Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma

Journal of Oral Pathology and Medicine

Volumn 40, Issue 5, 2011, Pages 380-384

  Costa, Nádia Lago ^a   Gonçalves, Andréia Souza ^a   Souza Lima, Nathália Caroline ^a   Jaime Paiva, Luís Gustavo ^a   Junqueira Kipnis, Ana Paula ^a   Silva, Tarcília Aparecida ^b   Mendonça, Elismauro Francisco ^a,c   Batista, Aline Carvalho ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c Association to Combat Cancer in Goiás Hospital Araújo Jorge   (Brazil)

Author keywords

Granzyme B; Lip squamous cell carcinoma; Oral squamous cell carcinoma; Perforin

Indexed keywords

CD8 ANTIGEN; GRANZYME B; PERFORIN;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CHEILITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; LICHEN PLANUS; LIP CARCINOMA; MALE; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CHEILITIS; FEMALE; GRANZYMES; HUMANS; LEUKOPLAKIA, ORAL; LICHEN PLANUS, ORAL; LIP NEOPLASMS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MOUTH FLOOR; MOUTH MUCOSA; MOUTH NEOPLASMS; PERFORIN; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 79954623259     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2011.01014.x     Document Type: Article

References (16)

1. Abbas AK, Lichtman AH, Shiv P. Immunity to tumors. In: Abbas AK, Lichtman AH, Shiv P eds. Cellular and molecular immunology. Philadelphia: Saunders, 2008; 397-417.
2. Afonina IS, Cullen SP, Martin SJ. Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. Immunol Rev 2010; 235: 105-16.
3. Anthony DA, Andrews DM, Watt SV, Trapani JA, Smyth MJ. Functional dissection of the granzyme family: cell death and inflammation. Immunol Rev 2010; 235: 73-92.
4. Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA. Perforin: structure, function, and role in human immunopathology. Immunol Rev 2010; 235: 35-54.
5. Costa NL, Alencar RCG, Valadares MC, Silva TA, Mendonça EF, Batista AC. The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma. Oral Oncol 2010; 46: 185-9.
6. Zancope E, Costa NL, Junqueira-Kipnis AP, et al. Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinoma. J Oral Pathol Med 2010; 39: 162-7.
7. Brennan AJ, Chia J, Trapani JA, Voskoboinik I. Perforin deficiency and susceptibility to cancer. Cell Death Differ 2010; 17: 607-15.
8. Cullen SP, Brunet M, Martin SJ. Granzymes in cancer and immunity. Cell Death Differ 2010; 17: 616-23.
9. Kondo MC, Ribalta JC, Da Silva ID, et al. Granzyme B as a prognostic marker of cervical intraepithelial neoplasia. Eur J Gynaecol Oncol 2005; 26: 87-9.
10. Batinac T, Zamolo G, Hadzisejdic I, Zauhar G. A comparative study of Granzyme B expression in keratoacanthoma and squamous cell carcinoma. J Dermatol Sci 2006; 44: 109-12.
11. Van Houdt IS, Sluijter BJR, Moesbergen LM, et al. Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression. Int J Cancer 2008; 123: 609-15.
12. Batista AC, Costa NL, Oton-Leite AF, Mendonça EF, Alencar RCG, Silva TA. Distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e74-9.
13. Leite IC, Koifman S. Survival analysis in a sample of oral cancer patients at a reference hospital in Rio de Janeiro, Brazil. Oral Oncol 1998; 34: 347-52.
14. Vartanian JG, Carvalho AL, De Araujo Filho MJ, Junior MH, Magrin J, Kowalski LP. Predictive factors and distribution of lymph node metastasis in lip cancer patients and their implications on the treatment of the neck. Oral Oncol 2004; 40: 223-7.
15. Cruz I, Meijer CJ, Walboomers JM, Snijders PJ, Van Der Waal I. Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinoma. Br J Cancer 1999; 81: 881-9.
16. Katou F, Ohtani H, Watanabe Y, Nakayama T, Yoshie O, Hashimoto K. Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer. Cancer Res 2007; 67: 11195-201.