Biological evaluation of penetration domain and killing domain peptides

Journal of Gene Medicine

Volumn 7, Issue 7, 2005, Pages 908-917

  Jarajapu, Y P R ^b   Baltunis, J ^a   Knot, H J ^a,b   Sullivan, S M ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Alternative reading frame (ARF); Antennaepedia homeodomain; Cell killing; Endothelial cells; Glioblastoma cells; HIV Tat; P14; Peptide

Indexed keywords

ANTENNAPEDIA PROTEIN; FLUORESCENT DYE; PROPIDIUM IODIDE; PROTEIN MDM2; PROTEIN P14ARF; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN ARTERY; BYSTANDER EFFECT; CANCER CELL CULTURE; CANCER GENETICS; CARBOXY TERMINAL SEQUENCE; CELL KILLING; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DROSOPHILA; DRUG EFFICACY; ENDOTHELIUM CELL; FLUORESCENCE ACTIVATED CELL SORTING; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GLIOBLASTOMA; GLIOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION KINETICS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RAT; SMOOTH MUSCLE FIBER; TUMOR CELL; VASODILATATION;

AMINO ACID SEQUENCE; ANIMALS; ANTENNAPEDIA HOMEODOMAIN PROTEIN; BIOLOGICAL TRANSPORT; BRAIN; BRAIN NEOPLASMS; CELL DEATH; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GENE PRODUCTS, TAT; GENE THERAPY; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 22544478853     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.738     Document Type: Article

References (29)

1. Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988; 55: 1189-1193.
2. Chen LL, Frankel AD, Harder JL, Fawell S, Barsoum J, Pepinsky B. Increased cellular uptake of the human immunodeficiency virus-1 Tat protein after modification with biotin. Anal Biochem 1995; 227: 168-175.
3. Astriab-Fisher A, Sergueev D, Fisher M, Shaw BR, Juliano RL. Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. Pharm Res 2002; 19: 744-754.
4. Prochiantz A. Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol 2000; 12: 400-406.
5. Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 1998; 16: 440-443.
6. Hawiger J. Cellular import of functional peptides to block intracellular signaling. Curr Opin Immunol 1997; 9: 189-194.
7. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285: 1569-1572.
8. Fischer R, Kohler K, Fotin-Mleczek M, Brock R. A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides. J Biol Chem 2004; 279: 12 625-12 635.
9. Snyder EL, Meade BR, Dowdy SF. Anti-cancer protein transduction strategies: reconstitution of p27 tumor suppressor function. J Control Release 2003; 91: 45-51.
10. Snyder EL, Meade BR, Saenz CC, Dowdy SF. Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. PLoS Biol 2004; 2: E36.
11. Niesner U, Halin C, Lozzi L, et al. Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjugate Chem 2002; 13: 729-736.
12. Torchilin VP, Levchenko TS, Rammohan R, Volodina N, Papahadjopoulos-Sternberg B, D'Souza GG. Cell transduction in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc Natl Acad Sci U S A 2003; 100: 1972-1977.
13. Ignatovich IA, Dizhe EB, Pavlotskaya AV, et al. Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways. J Biol Chem 2003; 278: 42 625-42 636.
14. Deb SP. Cell cycle regulatory functions of the human oncoprotein MDM2. Mol Cancer Res 2003; 1: 1009-1016.
15. Giard DJ, Aaronson SA, Todaro GJ, et al. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 1973; 51: 1417-1423.
16. Stein GH. T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J Cell Physiol 1979; 99: 43-54.
17. Barth RF. Rat brain tumor models in experimental neurooncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas. J Neurooncol 1998; 36: 91-102.
18. Knot HJ, Nelson MT. Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol 1998; 508(Pt 1): 199-209.
19. Mi Z, Mai J, Lu X, Robbins PD. Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo. Mol Ther 2000; 2: 339-347.
20. Ferrari A, Pellegrini V, Arcangeli C, Fittipaldi A, Giacca M, Beltram F. Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. Mol Ther 2003; 8: 284-294.
21. Moede T, Leibiger B, Pour HG, Berggren P, Leibiger IB. Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1. FEBS Lett 1999; 461: 229-234.
22. Efthymiadis A, Briggs LJ, Jans DA. The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties. J Biol Chem 1998; 273: 1623-1628.
23. Rizos H, Darmanian AP, Mann GJ, Kefford RF. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene 2000; 19: 2978-2985.
24. Frum R, Deb SP. Flow cytometric analysis of MDM2-mediated growth arrest. Methods Mol Biol 2003; 234: 257-267.
25. Deb SP. Function and dysfunction of the human oncoprotein MDM2. Front Biosci 2002; 7: d235-243.
26. Clark PA, Llanos S, Peters G. Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2. Oncogene 2002; 21: 4498-4507.
27. Eymin B, Leduc C, Coll JL, Brambilla E, Gazzeri S. p14ARF induces G2 arrest and apoprosis independently of p53 leading to regression of tumours established in nude mice. Oncogene 2003; 22: 1822-1835.
28. Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol 2000; 10: 290-295.
29. Florell SR, Meyer LJ, Boucher KM, et al. Longitudinal assessment of the nevus phenotype in a melanoma kindred. J Invest Dermatol 2004; 123: 576-582.