Molecular basis of elansolid biosynthesis: Evidence for an unprecedented quinone methide initiated intramolecular diels-alder cycloaddition/ macrolactonization

Angewandte Chemie - International Edition

Volumn 50, Issue 17, 2011, Pages 3882-3887

  Dehn, Richard ^a   Katsuyama, Yohei ^b   Weber, Arne ^a   Gerth, Klaus ^b   Jansen, Rolf ^b   Steinmetz, Heinrich ^b   Höfle, Gerhard ^b   Müller, Rolf ^b   Kirschning, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

biosynthesis; intramolecular Diels Alder reaction; macrocyclizations; polyketides; quinone methides

Indexed keywords

BIOSYNTHETIC GENE CLUSTER; DEHYDRATION REACTIONS; DIELS-ALDER; DIELS-ALDER CYCLOADDITIONS; FEEDING EXPERIMENTS; INTRAMOLECULAR DIELS-ALDER REACTION; MACROCYCLIZATIONS; MACROLACTONIZATION; MODEL SUBSTRATES; MOLECULAR BASIS; POLYKETIDE METABOLITES; POLYKETIDES; QUINONE METHIDE; QUINONE METHIDES;

BIOCHEMISTRY; BIOSYNTHESIS; DEHYDRATION; GENES;

CYCLOADDITION;

ELANSOLID A; ELANSOLID B1; ELANSOLID B2; ELANSOLID B3; INDOLE DERIVATIVE; MACROLIDE; POLYKETIDE SYNTHASE; QUINONE METHIDE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; METABOLISM; MULTIGENE FAMILY; STEREOISOMERISM;

CATALYSIS; CYCLIZATION; INDOLEQUINONES; MACROLIDES; MOLECULAR STRUCTURE; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; STEREOISOMERISM;

EID: 79954622948     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201006880     Document Type: Article

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