Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy

Pain Medicine

Volumn 12, Issue 4, 2011, Pages 571-576

  Perruchoud, Christophe ^a   Eldabe, Sam ^b   Durrer, Anne ^a   Bovy, Michèle ^a   Brookes, Morag ^b   Madzinga, Grace ^b   Garner, Fay ^b   Batterham, Alan M ^c   Menoud, Carole ^a   Jacobs, Myriam ^a   Gulve, Ash ^b   Buchser, Eric ^a  

^a Hospital of Morges   (Switzerland)

^b JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^c TEESSIDE UNIVERSITY   (United Kingdom)

Author keywords

Cerebrospinal Fluid; Flow Rate; Intrathecal; Pump; Quality of Life

Indexed keywords

BACLOFEN; BUPIVACAINE; CLONIDINE; HYDROMORPHONE; MIDAZOLAM; MORPHINE;

ANALGESIA; ANXIETY; ARTICLE; CEREBROSPINAL FLUID; CHRONIC PAIN; CLINICAL ARTICLE; CONTINUOUS INFUSION; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; FATIGUE; FEMALE; FLOW RATE; HEALTH STATUS; HUMAN; INFUSION RATE; MALE; MOBILIZATION; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SLEEP DISORDER; VISUAL ANALOG SCALE; WITHDRAWAL SYNDROME;

ANALGESIA; ANALGESICS, OPIOID; CHRONIC DISEASE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, SPINAL; MALE; PAIN; PAIN MEASUREMENT; QUALITY OF LIFE; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 79954969737     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2011.01088.x     Document Type: Article

References (24)

1. Smith TJ, Staats PS, Deer T, etal. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: Impact on pain, drug-related toxicity, and survival. J Clin Oncol 2002;20:4040-9.
2. Deer T, Krames ES, Hassenbusch SJ, etal. Polyanalgesic consensus conference 2007: Recommendations for the management of pain by intrathecal (intraspinal) drug delivery: Report of an interdisciplinary expert panel. Neuromodulation 2007;10:300-28.
3. Bernards CM. Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs. Anesthesiology 2006;105:169-78.
4. Nelissen RM. Fluid Mechanics of Intrathecal Drug Delivery. Lausanne: Federal Institute of Technology: Lausanne, Switzerland; 2008.
5. Buchser E, Durrer A, Chedel D, Mustaki JP. Efficacy of intrathecal bupivacaine: How important is the flow rate? Pain Med 2004;5:248-52.
6. Rabin R, de Charro F. EQ-5D: A measure of health status from the EuroQol Group. Ann Med 2001;33:337-43.
7. Wallace MS, Charapata SG, Fisher R, etal. Intrathecal ziconotide in the treatment of chronic nonmalignant pain: A randomized, double-blind, placebo-controlled clinical trial. Neuromodulation 2006;9:75-86.
8. Pickard AS, Wilke CT, Lin HW, Lloyd A. Health utilities using the EQ-5D in studies of cancer. Pharmacoeconomics 2007;25:365-84.
9. Walters SJ, Brazier JE. Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res 2005;14:1523-32.
10. Batterham AM, Hopkins WG. Making meaningful inferences about magnitudes. Int J Sports Physiol Perform 2006;1:50-7.
11. Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc 2009;41:3-13.
12. Shakespeare TP, Gebski VJ, Veness MJ, Simes J. Improving interpretation of clinical studies by use of confidence levels, clinical significance curves, and risk-benefit contours. Lancet 2001;357:1349-53.
13. Price DD, McGrath PA, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain 1983;17:45-56.
14. Scott J, Huskisson EC. Accuracy of subjective measurements made with or without previous scores: An important source of error in serial measurement of subjective states. Ann Rheum Dis 1979;38:558-9.
15. Campbell WI, Patterson CC. Quantifying meaningful changes in pain. Anaesthesia 1998;53:121-5.
16. Becker N, Bondegaard Thomsen A, Olsen AK, etal. Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center. Pain 1997;73:393-400.
17. Hoffman DL, Sadosky A, Dukes EM, Alvir J. How do changes in pain severity levels correspond to changes in health status and function in patients with painful diabetic peripheral neuropathy? Pain 2010;149:194-201.
18. Shafer SL, Shafer A. Spinal pharmacokinetics. In: Yaksh TL, ed. Spinal Drug Delivery. Amsterdam; Lausanne; New York; Oxford; Shannon; Singapore; Tokyo: Elsevier; 1999:271-95.
19. Hocking G, Wildsmith JA. Intrathecal drug spread. Br J Anaesth 2004;93:568-78.
20. King HK, Wooten DJ. Effects of drug dose, volume, and concentration on spinal anesthesia with isobaric tetracaine. Reg Anesth 1995;20:45-9.
21. Schmidt A, Schwagmeier R, Broja E, Nolte H. [The effect of volume and dosage of isobaric bupivacaine on the sensory spread of spinal anesthesia]. Reg Anaesth 1990;13:159-62.
22. Eisenach JC, Hood DD, Curry R, Shafer SL. Cephalad movement of morphine and fentanyl in humans after intrathecal injection. Anesthesiology 2003;99:166-73.
23. Shafer SL, Eisenach JC, Hood DD, Tong C. Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans. Anesthesiology 1998;89:1074-88.
24. Ummenhofer WC, Arends RH, Shen DD, Bernards CM. Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. Anesthesiology 2000;92:739-53.