Rapid evolution of arginine deiminase for improved anti-tumor activity

Applied Microbiology and Biotechnology

Volumn 90, Issue 1, 2011, Pages 193-201

  Ni, Ye ^a   Liu, Yongmei ^a   Schwaneberg, Ulrich ^b   Zhu, Leilei ^b   Li, Na ^a   Li, Lifeng ^a   Sun, Zhihao ^a  

^a JIANGNAN UNIVERSITY   (China)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Anti tumor; Arginine deiminase; Directed evolution; Hepatocellular carcinomas; pH optimum; Pseudomonas plecoglossicida

Indexed keywords

ANTI-TUMORS; ARGININE DEIMINASES; DIRECTED EVOLUTION; HEPATOCELLULAR; PH OPTIMUM; PSEUDOMONAS PLECOGLOSSICIDA;

ARGININE; DISEASES; PH; TUMORS;

AMINO ACIDS;

ARGININE; ARGININE DEIMINASE; DIACETYL OXIME; THIOSEMICARBAZIDE;

BACTERIUM; CANCER; DRUG; ENZYME ACTIVITY; HOMOLOGY; INHIBITOR; MUTATION; PH; PHYSIOLOGY; SERUM; TUMOR;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG PURIFICATION; DRUG SCREENING; ENZYME ACTIVITY; NONHUMAN; PH MEASUREMENT; POLYMERASE CHAIN REACTION; PSEUDOMONAS; PSEUDOMONAS PLECOGLOSSICIDA; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; ARGININE; BACTERIAL PROTEINS; DIRECTED MOLECULAR EVOLUTION; ENZYME STABILITY; HYDROLASES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; PSEUDOMONAS; SEQUENCE ALIGNMENT;

MYCOPLASMA ARGININI; PSEUDOMONAS PLECOGLOSSICIDA;

EID: 79954969731     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-3051-z     Document Type: Article

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