Platelet production and destruction in liver cirrhosis

Journal of Hepatology

Volumn 54, Issue 5, 2011, Pages 894-900

  Pradella, Paola ^a   Bonetto, Stefania ^a   Turchetto, Stefano ^a   Uxa, Laura ^a   Comar, Consuelo ^a   Zorat, Francesca ^a   De Angelis, Vincenzo ^a   Pozzato, Gabriele ^a,b  

^a UNIVERSITY HOSPITAL OF TRIESTE   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

Author keywords

Aplastic anemia; Glycocalicin; HBV; HCV; Idiopathic thrombocytopenic purpura; Liver cirrhosis; Thrombopoietin

Indexed keywords

ALCOHOL; GLYCOCALICIN; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; THIAZOLE ORANGE; THROMBOCYTE ANTIBODY; THROMBOPOIETIN;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; APLASTIC ANEMIA; ARTICLE; B LYMPHOCYTE; BLOOD DONOR; CELL DESTRUCTION; CLONAL VARIATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; THROMBOCYTOPOIESIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, APLASTIC; AUTOANTIBODIES; B-LYMPHOCYTES; BLOOD PLATELETS; CHILD; FEMALE; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SPLEEN; THROMBOPOIESIS; THROMBOPOIETIN;

EID: 79954930806     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.018     Document Type: Article

References (61)

