The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14670-14680

  Kawai, Masanobu ^a,b   Breggia, Anne C ^a   Demambro, Victoria E ^a   Shen, Xinchun ^c   Canalis, Ernesto ^d   Bouxsein, Mary L ^e   Beamer, Wesley G ^f   Clemmons, David R ^c   Rosen, Clifford J ^a  

^a Maine Medical Center Research Institute   (United States)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENESIS; AKT PHOSPHORYLATION; BINDING PROTEINS; BIOLOGIC ACTIVITIES; BONE FORMATION RATES; BONE MARROW STROMAL CELLS; BONE MASS; BONE RESORPTION; CATENIN SIGNALING; CYTOSOLIC; DATA SUPPORT; EX-VIVO; HEPARIN BINDING; IN-VITRO; INSULIN-LIKE GROWTH FACTOR; PTEN EXPRESSION; TRABECULAR BONES; TRANSPORT PROTEINS;

AMINO ACIDS; BONE; INSULIN; OSTEOBLASTS; PHOSPHORYLATION; POLYSACCHARIDES; SIGNALING;

PEPTIDES;

BETA CATENIN; HEPARIN; LYSYLHISTIDINYLLEUCYLSERYLLEUCYLGLUTAMYLGLUTAMYLPROPYLLYSYLLYSYLLEUCYLARGINYLPROLINE; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MARROW CELL; BONE MASS; CALVARIA; CONTROLLED STUDY; CYTOSOL; ENZYME PHOSPHORYLATION; IN VITRO STUDY; METACARPAL BONE; MINERALIZATION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROMA CELL; TRABECULAR BONE;

3T3 CELLS; ANIMALS; BETA CATENIN; BONE MARROW CELLS; FEMALE; HEPARIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; WNT PROTEINS;

MUS;

EID: 79954596670     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.193334     Document Type: Article

References (47)

