Increased levels of IgA antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi differentiate digestive forms of Chagas disease

Human Immunology

Volumn 71, Issue 10, 2010, Pages 964-967

  Vasconcelos, Romero H T ^a   Amaral, Fábio N ^a   Cavalcanti, Maria G A M ^b   Silva, Edimilson D ^c   Ferreira, Antonio G P ^c   Morais, Clarice N L ^a   Gomes, Yara M ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Instituto de Technologia em Imunobiologicos   (Brazil)

Author keywords

Biologic markers; Chagas disease; Immunoglobulin A; Recombinant antigens; Trypanosoma cruzi

Indexed keywords

CYTOPLASMATIC REPETITIVE ANTIGEN; FLAGELLAR REPETITIVE ANTIGEN; IMMUNOGLOBULIN A ANTIBODY; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CHAGAS DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TRYPANOSOMA CRUZI;

EID: 77956619065     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.07.004     Document Type: Article

References (18)

1. Control of Chagas disease. WHO Tech Rep 2002, 905:109. World Health Organization.
2. Dutra W.O., Rocha M.O.C., Teixeira M.M. The clinical immunology of human Chagas disease. Trends Parasitol 2005, 21:581-587.
3. Abel L.C.J., Rizzo L.V., Ianni B., Albuquerque F., Bacal F., Carrara D., et al. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection. J Autoimmun 2001, 17:99-107.
4. Barros-Mazon S., Guariento M.E., Silva C.A., Coffman R.L., Abrahamsohn I.A. Differential regulation of lymphoproliferative responses to Trypanosoma cruzi antigen in patients with the cardiac or indeterminate form of Chagas disease. Clin Immunol 2004, 111:137-145.
5. Gomes J.A.S., Bahia-Oliveira L.M.G., Rocha M.O.C., Busek S.C.U., Teixeira M.M., Silva J.S., Correa-Oliveira R. Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients. Infect Immun 2005, 73:7960-7966.
6. Castro C., Macedo V., Rezende J.M., Prata A. Estudo Radiológico longitudinal do esÔfago, em área endêmica de doença de Chagas, em um período de 13 anos. Rev Soc Bras Med Trop 1994, 27:227-233.
7. Sá Ferreira J.A., Galvão-Castro B., Macedo W., Castro C. Immunoglobulins and other serological parameters in Chagas' disease: Evidence for increased IgA levels in the chronic digestive form. Clin Exp Immunol 1983, 52:266-270.
8. Primavera K.S.C., Hoshino-Shimizu S., Umezawa E.S., Peres B.A., Manigot D.A., Camargo M.E. Immunoglobulin A Antibodies to Trypanosoma cruzi Antigens in digestive forms of Chagas' disease. J Clin Microbiol 1988, 26:2101-2104.
9. Correa-Oliveira R., Gomes J.A.S., Lemos E.M., Cardoso G.M., Reis D.D., Adad S., et al. The role of the immune response on the development of severe clinical forms of human Chagas disease. Mem Inst Oswaldo Cruz 1999, 94:253-255.
10. Gazzinelli R.T., Leme V.M.C., Cançado J.R., Gazzinelli G., Scharfstein J. Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease. Infect Immun 1990, 58:1437-1444.
11. Lorca M., Gonzalez A., Veloso C., Reyes V., Vergara U. Immunodetection of antibodies in sera from symptomatic and asymptomatic Chilean Chagas' disease patients with Trypanosoma cruzi recombinant antigens. Am J Trop Med Hyg 1992, 46:44-49.
12. Morgan J., Dias J.C.P., Gontijo E.D., Bahia-Oliveira L., Correa-Oliveira R., Colley D.G., Powell M.R. Anti-Trypanosoma cruzi antibody isotype profiles in patients with different clinical manifestations of Chagas' disease. Am J Trop Med Hyg 1996, 55:355-359.
13. Motran C.C., Serra H.M., Gea S.E., Vullo C.M., Vottero-Cima E. Antibody isotypes profiles against Trypanosoma cruzi acidic antigens in two Ameridian populations from a Chagas' disease endemic area. Acta Trop 1994, 58:105-114.
14. Pereira-Chioccola V.L., Fragata-Filho A.A., Levy A.M.A., Rodrigues M.M., Schenkman S. Enzyme-linked immunoassay using recombinant trans-sialidase of Trypanosoma cruzi can be employed for monitoring of patients with Chagas' disease after drug treatment. Clin Diagn Lab Immunol 2003, 10:826-830.
15. Krieger M.A., Almeida E., Oelemann W., Lafaille J.J., Pereira J.B., Krieger H., et al. Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease. Am J Trop Med Hyg 1992, 46:427-434.
16. Lafaille J.J., Linss J., Krieger M.A., Souto-Padrón T., de Souza W., Goldenberg S. Structure and expression of two Trypanosoma cruzi genes encoding antigenic proteins bearing repetitive epitopes. Mol Biochem Parasitol 1989, 35:127-136.
17. Verçosa A.F.A., Lorena V.M.B., Carvalho C.L., Melo M.F.A.D., Cavalcanti M.G.A., Silva E.D., et al. Chagas' disease: IgG isotypes against cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens of Trypanosoma cruzi in chronic chagasic patients. J Clin Lab Anal 2007, 21:217-276.
18. Sterin-Borda L., Goin J.C., Bilder C.R., Iantorno G., Hernando A.C., Borda E. Interaction of human chagasic IgG with human colon muscarinic acetylcholine receptor: Molecular and functional evidence. Gut 2001, 49:699-705.