Relative distribution of drugs in decomposed skeletal tissue

Journal of Analytical Toxicology

Volumn 34, Issue 8, 2010, Pages 510-515

  Watterson, James H ^a   Desrosiers, Nathalie A ^a   Betit, Caroline C ^a   Dean, Dorothy ^b   Wyman, John F ^c  

^a LAURENTIAN UNIVERSITY   (Canada)

^b Summit County Medical Examiner's Office   (United States)

^c Franklin County Coroner's Office   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CITALOPRAM; DIAZEPAM; DRUG METABOLITE; METHANOL; MORPHINE; NORDAZEPAM; PENTOBARBITAL;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MATRIX; BONE TISSUE; CONTROLLED STUDY; DECOMPOSITION; DIAPHYSIS; DOMESTIC PIG; DRUG BONE LEVEL; DRUG DISTRIBUTION; DRUG EXPOSURE; EPIPHYSIS; FEMALE; FEMUR; FORENSIC TOXICOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMERUS; MALE; MASS FRAGMENTOGRAPHY; NONHUMAN; PELVIS; QUALITATIVE ANALYSIS; RIB; SCAPULA; SOLID PHASE EXTRACTION; TIBIA; VERTEBRA;

ANIMALIA; SUS SCROFA DOMESTICA;

EID: 79954584264     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/34.8.510     Document Type: Article

References (13)

1. I.M. McIntyre, C.V. King, M. Boratto, and O.H. Drummer. Postmortem drug analyses in bone and bone marrow. Ther. Drug Monit. 22: 79-83 (2000).
2. E.L. Horak and A.J. Jenkins. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J. Forensic Sci. 50: 679-681 (2005).
3. K.K. McGrath and A.J. Jenkins. Detection of drugs of forensic importance in postmortem bone. Am. J. Forensic Med. Pathol. 30(1): 40-44 (2009).
4. K. Kudo, H. Sugie, N. Syoui, K. Kurihara, N. Jitsufuchi, T. Imamura, and N. Ikeda. Detection of triazolam in skeletal remains buried for 4 years. Int. J. Leg. Med. 110: 281-283 (1997).
5. T.C. VandenBoer, S.A. Grummett, and J.H. Watterson. Utility of immunoassay in drug screening in skeletal tissues: sampling considerations in detection of ketamine exposure in femoral bone and bone marrow following acute administration using ELISA. J. Forensic Sci. 53: 1474-1482 (2008).
6. J.H. Watterson and J.E. Botman. Effects of tissue type and the dose-death interval on the detection of acute diazepam exposure in bone and marrow with solid-phase extraction, ELISA and liquid chromatography tandem mass spectrometry. J. Forensic Sci. 54(3): 708-714 (2009).
7. N.A. Desrosiers, C.C. Betit, and J.H. Watterson. Microwave assisted extraction in toxicological screening of skeletal tissues. Forensic Sci. Int. 188: 23-30 (2009).
8. N.M Lafreniere and J.H. Watterson. Detection of acute fentanyl exposure in fresh and decomposed skeletal tissues. Forensic Sci. Int. 185: 100-109 (2009).
9. P. Guillot, M. de Mazancourt, M. Durigon, and J.C. Alvarez, Morphine and 6-acetylmorphine concentrations in blood, brain, spinal cord, bone marrow and bone after lethal acute or chronic diacetylmorphine administration to mice. Forensic Sci. Int. 166: 139-144 (2007).
10. S. Ceigniz O. Ulukan, I. Ates, and H. Tugcu. Determination of morphine in postmortem rabbit bone marrow and comparison with blood morphine concentrations. Forensic Sci. Int. 156: 91- 94 (2006).
11. J.F.Wyman, D.E. Dean, R. Yinger, A. Simmons, D. Brobst, M. Bissell, F. Silveira, N. Kelly, R. Shott, J. Ohr, R. Howard, and B. Lewis. The temporal fate of drugs in decomposing porcine tissue. J. Forensic Sci., in press.
12. M.E. Kricun. Red-yellow marrow conversion: its effect on the location of some solitary bone lesions. Skeletal Radiol. 14: 10-19 (1985).
13. B. Levine, R.V. Blanke, and J.C.Valentour. Postmortem stability of benzodiazepines in blood and tissues. J. Forensic Sci. 28(1): 102- 115 (1983).