메뉴 건너뛰기




Volumn 25, Issue 3, 2011, Pages 234-242

Effects on locomotion, muscle, bone, and blood induced by a combination therapy eliciting weight-bearing stepping in nonassisted spinal cord-transected mice

Author keywords

Central pattern generator; Functional recovery; Mice; Paraplegia; Spinal cord injury; Spinal cord transected; Treadmill; Walking

Indexed keywords

APOMORPHINE; BENSERAZIDE; BUSPIRONE; LEVODOPA;

EID: 79954601076     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968310378753     Document Type: Article
Times cited : (23)

References (37)
  • 1
    • 79954583864 scopus 로고    scopus 로고
    • One degree of separation. Paralysis and spinal cord injury in the United States
    • Christopher and Dana Reeve Foundation, Short Hills, NJ: Christopher and Dana Reeve Foundation
    • Christopher and Dana Reeve Foundation. One Degree of Separation. Paralysis and Spinal Cord Injury in the United States. 2006 Consensus Conference. Short Hills, NJ: Christopher and Dana Reeve Foundation; 2009:1-28.
    • (2009) 2006 Consensus Conference , pp. 1-28
  • 2
    • 33645003586 scopus 로고    scopus 로고
    • Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
    • Dobkin B, Apple D, Barbeau H, et al. Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Neurology. 2006;66:484-493.
    • (2006) Neurology , vol.66 , pp. 484-493
    • Dobkin, B.1    Apple, D.2    Barbeau, H.3
  • 3
    • 63249087731 scopus 로고    scopus 로고
    • Treadmill training after spinal cord injury: It's not just about the walking
    • Hicks AL, Ginis KA. Treadmill training after spinal cord injury: it's not just about the walking. J Rehabil Res Dev. 2008;45:241-248.
    • (2008) J Rehabil Res Dev , vol.45 , pp. 241-248
    • Hicks, A.L.1    Ginis, K.A.2
  • 5
    • 0033499581 scopus 로고    scopus 로고
    • Metabolic and endocrine changes in persons aging with spinal cord injury
    • Bauman WA, Spungen AM, Adkins RH, Kemp BJ. Metabolic and endocrine changes in persons aging with spinal cord injury. Assist Technol. 1999;11:88-96. (Pubitemid 30367255)
    • (1999) Assistive Technology , vol.11 , Issue.2 , pp. 88-96
    • Bauman, W.A.1    Spungen, A.M.2    Adkins, R.H.3    Kemp, B.J.4
  • 7
    • 59349084326 scopus 로고    scopus 로고
    • Immune depression syndrome following human spinal cord injury (SCI): A pilot study
    • Riegger T, Conrad HJ, Schluesener HP, et al. Immune depression syndrome following human spinal cord injury (SCI): a pilot study. Neuroscience. 2009;158:1194-1199.
    • (2009) Neuroscience , vol.158 , pp. 1194-1199
    • Riegger, T.1    Conrad, H.J.2    Schluesener, H.P.3
  • 9
    • 77950674160 scopus 로고    scopus 로고
    • Oral administration of a tri-therapy for central pattern generator activation in paraplegic mice: Proof-of-concept of efficacy
    • Guertin PA, Ung RV, Rouleau P. Oral administration of a tri-therapy for central pattern generator activation in paraplegic mice: proof-of-concept of efficacy. Biotechnol J. 2010; 5:421-426.
    • (2010) Biotechnol J , vol.5 , pp. 421-426
    • Guertin, P.A.1    Ung, R.V.2    Rouleau, P.3
  • 10
    • 57049141499 scopus 로고    scopus 로고
    • A technological platform to optimize combinatorial treatment design and discovery for chronic spinal cord injury
    • Guertin PA. A technological platform to optimize combinatorial treatment design and discovery for chronic spinal cord injury. J Neurosci Res. 2008;86:3039-3051.
