Immunoglobulin M antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi in chronic chagasic patients

Human Immunology

Volumn 72, Issue 5, 2011, Pages 402-405

  Vasconcelos, Romero H T ^a   Azevedo, Elisa A N ^a   Cavalcanti, Maria G A M ^b   Silva, Edimilson D ^a,c   Ferreira, Antonio G P ^a,c   Morais, Clarice N L ^a   Gomes, Yara M ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Instituto de Technologia em Imunobiologicos   (Brazil)

Author keywords

Chagas disease; Immunoglobulin M; Recombinant antigens; Trypanosoma cruzi

Indexed keywords

CYTOPLASMATIC REPETITIVE ANTIGEN; FLAGELLAR REPETITIVE ANTIGEN; IMMUNOGLOBULIN M ANTIBODY; PARASITE ANTIGEN; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMORAL IMMUNITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

EID: 79954607423     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.02.015     Document Type: Article

References (19)

1. Control of Chagas disease. WHO Tech Rep Ser 2002, 905:109. World Health Organization.
2. Dutra W.O., Rocha M.O.C., Teixeira M.M. The clinical immunology of human Chagas disease. Trends Parasitol 2005, 21:581-587.
3. Corrêa-Oliveira R., Gomes J.A.S., Lemos E.M., Cardoso G.M., Reis D.D., Adad S., et al. The role of the immune response on the development of severe clinical forms of human Chagas disease. Mem Inst Oswaldo Cruz 1999, 94:253-255.
4. Lorca M., Gonzalez A., Veloso C., Reyes V., Vergara U. Immunodetection of antibodies in sera from symptomatic and asymptomatic Chilean Chagas' disease patients with Trypanosoma cruzi recombinant antigens. Am J Trop Med Hyg 1992, 46:44-49.
5. Gazzinelli R.T., Leme V.M.C., Cancado J.R., Gazzinelli G., Scharfstein J. Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease. Infect Immun 1990, 58:1437-1444.
6. Magnani M.A.C., Ferriolli Filho F., de Siqueira A.F. [Specific immunoglobulins (IgA, IgG, and IgM) in serum of patients with chronic Chagas' disease analyzed by indirect immunofluorescence reactions]. Rev Inst Med Trop Sao Paulo 1973, 15:72-75.
7. Morgan J., Dias J.C.P., Gontijo E.D., Bahia-Oliveira L., Correa-Oliveira R., Colley D.G., et al. Anti-Trypanosoma cruzi antibody isotype profiles in patients with different clinical manifestations of Chagas' disease. Am J Trop Med Hyg 1996, 55:355-359.
8. Sá Ferreira J.A., Galvão-Castro B., Macedo W., Castro C. Immunoglobulins and other serological parameters in Chagas' disease: evidence for increased IgA levels in the chronic digestive form. Clin Exp Immunol 1983, 52:266-270.
9. Primavera K.S.C., Umezawa E.S., Peres B.A., Camargo M.E., Hoshino-Shimizu S. Chagas' disease: IgA, IgM and IgG antibodies to T cruzi amastigote, trypomastigote and epimastigote antigens in acute and in different chronic forms of the disease. Rev Inst Med Trop Sao Paulo 1990, 32:172-180.
10. Umezawa E.S., Shikanai-Yasuda M.A., Stolf A.M.S. Changes in isotype composition and antigen recognition of anti-Trypanosoma cruzi antibodies from acute to chronic Chagas disease. J Clin Lab Anal 1996, 10:407-413.
11. Betônico G.N., Miranda E.O., Silva D.A.O., Houghton R., Reed S.G., Campos-Neto A., et al. Evaluation of a synthetic tripeptide as antigen for detection of IgM and IgG antibodies to Trypanosoma cruzi in serum samples from patients with Chagas disease or viral diseases. Trans R Soc Trop Med Hyg 1999, 93:603-606.
12. Lafaille J.J., Linss J., Krieger M.A., Souto-Padrón T., de Souza W., Goldenberg S., et al. Structure and expression of two Trypanosoma cruzi genes encoding antigenic proteins bearing repetitive epitopes. Mol Biochem Parasitol 1989, 35:127-136.
13. Krieger M.A., Almeida E., Oelemann W., Lafaille J.J., Pereira J.B., Krieger H., et al. Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease. Am J Trop Med Hyg 1992, 46:427-434.
14. Verçosa A.F.A., Lorena V.M.B., Carvalho C.L., Melo M.F.A.D., Cavalcanti M.G.A., Silva E.D., et al. Chagas' disease: IgG isotypes against cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens of Trypanosoma cruzi in chronic chagasic patients. J Clin Lab Anal 2007, 21:271-276.
15. Vasconcelos R.H.T., Amaral F.N., Cavalcanti M.G.A.M., Silva E.D., Ferreira A.G.P., Morais C.N.L., et al. Increased levels of IgA antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi differentiate digestive forms of Chagas disease. Hum Immunol 2010, 71:964-967.
16. Antas P.R.Z., Azevedo E.M., Luz M.R.M.P., Medrano-Mercado N., Chaves A.C.L., Vidigal P.G., et al. A reliable and specific enzyme-linked immunosorbent assay for the capture of IgM from human chagasic sera using fixed epimastigotes of Trypanosoma cruzi. Parasitol Res 2000, 86:813-820.
17. Matsumoto T.K., Hoshino-Shimizu S., Nakamura P.M., Andrade H.F., Umezawa E.S. High resolution of Trypanosoma cruzi amastigote antigen in serodiagnosis of different clinical forms of Chagas' disease. J Clin Microbiol 1993, 31:1486-1492.
18. Zúñiga E., Montes C., Barbieri G., Gruppi A. Antibodies against Trypanosoma cruzi alkaline antigens are elicited in sera from acute but not chronic human chagasic patients. Clin Immunol 1999, 93:81-89.
19. Umezawa E.S., Nascimento M.S., Stolf A.M.S. Enzyme-linked immunosorbent assay with Trypanosoma cruzi excreted-secreted antigens (TESA-ELISA) for serodiagnosis of acute and chronic Chagas' disease. Diagn Microbiol Infect Dis 2001, 39:169-176.