Hybrid training of voluntary and electrical muscle contractions decreased fasting blood glucose and serum interleukin-6 levels in elderly people: A pilot study

Applied Physiology, Nutrition and Metabolism

Volumn 36, Issue 2, 2011, Pages 276-282

  Kawaguchi, Takumi ^a   Shiba, Naoto ^b   Takano, Yoshio ^c   Maeda, Takashi ^b   Sata, Michio ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY HOSPITAL   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Advanced age; Cytokine; Exercise; Glucose metabolism; Muscle

Indexed keywords

INTERLEUKIN 6;

AGED; AGING; ARTICLE; BLOOD; DIET RESTRICTION; ELECTROSTIMULATION THERAPY; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; KINESIOTHERAPY; MALE; METABOLISM; METHODOLOGY; MUSCLE CONTRACTION; MUSCLE ISOMETRIC CONTRACTION; PHYSIOLOGY; PILOT STUDY; SKELETAL MUSCLE;

AGED; AGING; BLOOD GLUCOSE; ELECTRIC STIMULATION THERAPY; EXERCISE; EXERCISE THERAPY; FASTING; FEMALE; HUMANS; INTERLEUKIN-6; ISOMETRIC CONTRACTION; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PILOT PROJECTS;

EID: 79954627101     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/h10-108     Document Type: Article

References (42)

