Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is spread internationally by genetically distinct gonococcal populations

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 5, 2011, Pages 1186-1187

  Whiley, David M ^a,b   Goire, Namraj ^a,b   Lambert, Stephen B ^a,b   Nissen, Michael D ^a,b,c   Sloots, Theo P ^a,b,c   Tapsall, John W ^d  

^a Queensland Children's Medical Research Institute   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c Pathology Queensland Central   (Australia)

^d PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Gonorrhoea; MLST; Mosaic; penA; Resistance

Indexed keywords

CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; PENICILLIN BINDING PROTEIN 2A;

ANTIBIOTIC SENSITIVITY; AUSTRALIA; GONORRHEA; HONG KONG; JAPAN; KOREA; LETTER; NEISSERIA GONORRHOEAE; NONHUMAN; POLYMERASE CHAIN REACTION;

ANTI-BACTERIAL AGENTS; BACTERIAL TYPING TECHNIQUES; BETA-LACTAM RESISTANCE; CEFTRIAXONE; GENOTYPE; GONORRHEA; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; NEISSERIA GONORRHOEAE;

EID: 79954568895     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr052     Document Type: Letter

References (10)

1. Yokoi S, Deguchi T, Ozawa T et al. Threat to cefixime treatment for gonorrhea. Emerg Infect Dis 2007; 13: 1275-7.
2. Lo JYC, Ho KM, Leung AOC et al. Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. Antimicrob Agents Chemother 2008; 52: 3564-7.
3. Ito M, Deguchi T, Mizutani KS et al. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan. Antimicrob Agents Chemother 2005; 49: 137-43.
4. Tomberg J, Unemo M, Davies C et al. Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations. Biochemistry 2010; 49: 8062-70.
5. Whiley DM, Limnios EA, Ray S et al. Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. Antimicrob Agents Chemother 2007; 51: 3111-6.
6. Martin IM, Ison CA, Aanensen DM et al. Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J Infect Dis 2004; 189: 1497-505.
7. Unemo M, Fasth O, Fredlund H et al. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J Antimicrob Chemother 2009; 63: 1142-51.
8. Bennett JS, Jolley KA, Sparling PF et al. Species status of Neisseria gonorrhoeae: evolutionary and epidemiological inferences from multilocus sequence typing. BMC Biol 2007; 5: 35.
9. Ohnishi M, Watanabe Y, Ono E et al. Spread of a chromosomal cefixime-resistant penA gene among different Neisseria gonorrhoeae lineages. Antimicrob Agents Chemother 2010; 54: 1060-7.
10. Tapsall JW, Ray S, Limnios A. Characteristics and population dynamics of mosaic penA allele-containing Neisseria gonorrhoeae isolated in Sydney, Australia, 2007-2008. Antimicrob Agents Chemother 2010; 54: 554-6.