Structure and metal ion binding of the first transmembrane domain of DMT1

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 6, 2011, Pages 1639-1644

  Wang, Dan ^a   Song, Yuande ^a   Li, Jiantao ^a   Wang, Chunyu ^a   Li, Fei ^a  

^a Jilin University   (China)

Author keywords

DMT1 TMD1; Metal ion binding; NMR; Structure; Topology

Indexed keywords

COBALT; DODECYL SULFATE SODIUM; DODECYLPHOSPHORYLCHOLINE; MANGANESE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATION TRANSPORT PROTEINS; COBALT; HUMANS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MANGANESE; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLCHOLINE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SODIUM DODECYL SULFATE;

EID: 79954639335     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.11.005     Document Type: Article

References (31)

1. D.R. Richardson, and P. Ponka The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells Biochim. Biophys. Acta 1331 1997 1 40 (Pubitemid 27168147)
2. Z.M. Qian, Q. Wang, and P.L. Tang Iron crossed the endosomal membrane by a carrier-mediated process Prog. Biophys. Mol. Biol. 67 1997 1 15 (Pubitemid 27491747)
3. E.C. Hirsch Biochemistry of Parkinson's disease with special reference to the dopaminergic systems Mol. Neurobiol. 9 1994 135 142
4. N.C. Andrews Disorders of iron metabolism New Engl. J. Med. 341 1999 1986 1995 (Pubitemid 30010408)
5. S. Gruenheid, M. Cellier, S. Vidal, and P. Gros Identification and characterization of a second mouse Nramp gene Genomics 25 1995 514 525
6. S. Vidal, D. Malo, K. Vogan, E. Skamene, and P. Gros Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg Cell 73 1993 469 485 (Pubitemid 23143347)
7. S. Vidal, P. Gros, and E. Skamene Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus J. Leuk. Biol. 58 1995 382 390
8. F. Canonne-Hergaux, S. Gruenheid, P. Ponka, and P. Gros Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron Blood 93 1999 4406 4417 (Pubitemid 29279284)
9. M.D. Fleming, C.C. Trenor III, M.A. Su, D. Foernzler, D.R. Beier, W.F. Dietrich, and N.C. Andrews Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene Nat. Genet. l6 1997 383 386 (Pubitemid 27323306)
10. H. Gunshin, B. Mackenzie, U.V. Berger, Y. Gunshin, M.F. Romero, W.F. Boron, S. Nussberger, J.L. Gollan, and M.A. Hediger Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 1997 482 488 (Pubitemid 27328927)
11. D169) mouse strains J. Immunol. 157 1996 3559 3568 (Pubitemid 126449170)
12. M. Czachorowski, S. Lam-Yuk-Tseung, M. Cellier, and P. Gros Transmembrane topology of the mammalian Slc11a2 iron transporter Biochemistry 48 2009 8422 8434
13. M. Cellier, G. Prive, A. Belouchi, T. Kwan, V. Rodrigues, W. Chia, and P. Gros Nramp defines a family of membrane proteins Proc. Natl. Acad. Sci. U. S. A. 92 1995 10089 10093
14. H.A.H. Haemig, and R.J. Brooker Importance of conserved acidic residues in MntH, the Nramp homolog of Escherichia coli J. Membr. Biol. 201 2004 97 107
15. S. Lam-Yuk-Tseung, G. Govoni, J. Forbes, and P. Gros Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6 Blood 101 2003 3699 3707 (Pubitemid 36857962)
16. A. Cohen, Y. Nevo, and N. Nelson The first external loop of the metal-ion transporter DCT1 is involved in metal-ion binding and specificity Proc. Natl. Acad. Sci. U. S. A. 100 2003 10694 10699 (Pubitemid 37140090)
17. Y. Song, D. Wang, H. Qi, S. Xiao, R. Xue, and F. Li Metal ion binding of the first external loop of DCT1 in aqueous solution Metallomics 1 2009 392 394
18. P. Courville, E. Urbankova, C. Rensing, R. Chaloupka, M. Quick, and M.F. Cellier Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6 J. Biol. Chem. 283 2008 9651 9658
19. A. Bax, and D.G. Davis MLEV-17-based two-dimensional homo-nuclear magnetization transfer spectroscopy J. Magn. Reson. 65 1985 355 360
20. M. Piotto, V. Saudek, and V. Sklenar Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions J. Biol. NMR 2 1992 661 665
21. 15N HSQC experiments optimized to retain full sensitivity J. Magn. Reson. 102 1993 241 245
22. T.D. Goddard, and D.G. Kneller 2001 University of California San Francisco
23. P. Güntert, C. Mumenthaler, and K. Wüthrich Torsion angle dynamics for NMR structure calculation with the new program DYANA J. Mol. Biol. 273 1997 283 298 (Pubitemid 27460230)
24. D.A. Pearlman, D.A. Case, J.W. Caldwell, W.S. Ross, T.E. Cheatham III, S. DeBolt, D. Ferguson, G. Seibel, and P. Kollman AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules Comput. Phys. Commun. 91 1995 1 41
25. W.D. Cornell, P. Cieplak, C.I. Bayly, I.R. Gould, K.M. Merz, D.M. Ferguson, D.C. Spellmeyer, T. Fox, J.W. Caldwell, and P.A. Kollman A second generation force field for the simulation of proteins, nucleic acids, and organic molecules J. Am. Chem. Soc. 117 1995 5179 5197
26. R.A. Laskowski, J.A. Rullmann, M.W. MacArthur, R. Kaptein, and J.M. Thornton AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR J. Biomol. NMR 8 1996 477 486 (Pubitemid 126706801)
27. R. Koradi, M. Billeter, and K. Wüthrich MOLMOL: a program for display and analysis of macromolecular structures J. Mol. Graph. 14 1996 51 55 (Pubitemid 26152976)
28. M. Bisaglia, I. Tessari, L. Pinato, M. Bellanda, S. Giraudo, M. Fasano, E. Bergantino, L. Bubacco, and S. Mammi A topological model of the interaction between α-synuclein and sodium dodecyl sulfate micelles Biochemistry 44 2005 329 339 (Pubitemid 40095735)
29. M. Lindberg, J. Jarvet, U. Langel, and A. Graslund Secondary structure and position of the cell-penetrating peptide transportan in SDS micelles as determined by NMR Biochemistry 40 2001 3141 3149 (Pubitemid 32205358)
30. S. Xiao, J. Li, Y. Wang, C. Wang, R. Xue, S. Wang, and F. Li Identification of an "α-helix-extended segment-α-helix" conformation of the sixth transmembrane domain in DMT1 Biochim. Biophys. Acta 1798 2010 1556 1564
31. R. Chaloupka, P. Courville, F. Veyrier, B. Knudsen, T.A. Tompkins, and M.F. Cellier Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton co-transport in vivo Biochemistry 44 2005 726 733 (Pubitemid 40105504)