; 54:1823-1846.
15. Kornblum HI, Araujo DM, Annala AJ,Tatsukawa KJ, Phelps ME, Cherry SR. In-vivo imaging of neuronal activation and plasticity in the rat brain by high-resolution positron emission tomography (microPET). Nat Biotechnol 2000; 18:655-660. (Pubitemid 30415301)
16. Pain F, Besret L, Vaufrey F, Gregoire MC, Pinot L, Gervais P, et al. In-vivo quantification of localized neuronal activation and inhibition in the rat brain using dedicated high temporal-resolution beta+ sensitive microprobe. Proc Natl Acad Sci USA 2002; 99:10807-10812.
17. Matsumura A, Mizokawa S, Tanaka M, Wada Y, Nozaki S, Nakamura F, et al. Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: comparison between quantitative data obtained with microPETand ex-vivo autoradiography. Neuro Image 2003; 20:2040-2050. (Pubitemid 37543620)
18. Nakao Y, Itoh Y, Kuang TY, Cook M, Jehle J, Sokoloff L. Effects of anesthesia on functional activation of cerebral blood flow and metabolism. Proc Nat Acad Sci USA 2001; 98:7593-7598. (Pubitemid 32567993)
19. 18F-FDG, the ATLAS small animal PETscanner, and arterial blood sampling. J Nucl Med 2004; 45:665-672. (Pubitemid 47618598)