1. Hwa, V., Oh, Y., and Rosenfeld, R. G. (1999) Endocr. Rev. 20, 761-787
2. Jones, J. I., and Clemmons, D. R. (1995) Endocr. Rev. 16, 3-34
3. Firth, S. M., and Baxter, R. C. (2002) Endocr. Rev. 23, 824-854
4. Hu, D., Pawlikowska, L., Kanaya, A., Hsueh, W. C., Colbert, L., Newman, A. B., Satterfield, S., Rosen, C., Cummings, S. R., Harris, T. B., and Ziv, E. (2009) J. Am. Geriatr. Soc. 57, 1213-1218
5. Hedbacker, K., Birsoy, K., Wysocki, R. W., Asilmaz, E., Ahima, R. S., Farooqi, I. S., and Friedman, J. M. (2010) Cell Metab. 11, 11-22
6. Wheatcroft, S. B., Kearney, M. T., Shah, A. M., Ezzat, V. A., Miell, J. R., Modo, M., Williams, S. C., Cawthorn, W. P., Medina-Gomez, G., Vidal-Puig, A., Sethi, J. K., and Crossey, P. A. (2007) Diabetes 56, 285-294
7. Hoeflich, A., Nedbal, S., Blum, W. F., Erhard, M., Lahm, H., Brem, G., Kolb, H. J., Wanke, R., and Wolf, E. (2001) Endocrinology 142, 1889-1898
8. Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F. J., Doran, P. M., and Khosla, S. (2002) Growth Horm. IGF Res. 12, 178-183
9. Khosla, S., Hassoun, A. A., Baker, B. K., Liu, F., Zein, N. N., Whyte, M. P., Reasner, C. A., Nippoldt, T. B., Tiegs, R. D., Hintz, R. L., and Conover, C. A. (1998) J. Clin. Invest. 101, 2165-2173
10. DeMambro, V. E., Clemmons, D. R., Horton, L. G., Bouxsein, M. L., Wood, T. L., Beamer, W. G., Canalis, E., and Rosen, C. J. (2008) Endocrinology 149, 2051-2061
11. Zhang, C. C., Kaba, M., Iizuka, S., Huynh, H., and Lodish, H. F. (2008) Blood 111, 3415-3423
12. Arai, T., Busby, W., Jr., and Clemmons, D. R. (1996) Endocrinology 137, 4571-4575
13. Russo, V. C., Bach, L. A., Fosang, A. J., Baker, N. L., and Werther, G. A. (1997) Endocrinology 138, 4858-4867
14. Russo, V. C., Rekaris, G., Baker, N. L., Bach, L. A., and Werther, G. A. (1999) Endocrinology 140, 3082-3090
15. Russo, V. C., Schütt, B. S., Andaloro, E., Ymer, S. I., Hoeflich, A., Ranke, M. B., Bach, L. A., and Werther, G. A. (2005) Endocrinology 146, 4445-4455
16. Duan, C., Ding, J., Li, Q., Tsai, W., and Pozios, K. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 15274-15279
17. Kawai, M., and Rosen, C. J. (2009) Pediatr. Nephrol. 24, 1277-1285
18. Liu, X., Bruxvoort, K. J., Zylstra, C. R., Liu, J., Cichowski, R., Faugere, M. C., Bouxsein, M. L., Wan, C., Williams, B. O., and Clemens, T. L. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 2259-2264
19. Mehrian-Shai, R., Chen, C. D., Shi, T., Horvath, S., Nelson, S. F., Reichardt, J. K., and Sawyers, C. L. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 5563-5568
20. Perks, C. M., Vernon, E. G., Rosendahl, A. H., Tonge, D., and Holly, J. M. (2007) Oncogene 26, 5966-5972
21. Levitt, R. J., Georgescu, M. M., and Pollak, M. (2005) Biochem. Biophys. Res. Commun. 336, 1056-1061
22. Sakata, T., Wang, Y., Halloran, B. P., Elalieh, H. Z., Cao, J., and Bikle, D. D. (2004) J. Bone Miner. Res 19, 436-446
23. Shoba, L. N., and Lee, J. C. (2003) J. Cell. Biochem. 88, 1247-1255
24. Wood, T. L., Rogler, L. E., Czick, M. E., Schuller, A. G., and Pintar, J. E. (2000) Mol. Endocrinol. 14, 1472-1482
25. Cohen, P., Peehl, D. M., Stamey, T. A., Wilson, K. F., Clemmons, D. R., and Rosenfeld, R. G. (1993) J. Clin. Endocrinol. Metab. 76, 1031-1035
26. Jin, T., George Fantus, I., and Sun, J. (2008) Cell Signal. 20, 1697-1704
27. Desbois-Mouthon, C., Cadoret, A., Blivet-Van Eggelpoël, M. J., Bertrand, F., Cherqui, G., Perret, C., and Capeau, J. (2001) Oncogene 20, 252-259
28. Playford, M. P., Bicknell, D., Bodmer, W. F., and Macaulay, V. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12103-12108
29. Amin, S., Riggs, B. L., Melton, L. J., 3rd, Achenbach, S. J., Atkinson, E. J., and Khosla, S. (2007) J. Bone Miner. Res. 22, 799-807
30. Fang, D., Hawke, D., Zheng, Y., Xia, Y., Meisenhelder, J., Nika, H., Mills, G. B., Kobayashi, R., Hunter, T., and Lu, Z. (2007) J. Biol. Chem. 282, 11221-11229
31. He, X. C., Yin, T., Grindley, J. C., Tian, Q., Sato, T., Tao, W. A., Dirisina, R., Porter-Westpfahl, K. S., Hembree, M., Johnson, T., Wiedemann, L. M., Barrett, T. A., Hood, L., Wu, H., and Li, L. (2007) Nat. Genet. 39, 189-198
32. Taurin, S., Sandbo, N., Qin, Y., Browning, D., and Dulin, N. O. (2006) J. Biol. Chem. 281, 9971-9976
33. Glass, D. A., 2nd, and Karsenty, G. (2006) Curr. Top. Dev. Biol. 73, 43-84
34. Palermo, C., Manduca, P., Gazzerro, E., Foppiani, L., Segat, D., and Barreca, A. (2004) Am. J. Physiol. Endocrinol. Metab. 286, E648-E657
35. Eckstein, F., Pavicic, T., Nedbal, S., Schmidt, C., Wehr, U., Rambeck, W., Wolf, E., and Hoeflich, A. (2002) Anat. Embryol. 206, 139-148
36. Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C., Koida, M., Ogita, K., and Komori, T. (2004) J. Cell Biol. 166, 85-95
37. Peng, X. D., Xu, P. Z., Chen, M. L., Hahn-Windgassen, A., Skeen, J., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., and Hay, N. (2003) Genes Dev. 17, 1352-1365
38. Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J., and Efstratiadis, A. (1993) Cell 75, 59-72
39. Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J. L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., and LeRoith, D. (2002) J. Clin. Invest. 110, 771-781
40. Zhang, M., Xuan, S., Bouxsein, M. L., von Stechow, D., Akeno, N., Faugere, M. C., Malluche, H., Zhao, G., Rosen, C. J., Efstratiadis, A., and Clemens, T. L. (2002) J. Biol. Chem. 277, 44005-44012
41. Zhao, G., Monier-Faugere, M. C., Langub, M. C., Geng, Z., Nakayama, T., Pike, J. W., Chernausek, S. D., Rosen, C. J., Donahue, L. R., Malluche, H. H., Fagin, J. A., and Clemens, T. L. (2000) Endocrinology 141, 2674-2682
42. Wang, Y., Nishida, S., Elalieh, H. Z., Long, R. K., Halloran, B. P., and Bikle, D. D. (2006) J. Bone Miner. Res. 21, 1350-1358
43. Gesta, S., Tseng, Y. H., and Kahn, C. R. (2007) Cell 131, 242-256
44. Liu, J., Wang, H., Zuo, Y., and Farmer, S. R. (2006) Mol. Cell. Biol. 26, 5827-5837
45. Bennett, C. N., Longo, K. A., Wright, W. S., Suva, L. J., Lane, T. F., Hankenson, K. D., and MacDougald, O. A. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3324-3329
46. Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., and MacDougald, O. A. (2000) Science 289, 950-953
47. Maile, L. A., Aday, A. W., Busby, W. H., Sanghani, R., Veluvolu, U., and Clemmons, D. R. (2008) J. Cell. Biochem. 105, 437-446