1. P.J. Toghill, S. Green, and F. Ferguson Platelet dynamics in chronic liver disease with special reference to the role of the spleen J Clin Pathol 30 1977 367 371 (Pubitemid 8076145)
2. R.H. Aster Pooling of platelets in the spleen: role in the pathogenesis of 'hypersplenic' thrombocytopenia J Clin Invest 45 5 1966 645 657
3. P.A. McCormick, and K.M. Murphy Splenomegaly, hypersplenism and coagulation abnormalities in liver disease Baillires Best Pract Res Clin Gastroenterol 14 6 2000 1009 1031 (Pubitemid 32094271)
4. M.G. Mutchnik, E. Lerner, and H.O. Conn Effect of portacaval anastomosis on hypersplenism Dig Dis Sci 25 12 1980 929 938 (Pubitemid 11209200)
5. E. McAllister, S. Goode, A.G. Cordista, and A. Rosemurgy Partial portal decompression alleviates thrombocytopenia of portal hypertension Am Surg 61 2 1995 129 131
6. O.A. Alvarez, G.A. Lopera, V. Patel, C.E. Encarnacion, J.C. Palmaz, and M. Lee Improvement of thrombocytopenia due to hypersplenism after transjugular intrahepatic portosystemic shunt placement in cirrhotic patients Am J Gastroenterol 91 1 1996 134 137 (Pubitemid 26026052)
7. A.J. Sanyal, A.M. Freedman, P.P. Purdum, M.L. Shiffman, and V.A. Luketic The hematologic consequences of transjugular intrahepatic portosystemic shunts Hepatology 23 1 1996 32 39 (Pubitemid 26012088)
8. M. Gschwantler, J. Vavrik, A. Gebauer, S. Kriwanek, C. Schrutka-Kölbl, and J. Fleischer Course of platelet counts in cirrhotic patients after implantation of a transjugular intrahepatic portosystemic shunt - a prospective, controlled study J Hepatol 30 2 1999 254 259 (Pubitemid 29071189)
9. N. Jabbour, A. Zajiko, P. Orons, W. Irish, J.J. Fung, and R.R. Selby Does transjugular intrahepatic portosystemic shunt (TIPS) resolve thrombocytopenia associated with cirrhosis? Dig Dis Sci 43 11 1998 2459 2465
10. K. Yanaga, A.G. Tzakis, M. Shimada, W.E. Campbell, J.W. Marsh, and A.C. Stieber Reversal of hypersplenism following orthotopic liver transplantation Ann Surg 210 2 1989 180 183 (Pubitemid 19188708)
11. K. Kaushansky Thrombopoietin: the primary regulator of megakaryocyte and platelet production Thromb Haemost 74 1 1995 521 525
12. D.L. Eaton, and E.J. de Sauvage Thrombopoietin. The primary regulator of megakaryocytopoiesis and thrombopoieis Exp Hematol 25 1 1995 1 7 (Pubitemid 27063737)
13. W. Jelkmann The role of liver in the production of thrombopoietin compared with erythropoietin Eur J Gastroenterol Hepatol 13 7 2001 791 801 (Pubitemid 32656592)
14. M. Radosavljevic Thrombocytopenia in liver disease Can J Gastroenterol 14 Suppl. D 2000 60 66
15. H.S. Ballard Hematological complications of alcoholism Alcohol Clin Exp Res 13 5 1989 706 720 (Pubitemid 19270884)
16. R.E. Drews Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients Clin Chest Med 24 4 2003 607 622 (Pubitemid 38028497)
17. P. Bedossa, and T. Poynard An algorithm for the grading of activity in chronic hepatitis C The METAVIR Cooperative Study Group Hepatology 24 1996 289 293 (Pubitemid 26260021)
18. British Committee for Standards in Haematology General Haematology Task Force Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy Br J Haematol 120 2003 574 796
19. B.M. Camitta, E.D. Thomas, D.G. Nathan, R.P. Gale, K.J. Kopecky, and J.M. Rappeport A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia Blood 53 3 1979 504 514 (Pubitemid 9140408)
20. V. Vicente, P.J. Kostel, and Z.M. Ruggeri Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib J Biol Chem 263 34 1988 18473 18479 (Pubitemid 19005123)
21. S. Kunishima, K. Hayashi, S. Kobayashi, T. Naoe, and R. Ohno New enzyme-linked immunosorbent assay for glycocalinicin in plasma Clin Chem 37 2 1991 169 172 (Pubitemid 21892621)
22. J.H. Beer, L. Büchi, and B. Steiner Glycocalicin: a new assay the normal plasma levels and its potential usefulness in selected diseases Blood 83 3 1994 691 702 (Pubitemid 24043729)
23. P. Chomczynski, and N. Sacchi The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1 1987 156 159 (Pubitemid 17064313)
24. M. Peck-Radosavljevic Hypersplenism Eur J Gastroenterol Hepatol 13 4 2001 317 323 (Pubitemid 32319894)
25. M. Peck-Radosavljevic, J. Zacherl, Y.G. Meng, J. Pidlich, E. Lipinski, and F. Langle Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 27 1 1997 127 131 (Pubitemid 27357066)
26. K. Tanikawa Thrombopoietin and liver disease J Gastroenterol Hepatol 15 6 2000 579 580
27. T. Kawasaki, Takeshita A. Souda, Y. Kobayashi, M. Kikuyama, and F. Kikuyama Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis Am J Gastroenterol 94 7 1999 1918 1922 (Pubitemid 29315911)
28. I. Espanol, A. Gallego, J. Enriquez, N. Rabella, E. Lerma, and A. Hernández Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin Hepatogastroenterology 47 35 2000 1404 1406
29. E.-M. Wolber, and W. Jelkmann Thrombopoietin: the novel hepatic hormone News Physiol Sci 17 2002 6 10
30. J. Goulis, T.N. Chau, S. Jordan, A.B. Mehta, A. Watkinson, and K. Rolles Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation Gut 44 5 1999 754 758 (Pubitemid 29195930)
31. M. Peck-Radosavljevic, J. Zacherl, M. Wichlas, P. Sims, Y.G. Meng, and S. Panzer Thrombopoietic cytokines and reversal of thrombocytopenia after liver transplantation Eur J Gastroenterol Hepatol 11 2 1999 151 156 (Pubitemid 29103575)
32. M. Peck-Radosavljevic, M. Wichlas, J. Zacherl, G. Stiegler, P. Stohlawetz, and M. Fuchsjager Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production Blood 95 3 2000 795 801 (Pubitemid 30062698)