    • (2008) J Neurosci Res , vol.86 , pp. 3039-3051
    • Guertin, P.A.1
  • 11
    • 33947617718 scopus 로고    scopus 로고
    • Hormonal and immunological changes in mice after spinal cord injury
    • DOI 10.1089/neu.2006.0117
    • Rouleau P, Ung RV, Lapointe NP, Guertin PA. Hormonal and immunological changes in mice after spinal cord injury. J Neurotrauma. 2007;24:367-378. (Pubitemid 46492157)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.2 , pp. 367-378
    • Rouleau, P.1    Ung, R.-V.2    Lapointe, N.P.3    Guertin, P.A.4
  • 12
    • 4143090324 scopus 로고    scopus 로고
    • Body weight, limb size, and muscular properties of early paraplegic mice
    • DOI 10.1089/0897715041651060
    • Landry E, Frenette J, Guertin PA. Body weight, limb size, and muscular properties of early paraplegic mice. J Neurotrauma. 2004;21:1008-1016. (Pubitemid 39096851)
    • (2004) Journal of Neurotrauma , vol.21 , Issue.8 , pp. 1008-1016
    • Landry, E.1    Frenette, J.2    Guertin, P.A.3
  • 13
    • 0018320226 scopus 로고
    • On the central generation of locomotion in the low spinal cat
    • Grillner S, Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res. 1979;34: 241-261. (Pubitemid 9249372)
    • (1979) Experimental Brain Research , vol.34 , Issue.2 , pp. 241-261
    • Grillner, S.1    Zangger, P.2
  • 14
    • 1542509410 scopus 로고    scopus 로고
    • Synergistic activation of the central pattern generator for locomotion by L-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice
    • DOI 10.1016/j.neulet.2003.12.120, PII S0304394004000643
    • Guertin PA. Synergistic activation of the central pattern generator for locomotion by l-beta-3, 4-dihydroxyphenylalanine and quipazine in adult paraplegic mice. Neurosci Lett. 2004;358:71-74. (Pubitemid 38340723)
    • (2004) Neuroscience Letters , vol.358 , Issue.2 , pp. 71-74
    • Guertin, P.A.1
  • 15
    • 33746191363 scopus 로고    scopus 로고
    • 7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice
    • DOI 10.1111/j.1460-9568.2006.04917.x
    • Landry ES, Lapointe NP, Rouillard C, Levesque D, Hedlund PB, Guertin PA. Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice. Eur J Neurosci. 2006;24:535-546. (Pubitemid 44100345)
    • (2006) European Journal of Neuroscience , vol.24 , Issue.2 , pp. 535-546
    • Landry, E.S.1    Lapointe, N.P.2    Rouillard, C.3    Levesque, D.4    Hedlund, P.B.5    Guertin, P.A.6
  • 16
    • 55249111277 scopus 로고    scopus 로고
    • Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice
    • Lapointe NP, Guertin PA. Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice. J Neurophysiol. 2008;100:160-168.
    • (2008) J Neurophysiol , vol.100 , pp. 160-168
    • Lapointe, N.P.1    Guertin, P.A.2
  • 17
    • 63849257600 scopus 로고    scopus 로고
    • Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates
    • Lapointe NP, Rouleau P, Ung RV, Guertin PA. Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates. J Physiol. 2009;587:1499-1511.
    • (2009) J Physiol , vol.587 , pp. 1499-1511
    • Lapointe, N.P.1    Rouleau, P.2    Ung, R.V.3    Guertin, P.A.4
  • 18
    • 56749170806 scopus 로고    scopus 로고
    • Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection
    • Ung RV, Landry E, Rouleau P, Lapointe NP, Rouillard C, Guertin PA. Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection. Eur J Neurosci. 2008;28: 2231-2242.
