Loss of E2F7 expression is an early event in squamous differentiation and causes derepression of the key differentiation activator sp1

Journal of Investigative Dermatology

Volumn 131, Issue 5, 2011, Pages 1077-1084

  Hazar Rethinam, Mehlika ^a   Cameron, Sarina R ^a   Dahler, Alison L ^a   Endo Munoz, Liliana B ^a   Smith, Louise ^a   Rickwood, Danny ^a   Saunders, Nicholas A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INVOLUCRIN; ISOPROTEIN; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 1; TRANSCRIPTION FACTOR E2F7; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIFFERENTIATION; ENZYME INDUCTION; FEMALE; GENE LOSS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS DIFFERENTIATION; WESTERN BLOTTING;

EID: 79954847218     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.430     Document Type: Article

References (39)

1. Apt D, Watts RM, Suske G et al. (1996) High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter. Virology 224:281-91 (Pubitemid 26358124)
2. Araki K, Nakajima Y, Eto K et al. (2003) Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression ofthe E2F1 promoter. Oncogene 22:7632-41 (Pubitemid 37464097)
3. Banks EB, Crish JF, Welter JF et al. (1998) Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites. Biochem J 331:61-8 (Pubitemid 28163957)
4. Brinkmann H, Dahler AL, Popa C et al. (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J Biol Chem 276: 22491-9
5. Chen TT, Wu RL, Castro-Munozledo F et al. (1997) Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells. Mol Cell Biol 17:3056-64 (Pubitemid 27215020)
6. Crish JF, Eckert RL (2008) Synergistic activation of human involucrin gene expression by Fra-1 and p300-evidence for the presence of a multi-protein complex. J Invest Dermatol 128:530-41 (Pubitemid 351252656)
7. Dahler AL, Jones SJ, Dicker AJ et al. (1998) Keratinocyte growth arrest is associated with activation of a transcriptional repressor element in the human cdk1 promoter. J Cell Physiol 177:474-82 (Pubitemid 28524670)
8. de Bruin A, Maiti B, Jakoi L et al. (2003) Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 278:42041-9 (Pubitemid 37310469)
9. DeGregori J, Johnson DG (2006) Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6:739-48 (Pubitemid 44725567)
10. Dicker AJ, Popa C, Dahler AL et al. (2000) E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes. Oncogene 19:2887-94 (Pubitemid 30389078)
11. Di Stefano L, Jensen MR, Helin K (2003) E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 22:6289-98 (Pubitemid 37522586)
12. Eckert RL, Crish JF, Banks EB et al. (1997) The epidermis: genes on-genes off. J Invest Dermatol 109:501-9
13. Eckert RL, Crish JF, Robinson NA (1998) The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77:397-424
14. Endo-Munoz L, Dahler AL, Teakle N et al. (2009) E2F7 can regulate proliferation, differentiation, and apoptotic responses in human kerati-nocytes: implications for cutaneous squamous cell carcinoma formation. Cancer Res 69:1800-8
15. Jang SI, Steinert PM (2002) Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families. J Biol Chem 277:42268-79 (Pubitemid 35257547)
16. Johnson DG, DeGregori J (2006) Putting the oncogenic and tumor suppressive activities of E2F into context. Curr Mol Med 6:731-8 (Pubitemid 44725566)
17. Jones SJ, Dicker AJ, Dahler AL et al. (1997) E2F as a regulator of keratinocyte proliferation: implications for skin tumor development. J Invest Dermatol 109:187-93 (Pubitemid 27337334)
18. Kel AE, Kel-Margouli OV, Farnham PJ et al. (2001) Computer-assisted identification of cell cycle-related genes: new targets for E2F transcrip-tion factors. J Mol Biol 309:99-120 (Pubitemid 32553511)
