Low serum citrulline concentration correlates with catheter-related bloodstream infections in children with intestinal failure

Journal of Parenteral and Enteral Nutrition

Volumn 35, Issue 2, 2011, Pages 181-187

  Hull, Melissa A ^a,b   Jones, Brian A ^a,b   Zurakowski, David ^b   Raphael, Bram ^a,b   Lo, Clifford ^a,b   Jaksic, Tom ^a,b   Duggan, Christopher ^a,b  

^a Center for Advanced Intestinal Rehabilitation   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

biomarker; catheter related bloodstream infection; central venous catheter; citrulline

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; BILIRUBIN GLUCURONIDE; CITRULLINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; AMINO ACID BLOOD LEVEL; ARTICLE; BACILLUS; BIFIDOBACTERIUM; BILIRUBIN BLOOD LEVEL; BLOODSTREAM INFECTION; BODY HEIGHT; BODY WEIGHT; CANDIDA; CATHETER INFECTION; CENTRAL VENOUS CATHETER; CONTROLLED STUDY; CORRELATIONAL STUDY; ENTEROBACTER; ENTEROCOCCUS; ENTEROPATHY; ESCHERICHIA COLI; FEMALE; GASTROINTESTINAL MOTILITY DISORDER; GASTROSCHISIS; GESTATIONAL AGE; HIGH RISK PATIENT; HUMAN; INFANT; INTERNATIONAL NORMALIZED RATIO; INTESTINE ATRESIA; INTESTINE FAILURE; KLEBSIELLA; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; NECROTIZING ENTEROCOLITIS; NUTRITIONAL STATUS; PARENTERAL NUTRITION; PRIORITY JOURNAL; PSEUDOMONAS; RHODOCOCCUS; SMALL INTESTINE; STAPHYLOCOCCUS; STREPTOCOCCUS; VOLVULUS;

BACTEREMIA; BIOLOGICAL MARKERS; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CITRULLINE; CROSS INFECTION; FEMALE; HUMANS; INFANT; INTESTINAL DISEASES; LOGISTIC MODELS; MALE; PARENTERAL NUTRITION; RETROSPECTIVE STUDIES; TIME FACTORS;

EID: 79954604147     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607110381406     Document Type: Article

References (39)