    • (2008) Eur J Neurosci , vol.28 , pp. 2231-2242
    • Ung, R.V.1    Landry, E.2    Rouleau, P.3    Lapointe, N.P.4    Rouillard, C.5    Guertin, P.A.6
  • 19
    • 0026737329 scopus 로고
    • Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat
    • Cazalets JR, Sqalli-Houssaini Y, Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol. 1992;455: 187-204.
    • (1992) J Physiol , vol.455 , pp. 187-204
    • Cazalets, J.R.1    Sqalli-Houssaini, Y.2    Clarac, F.3
  • 20
    • 0033596515 scopus 로고    scopus 로고
    • An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks
    • DOI 10.1016/S0006-8993(98)01199-8, PII S0006899398011998
    • Jiang Z, Carlin KP, Brownstone RM. An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Res. 1999;816:493-499. (Pubitemid 29225399)
    • (1999) Brain Research , vol.816 , Issue.2 , pp. 493-499
    • Jiang, Z.1    Carlin, K.P.2    Brownstone, R.M.3
  • 21
    • 61449259994 scopus 로고    scopus 로고
    • Levodopa for Parkinson's disease
    • Gerard JM, Elosegi JA. Levodopa for Parkinson's disease. N Engl J Med. 2009;360:936.
    • (2009) N Engl J Med , vol.360 , pp. 936
    • Gerard, J.M.1    Elosegi, J.A.2
  • 22
    • 52649130868 scopus 로고    scopus 로고
    • Anxiolytics may promote locomotor function recovery in spinal cord injury patients
    • Guertin PA. Anxiolytics may promote locomotor function recovery in spinal cord injury patients. Neuropsychiatr Dis Treat. 2008;4:759-763.
    • (2008) Neuropsychiatr Dis Treat , vol.4 , pp. 759-763
    • Guertin, P.A.1
  • 23
    • 34948908635 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of Levodopa in the treatment of Parkinson's disease
    • DOI 10.2174/157488407781668802
    • Khor SP, Hsu A. The pharmacokinetics and pharmacodynamics of levodopa in the treatment of Parkinson's disease. Curr Clin Pharmacol. 2007;2:234-243. (Pubitemid 47520962)
    • (2007) Current Clinical Pharmacology , vol.2 , Issue.3 , pp. 234-243
    • Khor, S.-P.1    Hsu, A.2
  • 24
    • 15944369310 scopus 로고    scopus 로고
    • Semiquantitative assessment of hindlimb movement recovery without intervention in adult paraplegic mice
    • DOI 10.1038/sj.sc.3101701
    • Guertin PA. Semiquantitative assessment of hindlimb movement recovery without intervention in adult paraplegic mice. Spinal Cord. 2005;43:162-166. (Pubitemid 40432660)
    • (2005) Spinal Cord , vol.43 , Issue.3 , pp. 162-166
    • Guertin, P.A.1
  • 25
    • 34247874606 scopus 로고    scopus 로고
    • Spontaneous recovery of hindlimb movement in completely spinal cord transected mice: A comparison of assessment methods and conditions
    • DOI 10.1038/sj.sc.3101970, PII 3101970
    • Ung RV, Lapointe N, Tremblay C, Larouche A, Guertin PA. Spontaneous recovery of hindlimb movement in completely spinal cord transected mice: a comparison of assessment methods and conditions. Spinal Cord. 2007;45: 367-379. (Pubitemid 46701465)
    • (2007) Spinal Cord , vol.45 , Issue.5 , pp. 367-379
    • Ung, R.V.1    Lapointe, N.P.2    Tremblay, C.3    Larouche, A.4    Guertin, P.A.5
  • 26
    • 0036460098 scopus 로고    scopus 로고
    • 2 agonist
    • DOI 10.1046/j.1460-9568.2002.02088.x
    • Antri M, Orsal D, Barthe JY. Locomotor recovery in the chronic spinal rat: effects of long-term treatment with a 5-HT2 agonist. Eur J Neurosci. 2002;16:467-476. (Pubitemid 35471865)
    • (2002) European Journal of Neuroscience , vol.16 , Issue.3 , pp. 467-476