19. Lania L, Majello B, DeLuca P (1997) Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 29:1313-23 (Pubitemid 28153485)
20. Lee JH, Jang SI, Yang JM et al. (1996) The proximal promoter of the human transglutaminase 3 gene. Stratified squamous epithelial-specific expression in cultured cells is mediated by binding of Sp1 and Ets transcription factors to a proximal promoter element. J Biol Chem 271:4561-8
21. Li J, Ran C, Li E et al. (2008) Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell 14:62-75
22. Medvedev A, Saunders NA, Chistokhina A et al. (1999) Regulation of the transglutaminase I gene. Identification of DNA elements involved in its transcriptional control in tracheobronchial epithelial cells. J Biol Chem 274:3887-96 (Pubitemid 29077239)
23. Muller H, Bracken AP, Vernell R et al. (2001) E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev 15:267-85 (Pubitemid 32155143)
24. Nicolas M, Noe V, Ciudad CJ (2003) Transcriptional regulation of the human Sp1 gene promoter by the specificity protein (Sp) family members nuclear factor Y (NF-Y) and E2F. Biochem J 371:265-75 (Pubitemid 36547609)
25. Nicolas M, Noe V, Jensen KB et al. (2001) Cloningand characterization ofthe 5'-flanking region of the human transcription factor Sp1 gene. J Biol Chem 276:22126-32
26. Paramio JM, Segrelles C, Casanova ML et al. (2000) Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation. J Biol Chem 275:41219-26 (Pubitemid 32054954)
27. Park GT, Morasso MI (1999) Regulation of the Dlx3 homeobox gene upon differentiation of mouse keratinocytes. J Biol Chem 274:3887-96
28. Phillips MA, Jessen BA, Lu Y et al. (2004) A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes. BMC Dermatol 4:2
29. Pierce AM, Schneider-Broussard R, Gimenez-Conti IB et al. (1999) E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model. Mol Cell Biol 19:6408-14 (Pubitemid 29399344)
30. Popa C, Dahler AL, Serewko-Auret MM et al. (2004) AP-2 transcription factor family member expression, activity, and regulation in human epidermal keratinocytes in vitro. Differentiation 72:185-97 (Pubitemid 41702128)
31. Sen GL, Webster DE, Barragan DI et al. (2009) Control ofdifferentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev 22:1865-70 (Pubitemid 352008635)
32. Serewko MM, Popa C, Dahler AL et al. (2002) Alterations in gene expression and activity during squamous cell carcinoma development. Cancer Res 62:3759-65 (Pubitemid 34728858)
33. Smith L, Dahler AL, Popa C et al. (2004) Modulation of proliferation-specific and differentiation-specific markers in human keratinocytes by SMAD7. Exp Cell Res 294:356-65 (Pubitemid 38331978)
34. Walshe J, Serewko-Auret MM, Teakle N et al. (2007) Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation. Cancer Res 67:4751-8 (Pubitemid 46910182)
35. Wong CF, Barnes LM, Dahler AL et al. (2003) E2F modulates keratinocyte squamous differentiation: implications for E2F inhibition in squamous cell carcinoma. J Biol Chem 278:28516-22 (Pubitemid 36935754)
36. Wong CF, Barnes LM, Dahler AL et al. (2005) E2F suppression and Sp1 overexpression are sufficient to induce the differentiation-specific marker, transglutaminase type 1, in a squamous cell carcinoma cell line. Oncogene 24:3525-34 (Pubitemid 40756253)
37. Wong CF, Barnes LM, Smith L et al. (2004) E2F6: a member of the E2F family that does not modulate squamous differentiation. Biochem Biophys Res Commum 324:497-503 (Pubitemid 39345545)
38. Wu RL, Chen TT, Sun TT (1994) Functional importance of an Sp1-and an NFkB-related nuclear protein in a keratinocyte-specific promoter of rabbit K3 keratin gene. J Biol Chem 269:28450-9
39. Zalmas LP, Zhao X, Graham AL et al. (2008) DNA-damage response control of E2F7 and E2F8. EMBO Rep 9:252-9 (Pubitemid 351330990)