The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1262-1268

  Malkova, Ludise ^a   Kozikowski, Alan P ^a,b   Gale, Karen ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

AChE inhibitor; Alzheimer's disease; Ampakine; Pigtail macaques

Indexed keywords

7 CHLORO 3,4 DIHYDRO 3 METHYL 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ACETYLCHOLINE; HUPERZINE A;

ACCURACY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; MACACA NEMESTRINA; MALE; MENTAL PERFORMANCE; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; TASK PERFORMANCE; VISUAL MEMORY; ADULT ANIMAL; ALZHEIMER DISEASE; ANIMAL MODEL; BRAIN FUNCTION; COGNITIVE DEFECT; CORRELATION ANALYSIS; DRUG EFFECT; MENTAL TASK; TRAINING;

ALKALOIDS; ANIMALS; BENZOTHIADIAZINES; CHOLINESTERASE INHIBITORS; COGNITION; FEMALE; HUMANS; MACACA; MALE; MEMORY; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; PATTERN RECOGNITION, VISUAL; RECEPTORS, AMPA; RECOGNITION (PSYCHOLOGY); SESQUITERPENES;

EID: 79954613012     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.12.018     Document Type: Article

References (58)

1. Y. Aracava, E.F. Pereira, M. Akkerman, M. Adler, and E.X. Albuquerque Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine J. Pharmacol. Exp. Ther. 331 2009 1014 1024
2. A. Arai, A. Guidotti, E. Costa, and G. Lynch Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices Neuroreport 7 1996 2211 2215 (Pubitemid 26361848)
3. A.C. Arai, and M. Kessler Pharmacology of ampakine modulators: From AMPA receptors to synapses and behavior Curr. Drug Targets 8 2007 583 602 (Pubitemid 46785059)
4. M. Bertolino, M. Baraldi, C. Parenti, D. Braghiroli, M. DiBella, S. Vicini, and E. Costa Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus Recept. Channels 1 1993 267 278 (Pubitemid 2036636)
5. M.D. Black Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data Psychopharmacology (Berl.) 179 2005 154 163 (Pubitemid 40584805)
6. Braida, D., Sala, M., 2001. Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. 7, 369-386.
7. J.J. Buccafusco, T. Weiser, K. Winter, K. Klinder, and A.V. Terry The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys Neuropharmacology 46 2004 10 22 (Pubitemid 37494735)
8. A. Chatterjee, M.K. Morris, D. Bowers, D.J. Williamson, L. Doty, and K.M. Heilman Cholinergic treatment of an amnestic man with a basal forebrain lesion: theoretical implications J. Neurol. Neurosurg. Psychiatry 56 1993 1282 1289 (Pubitemid 24008463)
9. D.H. Cheng, and X.C. Tang Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities Pharmacol. Biochem. Behav. 60 1998 377 386 (Pubitemid 28282678)
10. V. Dumery, P. Derer, and D. Blozovski Enhancement of passive avoidance learning through small doses of intra-amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase Dev. Psychobiol. 21 1988 553 565
11. S. Eckert, P. Eyer, and F. Worek Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge Toxicology 233 2007 180 186 (Pubitemid 46498383)
12. A. Ennaceur, and K. Meliani A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory Behav. Brain Res. 51 1992 83 92
13. Flynn, A.M., Malkova, L., Giampaolo, C.M., Williams, L.D., Kozikowski, A.P., Gale, K. 2000. Effects of Huperzine on Recognition Memory in Monkeys. Program No 75212 Neuroscience Meeting Planner New Orleans, LA: Society for Neuroscience, Online.
14. Gale, K., Barrow, K.V., Kozikowski, A.P., Malkova, L., 2001. IDRA 21 improves recognition memory in normal monkeys. Program No 9511 Neuroscience Meeting Planner San Diego, CA Society for Neuroscience, Online.
15. Y. Gao, X.C. Tang, L.C. Guan, and P.Z. Kuang Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick Acta Pharmacol. Sin. 21 2000 1169 1173 (Pubitemid 32012729)