1. Borst, S.E. 2004. The role of TNF-α in insulin resistance. Endocrine, 23 (2-3): 177-182. doi:10.1385/ENDO:23:2-3:177. PMID:15146098.
2. Chiarugi, P., and Fiaschi, T. 2010. Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration. Expert Opin. Ther. Targets, 14(2): 193-206. doi:10.1517/14728220903530712. PMID:20017651.
3. Chilibeck, P.D., Bell, G., Jeon, J., Weiss, C.B., Murdoch, G., MacLean, I., et al. 1999a. Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle. Metabolism, 48(11): 1409-1413. doi:10.1016/S0026-0495(99)90151-8. PMID:10582549.
4. Chilibeck, P.D., Jeon, J., Weiss, C., Bell, G., and Burnham, R. 1999b. Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training. Spinal Cord, 37(4): 264-268. doi:10.1038/sj.sc.3100785. PMID:10338346.
5. Crotty, M., Unroe, K., Cameron, I.D., Miller, M., Ramirez, G., and Couzner, L. 2010. Rehabilitation interventions for improving physical and psychosocial functioning after hip fracture in older people. Cochrane Database Syst. Rev. (1): CD007624. doi:10. 1002/14651858.CD007624.pub3. PMID:20091644.
6. Erol, A. 2007. Interleukin-6 (IL-6) is still the leading biomarker of the metabolic and aging related disorders. Med. Hypotheses, 69(3): 708. doi:10.1016/j.mehy.2007.01.021. PMID:17335991.
7. Faulkner, J.A., Larkin, L.M., Claflin, D.R., and Brooks, S.V. 2007. Age-related changes in the structure and function of skeletal muscles. Clin. Exp. Pharmacol. Physiol. 34(11): 1091-1096. doi:10.1111/j.1440-1681.2007.04752.x. PMID:17880359.
8. Fève, B., and Bastard, J.P. 2009. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 5(6): 305-311. doi:10.1038/nrendo.2009.62. PMID:19399017.
9. Gray, S.R., Ratkevicius, A., Wackerhage, H., Coats, P., and Nimmo, M.A. 2009. The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle. Exp. Physiol. 94(8): 899-905. doi:10.1113/expphysiol.2009.048173. PMID:19482899.
10. Gregory, C.M., and Bickel, C.S. 2005. Recruitment patterns in human skeletal muscle during electrical stimulation. Phys. Ther. 85(4): 358-364. PMID:15794706.
11. Halseth, A.E., Bracy, D.P., and Wasserman, D.H. 2001. Functional limitations to glucose uptake in muscles comprised of different fiber types. Am. J. Physiol. Endocrinol. Metab. 280(6): E994-E999. PMID:11350781.
12. Heliövaara, M.K., Teppo, A.M., Karonen, S.L., Tuominen, J.A., and Ebeling, P. 2005. Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute-phase proteins associate with glucose and lipid metabolism in healthy subjects. Diabetes Obes. Metab. 7(6): 729-736. doi:10.1111/j.1463-1326.2004.00463.x. PMID: 16219017.
13. Henneman, E., Somjen, G., and Carpenter, D.O. 1965. Functional significance of cell size in spinal motoneurons. J. Neurophysiol. 28: 560-580. PMID:14328454.
14. Iwasaki, T., Shiba, N., Matsuse, H., Nago, T., Umezu, Y., Tagawa, Y., et al. 2006. Improvement in knee extension strength through training by means of combined electrical stimulation and voluntary muscle contraction. Tohoku J. Exp. Med. 209(1): 33-40. doi:10.1620/tjem.209.33. PMID:16636520.
15. Janssen, I., Heymsfield, S.B., Wang, Z.M., and Ross, R. 2000. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J. Appl. Physiol. 89(1): 81-88. PMID:10904038.
16. Jové, M., Planavila, A., Laguna, J.C., and Vazquez-Carrera, M. 2005. Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells. Endocrinology, 146(7): 3087-3095. doi:10.1210/en.2004-1560. PMID:15802498.
17. Kawaguchi, T., Yoshida, T., Harada, M., Hisamoto, T., Nagao, Y., Ide, T., et al. 2004. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. Am. J. Pathol. 165(5): 1499-1508. doi:165/ 5/1499. PMID:15509521.
18. Klip, A., and Paquet, M.R. 1990. Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care, 13(3): 228-243. doi:10.2337/diacare.13.3.228. PMID:2407478.
19. Latham, N.K., Bennett, D.A., Stretton, C.M., and Anderson, C.S. 2004. Systematic review of progressive resistance strength training in older adults. J. Gerontol. A Biol. Sci. Med. Sci. 59(1): 48-61. PMID:14718486.
20. Lexell, J. 1995. Human aging, muscle mass, and fiber type composition. J. Gerontol. A Biol. Sci. Med. Sci. 50(Spec No): 11-16. PMID:7493202.
21. Lexell, J., Taylor, C.C., and Sjostrom, M. 1988. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J. Neurol. Sci. 84(2-3): 275-294. doi:10.1016/0022-510X(88)90132-3. PMID:3379447.
22. Lihn, A.S., Pedersen, S.B., Lund, S., and Richelsen, B. 2008. The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells. Mol. Cell. Endocrinol. 292(1-2): 36-41. doi:10.1016/j.mce.2008.06.004. PMID:18606210.
