Testosterone relaxes abdominal aorta in male Sprague-Dawley rats by opening potassium (K+) channel and blockade of calcium (Ca2+) channel

Pathophysiology

Volumn 18, Issue 3, 2011, Pages 247-253

  Oloyo, Ahmed Kolade ^a   Sofola, Olusoga A ^a   Nair, Renuka R ^b   Harikrishnan, V S ^c   Fernandez, Adelaide C ^c  

^a UNIVERSITY OF LAGOS   (Nigeria)

^b GOVERNMENT MEDICAL COLLEGE   (India)

^c SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Calcium channel; Dehydroepiandrosterone; Non genomic; Potassium channel; Testosterone; Vascular relaxation

Indexed keywords

ANDROGEN RECEPTOR; APAMIN; AROMATASE; BARIUM CHLORIDE; CALCIUM CHANNEL L TYPE; CHARYBDOTOXIN; IBERIOTOXIN; INDOMETACIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; PRASTERONE; TESTOSTERONE PROPIONATE;

ABDOMINAL AORTA; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; VASODILATATION;

EID: 79954582438     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2011.02.004     Document Type: Article

References (49)

1. Liu P.Y., Death A.K., Handelsman D.J. Androgens and cardiovascular diseases. Endocr. Rev. 2003, 24(3):313-340.
2. Orshal J.M., Khalil R.A. Gender sex hormones and vascular tone. Am. J. Physiol. Regul. Integr Comp. Physiol. 2004, 286:R233-R249.
3. Hamm L. Testosterone propionate in the treatment of angina pectoris. J. Clin. Endocrinol. 1942, 2:325-328.
4. Walker T.C. Use of testosterone propionate and estrogenic substance in treatment of essential hypertension, angina pectoris and peripheral diseases. J. Clin. Endocrinol. 1942, 2:560-568.
5. English K.M., Steeds R.P., Jones T.H., Diver M.J., Channer K.S. Low dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina-a randomized, double-blind, placebo-controlled study. Circulation 2000, 102:1906-1911.
6. Pugh P.J., Jones R.D., West J.N., Jones T.H., Channer K.S. Testosterone treatment for men with chronic heart failure. Heart 2004, 90:446-447.
7. Malkin C.J., Jones T.H., Channer K.S. Testosterone in chronic heart failure. Front. Horm. Res. 2009, 37:183-196.
8. Quighey C.A., Debellis A., Marschke K.B., El-Awady M.K., Wilson E.M., French F.F. Androgen receptor defects: historical, clinical and molecular perspectives. Endocr. Rev. 1995, 16:271-321.
9. Heinlein C.A., Chang C. The roles of androgen receptors and androgen-binding proteins in non-genomic androgen actions. Mol. Endocrinol. 2002, 16:2181-2187.
10. Losel R., Wehling M. Non-genomic actions of steroid hormones. Nat. Rev. Mol Cell Biol. 2003, 4:46-55.
11. Luzardo O.P., Machin R.P., Diaz-Chico B.N., Fernandez L. Photo-affinity labeling identification of a specific protein for the anabolic steroids stanozolol and danazol: an ligomeric protein. Endocrinology 2000, 141:3377-3387.
12. Liu D., Dillon J.S. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Gαi2,3. J. Biol. Chem. 2002, 277:21379-21388.
13. Kahn S.M., Hryb D.J., Nakhla A.M., Romas N.A., Rosner W. Sex hormone-binding globulin is synthesized in target cells. J. Endocrinol. 2002, 175:113-120.
14. Khalil R.A. Sex hormones as potential modulators of vascular function in hypertension. Hypertension 2005, 46(2):249-254.
15. Yue P., Chatterjee K., Beale C., Poole-Wilson P.A., Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995, 91:1154-1160.
16. Jiang C.W., Sarrel P.M., Poole-Wilson P.A., Lindsay D.C., Collins P. Endothelium-independent relaxation of rabbit coronary artery by 17 beta-oestradiol in vitro. Br. J. Phamacol. 1991, 104:1033-1037.
17. Ding A.Q., Stallone J.N. Testosterone induce relaxation of rat aorta is androgen structure specific and involves K+ channel activation. J. Appl. Physiol. 2001, 91:2742-2750.
18. Kouloumenta V., Hatziefthimiou A., Parskeva E., Gourgoulianis K., Molyvdas P.A. Non-genomic effect of testosterone on airway smooth muscle. Br. J. Pharmacol. 2006, 149:1083-1091.
19. Seyrek M., Yildiz O., Ulusoy H.B., Yildirim V. Testosterone relaxes isolated human radial artery by potassium channel opening action. J. Pharmacol. Sci. 2007, 102:309-316.
20. Smith A.M., Bennet R.T., Jones T.H., Cowen M.E., Channer K.S., Jones R.D. Characterization of the vasodilatory action of testosterone in the pulmonary circulation. Vascular FDS Health Risk Manage. 2008, 4(6):1459-1466.
21. Yang J., Bevan R.D. Difference in sensitivity to exogenous norepinephrine of the abdominal aorta of the rabbit and branches of ventral origin. Fed Proc. 1981, 40:659. (Abst. 2541).
22. Tayo F.M., Bevan J.A. Extracellular calcium dependence of contraction and endothelium-dependent relaxation varies along the length of the aorta and its branches. J. Pharmacol. Exp. Ther. 1987, 240:594-601.
23. Adegunloye B.J., Sofola O.A. Differential responses of rat aorta and mesenteric artery to norepinepherine and serotonin in vitro. Pharmacology 1997, 55:25-31.
