Exploring scarless healing of oral soft tissues

Journal of the Canadian Dental Association

Volumn 77, Issue , 2011, Pages

  Larjava, Hannu ^a   Wiebe, Colin ^a   Gallant Behm, Corrie ^b   Hart, David A ^c   Heino, Jyrki ^d   Häkkinen, Lari ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; DISEASE MODEL; HUMAN; INJURY; MOUTH MUCOSA; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; SCAR; SWINE; WOUND HEALING;

ANIMALS; CICATRIX; DISEASE MODELS, ANIMAL; HUMANS; MOUTH MUCOSA; REGENERATION; SWINE; WOUND HEALING;

EID: 79954565063     PISSN: 07098936     EISSN: 14882159     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr. 2006;18(4):396-402. (Pubitemid 44258997)
2. Durani P, Occleston N, O'Kane S, Ferguson MW. Avotermin: a novel antiscarring agent. Int J Low Extrem Wounds. 2008;7(3):160-8.
3. Gangemi EN, Gregori D, Berchialla P, Zingarelli E, Cairo M, Bollero D, et al. Epidemiology and risk factors for pathologic scarring after burn wounds. Arch Facial Plast Surg. 2008;10(2):93-102.
4. Ghahary A, Ghaffari A. Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar. Wound Repair Regen. 2007;15(Suppl 1): S46-53. (Pubitemid 47301674)
5. Erratum in Wound Repair Regen. 2008;16(4):582.
6. Verrecchia F, Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol. 2007;13(22):3056-62.
7. Armour A, Scott PG, Tredget EE. Cellular and molecular pathology of HTS: basis for treatment. Wound Repair Regen. 2007(Suppl 1);15:S6-17. (Pubitemid 47301668)
8. Erratum in Wound Repair Regen. 2008;16(4):582.
9. Clark R A F. Overview and general considerations of wound repair. In: The molecular and cellular biology of wound repair. New York: Plenum, 1996; p. 3-33.
10. Breathnack SM, McGrath JA. Wound healing. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's textbook of dermatology. 7th ed. Oxford: Blackwell Science Ltd; 2004. p. 11. 1-11. 25.
11. Häkkinen L, Csiszar A. Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms. J Dent Res. 2007;86(1):25-34.
12. Bayat A, McGrouther DA, Ferguson MW. Skin scarring. BMJ. 2003;326(7380):88-92. (Pubitemid 36092292)
13. Metcalfe AD, Ferguson MW. Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface. 2007;4(14):413-37.
14. Occleston NL, O'Kane S, Goldspink N, Ferguson MW. New therapeutics for the prevention and reduction of scarring. Drug Discov Today. 2008;13(21-22): 973-81. Epub 2008 Oct. 15.
15. Bombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA. et al. What is the prevalence of hypertrophic scarring following burns? Burns. 2003;29(4):299-302. (Pubitemid 36627670)
16. Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359(1445):839-50. (Pubitemid 38673751)
17. Armstrong JR, Ferguson MW. Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica. Dev Biol. 1995;169(1):242-60.
18. Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599-607. Epub 2005 Oct. 3. (Pubitemid 41619424)
19. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127(3):514-25.
20. Bullard KM, Longaker MT, Lorenz HP. Fetal wound healing: current biology. World J Surg. 2003;27(1):54-61. (Pubitemid 36920185)
21. Fang RC, Mustoe TA. Animal models of wound healing: utility in transgenic mice. J Biomater Sci Polym Ed. 2008;19(8):989-1005. (Pubitemid 351957386)
22. Michalopoulos GK, De Frances MC. Liver regeneration. Science. 1997;276(5309):60-6.
23. Stoick-Cooper CL, Moon RT, Weidinger G. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev. 2007;21(11):1292-315. (Pubitemid 46871034)
24. Szpaderska AM, Zuckerman JD, Di Pietro LA. Differential injury responses in oral mucosal and cutaneous wounds. J Dent Res. 2003;82(8):621-6. (Pubitemid 41766145)
25. Schrementi ME, Ferreira AM, Zender C, Di Pietro LA. Site-specific production of TGF-beta in oral mucosal and cutaneous wounds. Wound Repair Regen. 2008;16(1):80-6. Epub 2007 Dec. 13.
26. Chen L, Arbieva ZH, Guo S, Marucha PT, Mustoe TA, Di Pietro LA. Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics. 2010;11:471.
27. Häkkinen L, Uitto VJ, Larjava H. Cell biology of gingival wound healing. Periodontology 2000. 2000;24:127-52.
28. Hart BL, Powell KL. Anti bacterial properties of saliva: role in maternal periparturient grooming and in licking wounds. Physiol Behav. 1990;48(3):383-6. (Pubitemid 20325160)
29. Varshney AC, Sharma DN, Singh M, Sharma SK, Nigam JM. Therapeutic value of bovine saliva in wound healing: a histomorphological study. Indian J Exp Biol. 1997;35(5):535-7. (Pubitemid 28152521)
30. Hutson JM, Niall M, Evans D, Fowler R. Effect of salivary glands on wound contraction in mice. Nature. 1979;279(5716):793-5. (Pubitemid 9202556)
31. Jahovic N, Güzel E, Arbak S, Yegen BC. The healing-promoting effect of saliva on skin burn is mediated by epidermal growth factor (EGF): role of the neutrophils. Burns. 2004;30(6):531-8. (Pubitemid 39099210)
32. Hardwicke J, Schmaljohann D, Boyce D, Thomas D. Epidermal growth factor therapy and wound healing - past, present and future perspectives. Surgeon. 2008;6(3):172-7.
33. Mak K, Manji A, Gallant-Behm C, Wiebe C, Hart DA, Larjava H, et al. Scarless healing of oral mucosa is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model. J Dermatol Sci. 2009;56(3):168-80. Epub 2009 Oct. 24.
34. Wong JW, Gallant-Behm C, Wiebe C, Mak K, Hart DA, Larjava H, et al. Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans. Wound Repair Regen. 2009;17(5):717-29.
35. Wang JF, Olson ME, Reno CR, Kulyk W, Wright JB, Hart DA. Molecular and cell biology of skin wound healing in a pig model. Connect Tissue Res. 2000;41(3):195-211.
36. Wang JF, Olson ME, Reno CR, Wright JB, Hart DA. The pig as a model for excisional skin wound healing: characterization of the molecular and cellular biology, and bacteriology of the healing process. Comp Med. 2001;51(4):341-8. (Pubitemid 32893996)
37. Sullivan TP, Eaglstein WH, Davis SC, Mertz P. The pig as a model for human wound healing. Wound Repair Regen. 2001;9(2):66-76. (Pubitemid 32463294)
38. Gallant CL, Olson ME, Hart DA. Molecular, histologic, and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring. Wound Repair Regen. 2004;12(3):305-19. (Pubitemid 38880439)
39. Zhu KQ, Carrougher GJ, Gibran NS, Isik FF, Engrav LH. Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring. Wound Repair Regen. 2007;15(Suppl 1): S32-9. (Pubitemid 47301672)
40. Gallant-Behm CL, Hildebrand KA, Hart DA. The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs. Wound Repair Regen. 2008;16(2):226-33. (Pubitemid 351342132)
41. Ramos ML, Gragnani A, Ferreira LM. Is there an ideal animal model to study hypertrophic scarring? J Burn Care Res. 2008;29(2):363-8. (Pubitemid 351498833)