A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma

Journal of Dermatological Science

Volumn 44, Issue 2, 2006, Pages 109-112

  Batinac, Tanja ^a   Zamolo, Gordana ^b   Hadzisejdic, Ita ^b   Zauhar, Gordana ^c  

^a KBC RIJEKA   (Croatia)

^b UNIVERSITY OF RIJEKA   (Croatia)

^c University of Rijeka Radmile   (Croatia)

Author keywords

Granzyme B; Keratoacanthoma; Squamous cell carcinoma

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DEATH RECEPTOR; GRANZYME B;

ADULT; AGED; CANCER GROWTH; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DENSITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; KERATOACANTHOMA; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TUMOR CELL; TUMOR LOCALIZATION;

AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANZYMES; HUMANS; KERATOACANTHOMA; MALE; MIDDLE AGED; SKIN DISEASES; SKIN NEOPLASMS; T-LYMPHOCYTES;

EID: 33749347696     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2006.07.003     Document Type: Letter

References (10)

1. Baham A., Regauer S., Soyer H.P., and Beham-Schmid C. Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma. Adv Anat Pathol 5 (1998) 269-280
2. Matsui S., Ahlers J.D., Vortmeyer A.O., Terabe M., Tsukui T., Carbone D.P., et al. A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4+ cells through an effect on Quality of CTL. J Immunol 163 (1999) 184-193
3. Pardo J., Bosque A., Brehm R., Wallich R., Naval J., Mullbacher A., et al. Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis. J Cell Biol 167 (2004) 457-468
4. Batinac T., Zamolo G., Coklo M., Hadzisejdic I., Stemberger C., and Zauhar G. Expression of cell cycle and apoptosis regulatory proteins in keratoacanthoma and squamous cell carcinoma. Pathol Res Pract 202 (2006) 599-607
5. Nakano O., Sato M., Naito Y., Suzuki K., Orikasa S., Aizawa M., et al. Proliferative activity of intratumoral CD8+ T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumour immunity. Cancer Res 61 (2001) 5132-5136
6. Grossman W.J., Verbsky J.W., Tollefsen B.L., Kemper C., Atkinson J.P., and Ley T.J. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104 (2004) 2840-2848
7. Smith K.J., Hamza S., and Skelton H. Topical imidazoquinoline therapy of cutaneous squamous cell carcinoma polarizes lymphoid and monocyte/macrophage populations to a Th1 and M1 cytokine pattern. Clin Exp Dermatol 29 (2004) 505-512
8. Reichert T.E., Strauss L., Wagner E.M., Gooding W., and Whiteside T.L. Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumour-infiltrating lymphocytes in patients with oral carcinoma. Clin Cancer Res 8 (2002) 3137-3145
9. Gastman B.R., Atarashi Y., Reichert T.E., Saito T., Balkir L., Rabinowich H., et al. Fas ligand is expressed on human squamous cell carcinomas of head and neck and it promotes apoptosis of T lymphocytes. Cancer Res 59 (1999) 5356-5364
10. Kuss I., Hathaway B., Ferris R.L., Gooding W., and Whiteside T.L. Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck. Clin Cancer Res 10 (2004) 3755-3762