Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip - an emerging genetic overlap

Arthritis Research and Therapy

Volumn 13, Issue 2, 2011, Pages

  Loughlin, John ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GROWTH DIFFERENTIATION FACTOR 15; GROWTH DIFFERENTIATION FACTOR 5; TRANSFORMING GROWTH FACTOR BETA; SCLEROPROTEIN;

ALLELE; DEGENERATIVE DISEASE; DEVELOPMENTAL DISORDER; EDITORIAL; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HIP DYSPLASIA; HUMAN; KNEE OSTEOARTHRITIS; LUMBAR DISK; MUSCULOSKELETAL SYSTEM; PHENOTYPE; PLEIOTROPY; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN; CONGENITAL HIP DISLOCATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; NOTE;

ASIAN CONTINENTAL ANCESTRY GROUP; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HIP DISLOCATION, CONGENITAL; HUMANS; MALE; POLYMORPHISM, GENETIC;

EID: 79954611515     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3291     Document Type: Editorial

References (10)

1. Shi D, Dai J, Zhu P, Qin J, Zhu L, Zhu H, Zhao B, Qiu X, Xu Z, Chen D, Yi L, Ikegawa S, Jiang Q. Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese. Arthritis Res Ther 2011, 13:R27. 10.1186/ar3252, 21329514.
2. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet 2005, 37:138-144. 10.1038/ng1496, 15640800.
3. Song YQ, Cheung KM, Ho DW, Poon SC, Chiba K, Kawaguchi Y, Hirose Y, Alini M, Grad S, Yee AF, Leong JC, Luk KD, Karppinen J, Cheah KS, Sham P, Ikegawa S, Chan D. Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet 2008, 82:744-747. 10.1016/j.ajhg.2007.12.017, 2427233, 18304494.
4. Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S. Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem 2007, 282:32185-32192. 10.1074/jbc.M700522200, 17827158.
5. Kou I, Nakajima M, Ikegawa S. Binding characteristics of the osteoarthritis-associated protein asporin. J Bone Miner Metab 2010, 28:395-402. 10.1007/s00774-009-0145-8, 20052601.
6. Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, Gonzales A, Jiang Q, Kamatani N, Loughlin J, Ikegawa S. Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum Mol Genet 2007, 16:1676-1681. 10.1093/hmg/ddm115, 17517696.
7. Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R, Tsezou A, Malizos KN, Kloppenburg M, Shi D, Southam L, van der Breggen R, Donn R, Qin J, Doherty M, Slagboom PE, Wallis G, Kamatani N, Jiang Q, Gonzalez A, Loughlin J, Ikegawa S. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5'UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet 2008, 17:1497-1504. 10.1093/hmg/ddn038, 18299287.
8. Dai J, Shi D, Zhu P, Qin J, Ni H, Xu Y, Yao C, Zhu L, Zhu H, Zhao B, Wei J, Liu B, Ikegawa S, Jiang Q, Ding Y. Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study. Arthritis Res Ther 2008, 10:R126. 10.1186/ar2540, 2592816, 18947434.
9. Rouault K, Scotet V, Autret S, Gaucher F, Dubrana F, Tanguy D, El Rassi CY, Fenoll B, Férec C. Evidence of association between GDF5 polymorphisms and congenital dislocation of the hip in a Caucasian population. Osteoarthritis Cartilage 2010, 18:1144-1149. 10.1016/j.joca.2010.05.018, 20633687.
10. Williams F, Popham M, Hart D, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden N, Cooper C, Spector T, Valdes A, van Meurs J. GDF5 SNP rs143383 is associated with lumbar disc disease in northern European women. Arthritis Rheum 2010.