    • Antri, M.1    Orsal, D.2    Barthe, J.-Y.3
  • 28
    • 0032814359 scopus 로고    scopus 로고
    • Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats
    • DOI 10.1002/(SICI)1097-4598(199907)22:7<846::AID-MUS6>3.0.CO;2-I
    • Houle JD, Morris K, Skinner RD, Garcia-Rill E, Peterson CA. Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats. Muscle Nerve. 1999;22:846-856. (Pubitemid 29330031)
    • (1999) Muscle and Nerve , vol.22 , Issue.7 , pp. 846-856
    • Houle, J.D.1    Morris, K.2    Skinner, R.D.3    Garcia-Rill, E.4    Peterson, C.A.5
  • 29
    • 0025898820 scopus 로고
    • Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs
    • Barbeau H, Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res. 1991;546:250-260.
    • (1991) Brain Res , vol.546 , pp. 250-260
    • Barbeau, H.1    Rossignol, S.2
  • 30
    • 70349524957 scopus 로고    scopus 로고
    • Transformation of non-functional spinal circuits into functional states after the loss of brain input
    • Courtine G, Gerasimenko Y, van den Brand R, et al. Transformation of non-functional spinal circuits into functional states after the loss of brain input. Nat Neurosci. 2009;12: 1333-1342.
    • (2009) Nat Neurosci , vol.12 , pp. 1333-1342
    • Courtine, G.1    Gerasimenko, Y.2    Van Den Brand, R.3
  • 31
    • 58149459320 scopus 로고    scopus 로고
    • Robotic training and spinal cord plasticity
    • Edgerton VR, Roy RR. Robotic training and spinal cord plasticity. Brain Res Bull. 2009;78:4-12.
    • (2009) Brain Res Bull , vol.78 , pp. 4-12
    • Edgerton, V.R.1    Roy, R.R.2
  • 32
    • 0018865214 scopus 로고
    • The locomotion of the low spinal cat. I. Coordination within a hindlimb
    • Forssberg H, Grillner S, Halbertsma J, Rossignol S. The locomotion of the low spinal cat. I. Coordination within a hindlimb. Acta Physiol Scand. 1980;108:269-281. (Pubitemid 10146956)
    • (1980) Acta Physiologica Scandinavica , vol.108 , Issue.3 , pp. 269-281
    • Forssberg, H.1    Grillner, S.2    Halbertsma, J.3
  • 33
    • 36749084556 scopus 로고    scopus 로고
    • Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis
    • DOI 10.1016/j.brainresrev.2007.06.025, PII S0165017307001403, Networks in Motion
    • Brownstone RM, Wilson JM. Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis. Brain Res Rev. 2008;57:64-76. (Pubitemid 350213100)
    • (2008) Brain Research Reviews , vol.57 , Issue.1 , pp. 64-76
    • Brownstone, R.M.1    Wilson, J.M.2
  • 36
    • 0035143214 scopus 로고    scopus 로고
    • Artificial neural network model for the generation of muscle activation patterns for human locomotion
    • DOI 10.1016/S1050-6411(00)00038-9, PII S1050641100000389
    • Prentice SD, Patla AE, Stacey DA. Artificial neural network model for the generation of muscle activation patterns for human locomotion. J Electromyogr Kinesiol. 2001;11: 19-30. (Pubitemid 32107002)
    • (2001) Journal of Electromyography and Kinesiology , vol.11 , Issue.1 , pp. 19-30
    • Prentice, S.D.1    Patla, A.E.2    Stacey, D.A.3
  • 37
    • 2942738757 scopus 로고    scopus 로고
    • Bipedal animals and their differences from humans
    • DOI 10.1111/j.0021-8782.2004.00289.x
    • Alexander RM. Bipedal animals, and their differences from humans. J Anat. 2004;204:321-330. (Pubitemid 38786683)
    • (2004) Journal of Anatomy , vol.204 , Issue.5 , pp. 321-330
    • Alexander, R.McN.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.