16. S.J. Geib, W. Tuckmantel, and A.P. Kozikowski Huperzine A-a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease Acta Crystallogr. C 47 Pt 4 1991 824 827
17. R.K. Gordon, S.V. Nigam, J.A. Weitz, J.R. Dave, B.P. Doctor, and H.S. Ved The NMDA receptor ion channel: a site for binding of Huperzine A J. Appl. Toxicol. 21 Suppl. 1 2001 S47 S51
18. R.K. Gordon, J.R. Haigh, G.E. Garcia, S.R. Feaster, M.A. Riel, D.E. Lenz, P.S. Aisen, and B.P. Doctor Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman Chem. Biol. Interact. 157-158 2005 239 246 (Pubitemid 41757657)
19. J.R. Haigh, S.R. Johnston, A. Peppernay, P.J. Mattern, G.E. Garcia, B.P. Doctor, R.K. Gordon, and P.S. Aisen Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase Chem. Biol. Interact. 175 2008 380 386
20. M. Ingvar, J. Ambros-Ingerson, M. Davis, R. Granger, M. Kessler, G.A. Rogers, R.S. Schehr, and G. Lynch Enhancement by an ampakine of memory encoding in humans Exp. Neurol. 146 1997 553 559 (Pubitemid 27381863)
21. A.P. Kozikowski, C.P. Miller, F. Yamada, Y.P. Pang, J.H. Miller, M. McKinney, and R.G. Ball Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity J. Med. Chem. 34 1991 3399 3402
22. G. Lallement, V. Baille, D. Baubichon, P. Carpentier, J.M. Collombet, P. Filliat, A. Foquin, E. Four, C. Masqueliez, G. Testylier, L. Tonduli, and F. Dorandeu Review of the value of huperzine as pretreatment of organophosphate poisoning Neurotoxicology 23 2002 1 5 (Pubitemid 36559693)
23. G. Lallement, J.P. Demoncheaux, A. Foquin, D. Baubichon, M. Galonnier, D. Clarencon, and F. Dorandeu Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity Drug. Chem. Toxicol. 25 2002 309 320 (Pubitemid 34831281)
24. G. Lallement, J. Veyret, C. Masqueliez, S. Aubriot, M.F. Burckhart, and D. Baubichon Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality Fundam. Clin. Pharmacol. 11 1997 387 394 (Pubitemid 27402247)
25. Y.Q. Liang, and X.C. Tang Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats Acta Pharmacol. Sin. 27 2006 1127 1136
26. Y.Q. Liang, X.T. Huang, and X.C. Tang Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats Cell. Mol. Neurobiol. 28 2008 87 101 (Pubitemid 351251001)
27. G. Lynch AMPA receptor modulators as cognitive enhancers Curr. Opin. Pharm. 4 2004 4 11 (Pubitemid 38145831)
28. T.M. Myers, W. Sun, A. Saxena, B.P. Doctor, A.J. Bonvillain, and M.G. Clark Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects Pharmacol. Biochem. Behav. 94 2010 477 481
29. M. Miyamoto, S. Narumi, A. Nagaoka, and J.T. Coyle Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions J. Pharmacol. Exp. Ther. 248 1989 825 835 (Pubitemid 19090260)
30. M.J. O'Neill, D. Bleakman, D.M. Zimmerman, and E.S. Nisenbaum AMPA Receptor potentiators for the treatment of CNS disorders Curr. Drug Targets CNS Neurol. Disord. 3 2004 181 194 181 (Pubitemid 38854913)
31. H. Ogura, and T.G. Aigner MK-801 impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs J. Pharmacol. Exp. Ther. 266 1 1993 Jul 60 64 (Pubitemid 23315628)
32. L.Y. Ou, X.C. Tang, and J.X. Cai Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys Eur. J. Pharmacol. 433 2001 151 156 (Pubitemid 34045173)
33. J.E. Sweeney, E.S. Bachman, and J.T. Coyle Effects of different doses of galanthamine, a long-acting acetylcholinesterase inhibitor, on memory in mice Psychopharmacology (Berl.). 102 1990 191 200 (Pubitemid 20264658)
34. X.C. Tang, P. De Sarno, K. Sugaya, and E. Giacobini Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat J. Neurosci. Res. 24 1989 276 285 (Pubitemid 19261880)
35. X.C. Tang, G.H. Kindel, A.P. Kozikowski, and I. Hanin Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo J. Ethnopharmacol. 44 1994 147 155
36. D.M. Thompson, A. Guidotti, M. DiBella, and E. Costa 7-Chloro-3-methyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine S, S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys Proc. Natl. Acad. Sci. U.S.A. 92 1995 7667 7671
