Caenorhabditis elegans DNA-2 helicase/endonuclease plays a vital role in maintaining genome stability, morphogenesis, and life span

Biochemical and Biophysical Research Communications

Volumn 407, Issue 3, 2011, Pages 495-500

  Lee, Myon Hee ^a,b   Hollis, Sarah E ^a   Yoo, Bum Ho ^c   Nykamp, Keith ^d  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Yonsei University   (South Korea)

^d Center for Molecular Diagnostics and BioBanking   (United States)

Author keywords

Caenorhabditis elegans; Dna2; Genome stability; Life span; Morphogenesis; Replication

Indexed keywords

ENDONUCLEASE; HELICASE;

ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE ARREST; CELL DIVISION; CELL VIABILITY; DNA REPAIR; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE MUTATION; GENOMIC INSTABILITY; LIFESPAN; MALE; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA HELICASES; DNA REPLICATION; ENDODEOXYRIBONUCLEASES; GENOMIC INSTABILITY; LONGEVITY; MALE; MORPHOGENESIS; MUTATION; TAIL;

CAENORHABDITIS ELEGANS; EUKARYOTA;

EID: 79954621884     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.045     Document Type: Article

References (26)

1. Waga S., Stillman B. The DNA replication fork in eukaryotic cells. Annu. Rev. Biochem. 1998, 67:721-751.
2. Bae S.H., Bae K.H., Kim J.A., Seo Y.S. RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. Nature 2001, 412:456-461.
3. Bambara R.A., Murante R.S., Henricksen L.A. Enzymes and reactions at the eukaryotic DNA replication fork. J. Biol. Chem. 1997, 272:4647-4650.
4. Budd M.E., Campbell J.L. The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways. Mutat. Res. 2000, 459:173-186.
5. Budd M.E., Campbell J.L. Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair. PLoS One 2009, 4:e4267.
6. Fiorentino D.F., Crabtree G.R. Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase. Mol. Biol. Cell 1997, 8:2519-2537.
7. Henneke G., Koundrioukoff S., Hubscher U. Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene 2003, 22:4301-4313.
8. Lesur I., Campbell J.L. The transcriptome of prematurely aging yeast cells is similar to that of telomerase-deficient cells. Mol. Biol. Cell 2004, 15:1297-1312.
9. Lee K.H., Lee M.H., Lee T.H., Han J.W., Park Y.J., Ahnn J., Seo Y.S., Koo H.S. Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent. Mol. Cells 2003, 15:81-86.
10. Parrish J.Z., Yang C., Shen B., Xue D. CRN-1, a Caenorhabditis elegans FEN-1 homolog, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J. 2003, 22:3451-3460.
11. Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
12. Lee M.H., Park H., Shim G., Lee J., Koo H.S. Regulation of gene expression, cellular localization, and in vivo function of Caenorhabditis elegans DNA topoisomerase I. Genes Cells 2001, 6:303-312.
13. Budd M.E., Campbell J.L. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. Mol. Cell Biol. 1997, 17:2136-2142.
14. Chin G.M., Villeneuve A.M. C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint. Genes Dev. 2001, 15:522-534.
15. Lee M.H., Han S.M., Han J.W., Kim Y.M., Ahnn J., Koo H.S. Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development. FEBS Lett. 2003, 555:250-256.
16. Mouhamad S., Galluzzi L., Zermati Y., Castedo M., Kroemer G. Apaf-1 deficiency causes chromosomal instability. Cell Cycle 2007, 6:3103-3107.
17. Zermati Y., Mouhamad S., Stergiou L., Besse B., Galluzzi L., Boehrer S., Pauleau A.L., Rosselli F., D'Amelio M., Amendola R., Castedo M., Hengartner M., Soria J.C., Cecconi F., Kroemer G. Non-apoptotic role for Apaf-1 in the DNA damage checkpoint. Mol. Cell 2007, 28:624-637.
18. Labouesse M. Deficiency screen based on the monoclonal antibody MH27 to identify genetic loci required for morphogenesis of the Caenorhabditis elegans embryo. Dev. Dyn. 1997, 210:19-32.
19. Podbilewicz B., White J.G. Cell fusions in the developing epithelial of C. elegans. Dev. Biol. 1994, 161:408-424.
20. Encalada S.E., Martin P.R., Phillips J.B., Lyczak R., Hamill D.R., Swan K.A., Bowerman B. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Dev. Biol. 2000, 228:225-238.
21. Emmons S.W., Lipton J. Genetic basis of male sexual behavior. J. Neurobiol. 2003, 54:93-110.
22. Hoopes L.L., Budd M., Choe W., Weitao T., Campbell J.L. Mutations in DNA replication genes reduce yeast life span. Mol. Cell Biol. 2002, 22:4136-4146.
23. Choe W., Budd M., Imamura O., Hoopes L., Campbell J.L. Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol. Cell Biol. 2002, 22:4202-4217.
24. Tomita K., Kibe T., Kang H.Y., Seo Y.S., Uritani M., Ushimaru T., Ueno M. Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Mol. Cell Biol. 2004, 24:9557-9567.
25. Sulston J.E., Horvitz H.R. Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol. 1977, 56:110-156.
26. Emmons S.W. Male development. WormBook 2005, 1-22.