33. M. Kajihara, Y. Okazaki, S. Kato, H. Ishii, Y. Kawakami, and Y. Ikeda Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura J Gastroenterol Hepatol 22 1 2007 112 118 (Pubitemid 44953425)
34. L. Columbyova, M. Loda, and D.T. Scadden Thrombopoietin receptor expression in human cancer cell lines and primary tissues Cancer Res 55 16 1995 3509 3512
35. S.J. Hwang, J.C. Luo, C.P. Li, C.W. Chu, J.C. Wu, and C.R. Lai Thrombocytosis: a paraneoplastic syndrome in patients with hepatocellular carcinoma World J Gastroenterol 10 17 2004 2472 2477
36. I.G. Barrison, I.D. Knight, L. Viola, M.A. Boots, I.M. Murray-Lion, and T.R. Mitchell Platelet associated immunoglobulins on chronic liver disease Br J Haematol 48 2 1981 347 350 (Pubitemid 11054537)
37. G. Leone, A. Agostini, G. Mango, R. Landolfi, V.M. Valori, and B. Bizzi Megathrombocytes, platelet regeneration time and platelet associated IgG in idiopathic thrombocytopenic purpura and in thrombocytopenia associated with chronic liver disease Acta Haematol 65 1 1981 40 47 (Pubitemid 11145932)
38. D. Graber, D. Giuliani, C.M. Leevy, and B.S. Morse Platelet-associated IgG in hepatitis and cirrhosis J Clin Immunol 4 2 1984 108 111 (Pubitemid 14146847)
39. C. Mueller-Eckhardt, W. Kayser, K. Mersch-Baumert, G. Mueller-Eckhardt, M. Breidenbach, and H.G. Kugel The clinical significance of platelet-associated IgG: a study on 298 patients with various disorders Br J Haematol 46 1 1980 123 131 (Pubitemid 10009350)
40. J.G. Kelton, P.J. Powers, and C.J. Carter A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura Blood 60 4 1982 1050 1053 (Pubitemid 12001471)
41. D.B. Cines, and V.S. Blanchette Immune thrombocytopenic purpura N Engl J Med 346 13 2002 995 1008
42. M. Hürlimann-Forster, B. Steiner, and A. von Felten Quantitation of platelet-specific autoantibodies in platelet eluates of ITP patients measured by a novel ELISA using the purified glycoprotein complexes GPIIb/IIIa and GPIb/IX as antigens Br J Haematol 98 2 1997 328 335 (Pubitemid 27345106)
43. K. Fujisawa, T.E. O'Toole, P. Tani, J.C. Loftus, E.F. Plow, and M.H. Ginsberg Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura Blood 77 10 1991 2207 2213
44. B.H. Chong, and T.B. Keng Advances in the diagnosis of idiopathic thrombocytopenic purpura Semin Hematol 37 3 2000 249 260 (Pubitemid 30612903)
45. M. Kajihara, S. Kato, Y. Okazaki, Y. Kawakami, H. Ishii, and Y. Ikeda A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis Hepatology 37 6 2003 1267 1276 (Pubitemid 36667305)
46. B.D. Clifford, D. Donahue, L. Smith, E. Cable, B. Luttig, and M. Manns High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C Hepatology 21 3 1995 613 619
47. J.M. Pawlotsky, M. Ben Yahia, C. Andre, M.C. Voisin, L. Intrator, and F. Roudot-Thoraval Immunological disorders in C virus chronic active hepatitis: a prospective case-control study Hepatology 19 4 1994 841 848 (Pubitemid 24109343)
48. C. Mazzaro, V. Zagonel, S. Monfardini, S. Tulissi, E. Pussini, and E. Fanni-Canelles Hepatitis C virus and non-Hodgkin's lymphomas Br J Haematol 92 6 1996 1275 1279
49. B. Terrier, D. Sne, D. Saadoun, P. Ghillani-Dalbin, V. Thibault, and A. Delluc Serum free light chain assessment in hepatitis C virus-related lymphoproliferative disorders Ann Rheum Dis 68 1 2009 89 93
50. M. Fiorilli, C. Mecucci, P. Farci, and M. Casato HCV-associated lymphomas Rev Clin Exp Hematol 7 4 2003 406 423 (Pubitemid 38248513)
51. V. Agnello, R.T. Chung, and L.M. Kaplan A role for hepatitis C virus infection in type II cryoglobulinemia N Engl J Med 327 21 1992 1490 1495
52. G. Pozzato, C. Mazzaro, M. Crovatto, M.L. Modolo, S. Ceselli, and G. Mazzi Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia Blood 84 9 1994 3047 3053 (Pubitemid 24328097)
53. D. Rosa, G. Saletti, E. De Gregorio, F. Zorat, C. Comar, and U. D'Oro Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders Proc Natl Acad Sci USA 102 51 2005 18544 18549 (Pubitemid 43011262)
54. G. Pozzato, O. Burrone, K. Baba, M. Matsumoto, M. Hijiiata, and Y. Ota Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease J Hepatol 30 6 1999 990 994 (Pubitemid 29278741)
55. H.K. Law, S.J. Bol, M. Palatsides, and N.T. Williams Analysis of human megakaryocytic cells using dual-color immunofluorescence labeling Cytometry 41 4 2000 308 315
56. R. McMillan, L. Wang, A. Tomer, J. Nichol, and J. Pistillo Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP Blood 103 4 2004 1364 1369 (Pubitemid 38168649)
57. M. Chang, P.A. Nakagawa, S.A. Williams, M.R. Schwartz, K.L. Imfeld, and J.S. Buzby Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro Blood 102 3 2002 887 895 (Pubitemid 36917780)
58. J.B. Bussel, G. Cheng, M.N. Saleh, B. Psaila, L. Kovaleva, and B. Meddeb Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura N Engl J Med 357 22 2007 2237 2247 (Pubitemid 350190754)
59. R. Stasi, M.L. Evangelista, and S. Amadori Novel thrombopoietic agents: a review of their use in idiopathic thrombocytopenic purpura Drugs 68 7 2008 901 912 (Pubitemid 351652920)
60. J.G. McHutchison, G. Dusheiko, M.L. Shiffman, M. Rodriguez-Torres, S. Sigal, and M. Bourliere Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C N Engl J Med 357 22 2007 2227 2236 (Pubitemid 350190753)
61. B.B. Weksler The pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease Aliment Pharmacol Ther 26 Suppl. 1 2007 13 19 (Pubitemid 47631869)