37. L.S. Tonduli, G. Testylier, C. Masqueliez, G. Lallement, and P. Monmaur Effects of Huperzine used as pre-treatment against soman-induced seizures Neurotoxicology 22 2001 29 37 (Pubitemid 32220685)
38. D.P. Uzunov, I. Zivkovich, W.H. Pirkle, E. Costa, and A. Guidotti Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S, S-dioxide, a cognition-enhancing benzothiadiazine derivative J. Pharm. Sci. 84 1995 937 942
39. H.S. Ved, M.L. Koenig, J.R. Dave, and B.P. Doctor Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate Neuroreport 8 1997 963 968 (Pubitemid 27152155)
40. B.S. Wang, H. Wang, Z.H. Wei, Y.Y. Song, L. Zhang, and H.Z. Chen Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis J. Neural. Transm. 116 2009 457 465
41. C. Wang, T. Zhang, H. Ma, J. Liu, F. Fu, and K. Liu Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine Basic Clin. Pharmacol. Toxicol. 100 2007 190 195
42. L.S. Wang, J. Zhou, X.M. Shao, and X.C. Tang Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia Brain Res. 949 2002 162 170 (Pubitemid 35246189)
43. R. Wang, and X.C. Tang Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease Neurosignals 14 2005 71 82 (Pubitemid 40868985)
44. R. Wang, H.Y. Zhang, and X.C. Tang Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat Eur. J. Pharmacol. 421 2001 149 156 (Pubitemid 32539415)
45. T. Wang, and X.C. Tang Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine Eur. J. Pharmacol. 349 1998 137 142 (Pubitemid 28277080)
46. Z.F. Wang, J. Wang, H.Y. Zhang, and X.C. Tang Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia J. Neurochem. 106 2008 1594 1603
47. Z.F. Wang, L.L. Tang, H. Yan, Y.J. Wang, and X.C. Tang Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice Pharmacol. Biochem. Behav. 83 2006 603 611 (Pubitemid 43817131)
48. Z.Q. Xiong, D.H. Cheng, and X.C. Tang Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit Zhongguo Yao Li Xue Bao 19 1998 128 132
49. S.S. Xu, Z.X. Gao, Z. Weng, Z.M. Du, W.A. Xu, J.S. Yang, M.L. Zhang, Z.H. Tong, Y.S. Fang, and X.S. Chai Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease Zhongguo Yao Li Xue Bao 16 1995 391 395
50. S.S. Xu, Z.Y. Cai, Z.W. Qu, R.M. Yang, Y.L. Cai, G.Q. Wang, X.Q. Su, X.S. Zhong, R.Y. Cheng, W.A. Xu, J.X. Li, and B. Feng Huperzine-A in capsules and tablets for treating patients with Alzheimer disease Zhongguo Yao Li Xue Bao 20 1999 486 490 (Pubitemid 29302406)
51. K.A. Yamada Modulating excitatory neurotransmission: potential treatment for neurological disease Neurobiol. Dis. 5 1998 67 80 (Pubitemid 28430717)
52. J.W. Ye, J.X. Cai, L.M. Wang, and X.C. Tang Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment J. Pharmacol. Exp. Ther. 288 1999 814 819 (Pubitemid 29119699)
53. J.W. Ye, Y.Z. Shang, Z.M. Wang, and X.C. Tang Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance Acta Pharmacol. Sin. 21 2000 65 69
54. A. Zangara The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease Pharmacol. Biochem. Behav. 75 2003 675 686 (Pubitemid 36939173)
55. Z. Zhang, X. Wang, Q. Chen, L. Shu, J. Wang, and G. Shan Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial Zhonghua Yi Xue Za Zhi 82 2002 941 944
56. J. Zhou, H.Y. Zhang, and X.C. Tang Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils Neurosci. Lett. 313 2001 137 140 (Pubitemid 33022589)
57. X.D. Zhu, and E. Giacobini Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines J. Neurosci. Res. 41 1995 828 835
58. I. Zivkovic, D.M. Thompson, M. Bertolino, D. Uzunov, M. DiBella, E. Costa, and A. Guidotti 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S, S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization J. Pharmacol. Exp. Ther. 272 1995 300 309