1. Curis E., Nicolis I., Moinard C., et al. Almost all about citrulline in mammals. Amino Acids. 2005 ; 29: 177-205. (Pubitemid 41754486)
2. Windmueller HG, Spaeth AE Source and fate of circulating citrulline. Am J Physiol. 1981 ; 241: E473 - E480.
3. Levillain O., Hus-Citharel A., Morel F., Bankir L. Localization of arginine synthesis along rat nephron. Am J Physiol. 1990 ; 259 (6Pt2). F916 - F923.
4. Fitzgibbons S., Ching YA, Valim C., et al. Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. J Pediatr Surg. 2009 ; 44: 928-932.
5. Crenn P., Messing B., Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr. 2008 ; 27: 328-339.
6. Lutgens LC, Deutz N., Granzier-Peeters M., et al. Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients. Int J Radiat Oncol Biol Phys. 2004 ; 60: 275-285. (Pubitemid 39165495)
7. Lutgens L., Lambin P. Biomarkers for radiation-induced small bowel epithelial damage: an emerging role for plasma Citrulline. World J Gastroenterol. 2007 ; 13: 3033-3042. (Pubitemid 47045459)
8. Crenn P., De Truchis P., Neveux N., Galperine T., Cynober L., Melchior JC Plasma citrulline is a biomarker of enterocyte mass and an indicator of parenteral nutrition in HIV-infected patients. Am J Clin Nutr. 2009 ; 90: 587-594.
9. Papadia C., Sherwood RA, Kalantzis C., et al. Plasma citrulline concentration: a reliable marker of small bowel absorptive capacity independent of intestinal inflammation. Am J Gastroenterol. 2007 ; 102: 1474-1482. (Pubitemid 46976295)
10. Pappas PA, Saudubray JM, Tzakis AG, et al. Serum citrulline as a marker of acute cellular rejection for intestinal transplantation. Transplant Proc. 2002 ; 34: 915-917. (Pubitemid 34556857)
11. Gondolesi G., Fishbein T., Chehade M., et al. Serum citrulline is a potential marker for rejection of intestinal allografts. Transplant Proc. 2002 ; 34: 918-920. (Pubitemid 34556858)
12. Gondolesi G., Ghirardo S., Raymond K., et al. The value of plasma citrulline to predict mucosal injury in intestinal allografts. Am J Transplant. 2006 ; 6: 2786-2790. (Pubitemid 44571701)
13. Blijlevens NM, Lutgens LC, Schattenberg AV, Donnelly JP Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy. Bone Marrow Transplant. 2004 ; 34: 193-196. (Pubitemid 39136824)
14. Lutgens LC, Blijlevens NM, Deutz NE, Donnelly JP, Lambin P., de Pauw BE Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests. Cancer. 2005 ; 103: 191-199. (Pubitemid 39665473)
15. van Vliet MJ, Tissing WJ, Rings EH, et al. Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients. Pediatr Blood Cancer. 2009 ; 53: 1188-1194.
16. van der Velden WJ, Blijlevens NM, Feuth T., Donnelly JP Febrile mucositis in haematopoietic SCT recipients. Bone Marrow Transplant. 2009 ; 43: 55-60.
17. Herbers AH, Blijlevens NM, Donnelly JP, de Witte TJ Bacteraemia coincides with low citrulline concentrations after high-dose melphalan in autologous HSCT recipients. Bone Marrow Transplant. 2008 ; 42: 345-349.
18. Raman M., Gramlich L., Whittaker S., Allard JP Canadian home total parenteral nutrition registry: preliminary data on the patient population. Can J Gastroenterol. 2007 ; 21: 643-648. (Pubitemid 350200499)
19. D'Antiga L., Dhawan A., Davenport M., Mieli-Vergani G., Bjarnason I. Intestinal absorption and permeability in paediatric short-bowel syndrome: a pilot study. J Pediatr Gastroenterol Nutr. 1999 ; 29: 588-593. (Pubitemid 30346343)
20. Tizianello A., De Ferrari G., Garibotto G., Gurreri G., Robaudo C. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest. 1980 ; 65: 1162-1173.
21. Viale P., Stefani S. Vascular catheter-associated infections: a microbiological and therapeutic update. J Chemother. 2006 ; 18: 235-249. (Pubitemid 44098071)
22. van Waardenburg DA, de Betue CT, Luiking YC, Engel M., Deutz NE Plasma arginine and citrulline concentrations in critically ill children: strong relation with inflammation. Am J Clin Nutr. 2007 ; 86: 1438-1444. (Pubitemid 350126249)
23. Horan TC, Andrus M., Dudeck MA CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008 ; 36: 309-332. (Pubitemid 351763841)
24. Sondheimer JM, Asturias E., Cadnapaphornchai M. Infection and cholestasis in neonates with intestinal resection and long-term parenteral nutrition. J Pediatr Gastroenterol Nutr. 1998 ; 27: 131-137. (Pubitemid 28354942)
25. Hermans D., Talbotec C., Lacaille F., Goulet O., Ricour C., Colomb V. Early central catheter infections may contribute to hepatic fibrosis in children receiving long-term parenteral nutrition. J Pediatr Gastroenterol Nutr. 2007 ; 44: 459-463. (Pubitemid 46573229)
26. Ishizuka M., Nagata H., Takagi K., Kubota K. Femoral venous catheterization is a major risk factor for central venous catheter-related bloodstream infection. J Invest Surg. 2009 ; 22: 16-21.
27. Beckers MM, Ruven HJ, Seldenrijk CA, Prins MH, Biesma DH Risk of thrombosis and infections of central venous catheters and totally implanted access ports in patients treated for cancer. Thromb Res. 2009: 125: 318-321.
28. Beghetto MG, Victorino J., Teixeira L., de Azevedo MJ Parenteral nutrition as a risk factor for central venous catheter-related infection. JPEN J Parenter Enteral Nutr. 2005 ; 29: 367-373. (Pubitemid 44296705)
29. Ishizuka M., Nagata H., Takagi K., Kubota K. Total parenteral nutrition is a major risk factor for central venous catheter-related bloodstream infection in colorectal cancer patients receiving postoperative chemotherapy. Eur Surg Res. 2008 ; 41: 341-345.
30. Hanna HA, Raad I. Blood products: a significant risk factor for long-term catheter-related bloodstream infections in cancer patients. Infect Control Hosp Epidemiol. 2001 ; 22: 165-166. (Pubitemid 32233896)
31. Samaras P., Dold S., Braun J., et al. Infectious port complications are more frequent in younger patients with hematologic malignancies than in solid tumor patients. Oncology. 2008 ; 74: 237-244.
32. Hosoglu S., Akalin S., Kidir V., Suner A., Kayabas H., Geyik MF Prospective surveillance study for risk factors of central venous catheter-related bloodstream infections. Am J Infect Control. 2004 ; 32: 131-134. (Pubitemid 38620833)
33. Castelli GP, Pognani C., Stuani A., Cita M., Paladini R. Central venous catheter replacement in the ICU: new site versus guidewire exchange. Minerva Anestesiol. 2007 ; 73: 267-273. (Pubitemid 47034256)
34. van der Kooi TI, de Boer AS, Mannien J., et al. Incidence and risk factors of device-associated infections and associated mortality at the intensive care in the Dutch surveillance system. Intensive Care Med. 2007 ; 33: 271-278. (Pubitemid 46221232)
35. Balzan S., de Almeida Quadros C., de Cleva R., Zilberstein B., Cecconello I. Bacterial translocation: overview of mechanisms and clinical impact. J Gastroenterol Hepatol. 2007 ; 22: 464-471. (Pubitemid 46435001)
36. Sukhotnik I., Srugo I., Mogilner JG, Lurie M., Coran AG, Shaoul R. Effect of lactulose on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome. J Pediatr Gastroenterol Nutr. 2008 ; 46: 507-513.
37. O'Boyle CJ, MacFie J., Mitchell CJ, Johnstone D., Sagar PM, Sedman PC Microbiology of bacterial translocation in humans. Gut. 1998 ; 42: 29-35. (Pubitemid 28228384)
38. Lichtman SM Bacterial [correction of baterial] translocation in humans. J Pediatr Gastroenterol Nutr. 2001 ; 33: 1-10. (Pubitemid 32706116)
39. Sanders J., Pithie A., Ganly P., et al. A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother. 2008 ; 62: 809-815.