23. Macheda, M.L., Rogers, S., and Best, J.D. 2005. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J. Cell. Physiol. 202(3): 654-662. doi:10.1002/jcp.20166.PMID:15389572.
24. Marra, F., and Bertolani, C. 2009. Adipokines in liver diseases. Hepatology, 50(3): 957-969. doi:10.1002/hep.23046. PMID: 19585655.
25. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., and Turner, R.C. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7): 412-419. doi:10.1007/BF00280883. PMID:3899825.
26. Mazzeo, R.S., and Tanaka, H. 2001. Exercise prescription for the elderly: current recommendations. Sports Med. 31(11): 809-818. doi:10.2165/00007256-200131110-00003. PMID:11583105.
27. Menzaghi, C., Trischitta, V., and Doria, A. 2007. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes, 56(5): 1198-1209. doi:10.2337/db06-0506. PMID:17303804.
28. Meuleman, J.R., Brechue, W.F., Kubilis, P.S., and Lowenthal, D.T. 2000. Exercise training in the debilitated aged: strength and functional outcomes. Arch. Phys. Med. Rehabil. 81(3): 312-318. doi:S0003-9993(00)90077-7. PMID:10724076.
29. Nago, T., Umezu, Y., Shiba, N., Matsuse, H., Maeda, T., Tagawa, Y., et al. 2007. Muscle maintenance by volitional contraction against applied electrical stimulation. Kurume Med. J. 54(1/2): 35-40. doi:10.2739/kurumemedj.54.35. PMID:18332595.
30. Nieto-Vazquez, I., Fernandez-Veledo, S., de Alvaro, C., and Lorenzo, M. 2008. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes, 57(12): 3211-3221. doi:10. 2337/db07-1062. PMID:18796617.
31. Park, S.W., Goodpaster, B.H., Strotmeyer, E.S., Kuller, L.H., Broudeau, R., Kammerer, C., et al. 2007. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. The Health, Aging, and Body Composition Study. Diabetes Care, 30(6): 1507-1512. doi:10.2337/dc06-2537. PMID:17363749.
32. Pedersen, B.K. 2006. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem. 42(1): 105-117. doi:10.1042/bse0420105. PMID:17144883.
33. Pedersen, B.K., and Febbraio, M.A. 2008. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 88(4): 1379-1406. doi:10.1152/physrev.90100.2007. PMID:18923185.
34. Rydwik, E., Gustafsson, T., Frandin, K., and Akner, G. 2010. Effects of physical training on aerobic capacity in frail elderly people (75+ years). Influence of lung capacity, cardiovascular disease and medical drug treatment: a randomized controlled pilot trial. Aging Clin. Exp. Res. 22(1): 85-94. PMID:20305369.
35. Steensberg, A. 2003. The role of IL-6 in exercise-induced immune changes and metabolism. Exerc. Immunol. Rev. 9: 40-47. PMID:14686093.
36. Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., and Pedersen, B.K. 2000. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J. Physiol. 529(1): 237-242. doi:10.1111/j.1469-7793.2000.00237.x. PMID:11080265.
37. Stefanyk, L.E., and Dyck, D.J. 2010. The interaction between adipokines, diet and exercise on muscle insulin sensitivity. Curr. Opin. Clin. Nutr. Metab. Care, 13(3): 255-259. doi:10.1097/MCO.0b013e328338236e. PMID:20216410.
38. Takano, Y., Haneda, Y., Maeda, T., Sakai, Y., Matsuse, H., Kawaguchi, T., et al. 2010. Increasing muscle strength and mass of thigh in elderly people with the hybrid-training method of electrical stimulation and volitional contraction. Tohoku J. Exp. Med. 221(1): 77-85. doi:10.1620/tjem.221.77. PMID:20453461.
39. Tinetti, M.E., Speechley, M., and Ginter, S.F. 1988. Risk factors for falls among elderly persons living in the community. N. Engl. J. Med. 319(26): 1701-1707. doi:10.1056/NEJM198812293192604. PMID:3205267.
40. Yanagi, T., Shiba, N., Maeda, T., Iwasa, K., Umezu, Y., Tagawa, Y., et al. 2003. Agonist contractions against electrically stimulated antagonists. Arch. Phys. Med. Rehabil. 84(6): 843-848. doi:10. 1016/S0003-9993(02)04948-1. PMID:12808536.
41. Yang, B., Chen, L., Qian, Y., Triantafillou, J.A., McNulty, J.A., Carrick, K., et al. 2006. Changes of skeletalmuscle adiponectin content in dietinduced insulin resistant rats. Biochem. Biophys. Res. Commun. 341 (1): 209-217. doi:10.1016/j.bbrc.2005.12.172. PMID:16414018.
42. Yoshimitsu, K., Shiba, N., Matsuse, H., Takano, Y., Matsugaki, T., Inada, T., et al. 2010. Development of a training method for weightless environment using both electrical stimulation and voluntary muscle contraction. Tohoku J. Exp. Med. 220(1): 83-93. doi:10.1620/tjem.220.83. PMID:20046056.