24. Salom J.B., Burgute M.C., Perez-Asensio F.J., Torregrosa G., Alborch E. Relaxant effect of 17-β-estradiol in cerebral arteries through Ca2+ entry inhibition. J. Cerebral Blood Flow Metab. 2001, 21:422-429.
25. Brindeiro C.M.T., Fallet R.W., Lane P.H., Carmines P.K. Potassium channel contribution to afferent arteriolar tone in normal and diabetic rat kidney. Am. J. Physiol. Renal Physiol. 2008, 295:F171-F178.
26. Ramu Y., Xu Y., Lu Z. Engineered specific and high affinity inhibitor for a subtype of inward rectifier K+ channels. PNAS 2008, 105(1):10774-10778.
27. Foradori C.D., Eiser M.J., Handa R.J. Non-genomic actions of androgens. Front Neuroendocrinol. 2008, 29(2):169-181.
28. Grino P.B., Griffin J.E., Wilson J.D. Testosterone at high concentration interacts with human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990, 126:1165-1172.
29. Harada N., Sasano H., Murakami H., Ohkuma T., Nagura H., Takai Y. Localised expression of aromatase in human vascular tissues. Circ. Res. 1999, 84:1285-1291.
30. Sasano H., Murakami H., Shizawa S., Satomi S., Nagura H., Harada N. Aromatase and sex steroid receptors in human vena cava. Endocr. J. 1999, 46:233-242.
31. Nathan L., Shi W., Dinh H., Mukherjee T.K., Wang X., Lusis A.J., Chaudhuri G. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc. Natl. Acad Sci. U.S.A. 2001, 98:3589-3593.
32. Murakami H., Harada N., Sasano H. Aromatase in atherosclerotic lesions of human aorta. J. Steroid Biochem. Mol. Biol. 2001, 79:67-74.
33. Ledoux J., Werner M.E., Brayden J.E., Nelson M.T. Calcium-activated potassium channels and the regulation of vascular tone. Physiology 2006, 21:69-79.
34. Adams D.J., Barakeh J., Laskey R., van Breemen C. Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J. 1989, 3:2389-2400.
35. Anfinogenova Y.J., Baskakov M.B., Kovalev I.V., Kilin A.A., Dulin N.O., Orlov S.N. Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and l-type Ca2+ channels. Pflugers Arch. 2004, 449:42-55.
36. Koltsova S.V., Maximov G.V., Kotelevtsev S.V., Lavoie J.L., Tremblay J., Grygorczyk R., Hamet P., Orlov S.N. Myogenic tone in mouse mesenteric arteries: evidence for P2Y receptor-mediated, Na+ K+, 2Cl- cotransport-dependent signaling. Purinergic Signal. 2009, 5:343-349.
37. Garg P., Martin C., Elms S.C., Gordon F.J., Wall S.M., Garland C.J., Sutliff R.L., O'Neil W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systematic blood pressure and smooth muscle tone. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H2100-H2105.
38. Koltsova S.V., Luneva O.G., Lavoie J.L., Tremblay J., Maksimov G.V., Hamet P., Orlov S.N. HCO3-dependent impact of Na+ K+, 2Cl- cotransport in vascular smooth muscle excitation-contraction coupling. Cell Physiol Biochem. 2009, 23:407-414.
39. Walter S.J., Shirley D.G., Folkerd E.J., Unwin R.J. Effects of the potassium channel blocker barium on sodium and potassium transport in the rat loop of Henle in vivo. Exp. Physiol. 2001, 86(4):469-474.
40. Hardy F.J., Vanhoutte P.M., Feletou M. Role of potassium in regulating blood flow and blood pressure. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R546-R552.
41. Cannel M.B., Sage S.O. Bradykinin-evoked changes in cytoplasmic calcium and membrane currents in cultured bovine pulmonary artery endothelial cells. J. Physiol. 1989, 419:555-568.
42. Coleman H.A., Tare M., Parkington H.C. Endothelial potassium channels, endothelium-dependent hyperpolarization, and the regulation of vascular tone in health and disease. Proc. Aust. Physiol. Pharmacol. Soc. 2004, 34:55-64.
43. Edward G., Dora K.A., Gardener M.J., Garland C.J., Weston A.H. K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 1998, 396:269-272.
44. Deenadayalu V., White R.E., Stallone J.N., Gao X., Garcia A.J. Testosterone relaxes coronary arteries by opening the large conductance, calcium-activated potassium channel. Am. J. Physiol. Heart Circ. Physiol. 2001, 281:H1720-H1727.
45. Quayle J.M., McCarron J.G., Brayden J.E., Nelson M.T. Inward rectifier K+ currents in smooth muscle from rat resistance-sized cerebral arteries. Am. J. Cell Physiol. 1993, 265:C1363-C1370.
46. Droogman G., Nilius B. Overview: potassium channels in vascular endothelial cells. Potassium Channels in Cardiovascular Biology 2001, 639-650. Kluwer Academic/Plenum, New York. S. Archer, N. Rush (Eds.).
47. Robertson B.E., Bonev A.D., Nelson M.T. Inward rectifier K+ currents in smooth muscle cells from rat coronary arteries: block by Mg2+ Ca2+ and Ba2+. Am. J Physiol. Heart Circ. Physiol. 1996, 271:H696-H705.
48. Quayle J.M., Dart C., Standen N.B. The properties and distribution of inward rectifier potassium current in pig coronary arterial smooth muscle. J. Physiol. 1996, 494:715-726.
49. Kim M.Y., Liang G.H., Kim J.A., Park S.H., Haj J.S., Suh S.H. Contribution of Na+-K+ pump and KIR currents to extracellular pH-dependent changes of contractility in rat superior mesenteric artery. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H792-H800.