Different expression patterns of pAkt, NF-κB and cyclin D1 proteins during the invasion process of head and neck squamous cell carcinoma: An in vitro approach

Journal of Oral Pathology and Medicine

Volumn 40, Issue 5, 2011, Pages 405-411

  Giudice, Fernanda Salgueiredo ^a   Vechio, Aluana Maria da Costa Dal ^a   Abrahão, Aline Corrêa ^a   Sperandio, Felipe Fornias ^a   Pinto Junior, Décio dos Santos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Head and neck squamous cell carcinoma; Invasion process; PI3K Akt signaling pathway

Indexed keywords

CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B;

ARTICLE; CANCER INVASION; CELL CLONE; CONTROLLED STUDY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; LYMPH NODE METASTASIS; PHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STUDENT T TEST; TONGUE CARCINOMA; UPREGULATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CLONE CELLS; CYCLIN D1; CYTOSKELETON; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NF-KAPPA B; PHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TONGUE NEOPLASMS; UP-REGULATION;

EID: 79954556454     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2010.00960.x     Document Type: Article

References (36)

1. Bsoul SA, Huber MA, Terezhalmy GT. Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J Contemp Dent Pract 2005; 6: 1-16.
2. Fidler IJ. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 1978; 38: 2651-60.
3. Bryne M, Koppang HS, Lileng R, Stene T, Bang G, Dabelsteen E. New malignancy grading system is a better prognostic indicator than Broder's grading in oral squamous cell carcinoma. J Oral Pathol Med 1989; 18: 432-7.
4. Monteiro J, Fodde R. Cancer stemness and metastasis: therapeutic consequences and perspectives. Eur J Cancer 2010; 46: 1198-203.
5. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, Van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66: 107-19.
6. Birchmeier W, Hülsken J, Behrens J. E-cadherin as an invasion suppressor. Ciba Found Symp 1995; 189: 124-36.
7. Boyer B, Vallés AM, Edme N. Induction and regulation of epithelial mesenchymal transitions. Biochem Pharmacol 2000; 60: 1091-9.
8. Woodhouse EC, Chuaqui RF, Liotta LA. General mechanisms of metastasis. Cancer 1997; 80: 1529-37.
9. Birchmeier C, Birchmeier W, Brand-Saberi B. Epithelial-mesenchymal transition in cancer progression. Acta Anat 1996; 156: 217-26.
10. Grille SJ, Bellacosa A, Upson J, et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 2003; 63: 2172-8.
11. Kane LP, Shapiro VS, Stokoe D, Weiss A. Induction of NF-kappaB by Akt/PKB kinase. Curr Biol 1999; 9: 601-4.
12. He D, Xu Q, Yan M, et al. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC Cancer 2009; 9: 343.
13. Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS Jr. Selective activation of NF-kappaB subunits in human breast cancer: potential roles for NF-kappaB2/p52 and for Bcl-3. Oncogene 2000; 19: 1123-31.
14. Basseres DS, Baldwin AS. Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 2006; 25: 6817-30.
15. Belguise K, Sonenshein GE. PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis. J Clin Invest 2007; 117: 4009-21.
16. Dordević G, Matusan-Ilijas K, Sinozić E, et al. Relationship Between Vascular Endothelial Growth Factor and Nuclear Factor-kappaB in Renal Cell Tumors. Croat Med J 2008; 49: 608-17.
17. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004; 25: 280-8.
18. Weih F, Caamano J. Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol Rev 2003; 195: 91-105.
19. Papa S, Bubici C, Zazzeroni F, et al. The NF-kappaB mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 2006; 13: 712-29.
20. Witzel II, Koh LF, Perkins ND. Regulation of cyclin D1 gene expression. Biochem Soc Trans 2010; 38: 217-22.
21. Wang R, Brattain MG. Akt can be activated in the nucleus. Cell Signal 2006; 18: 1722-31.
22. Merkhofer EC, Cogswell P, Baldwin AS. Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene 2010; 29: 1238-48.
23. Andjelkovic M, Alessi DR, Meier R, et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997; 272: 31515-24.
24. Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem 1997; 272: 30491-7.
25. Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-95.
26. Fresno Vara JA, Casado E, De Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 2004; 30: 193-204.
27. Meier R, Hemmings BA. Regulation of protein kinase B. J Recept Signal Transduct Res 1999; 19: 121-8.
28. Cardinali M, Pietraszkiewicz H, Ensley JF, Robbins KC. Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies. Int J Cancer 1995; 61: 98-103.
29. Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997; 57: 2124-9.
30. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275: 1943-7.
31. Chin YR, Toker A. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Mol Cell 2010; 38: 333-44.
32. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/Akt pathways. Oncogene 2005; 24: 7443-54.
33. Huber MA, Azoitei N, Baumann B, et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004; 114: 569-81.
34. Julien S, Puig I, Caretti E, et al. Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 2007; 26: 7445-56.
35. Hong KO, Kim JH, Hong JS, et al. Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells. J Exp Clin Cancer Res 2009; 28: 28.
36. Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. NF-kappaB function in growth control: regulation of cyclin Dl expression and G0/G1-to-S-phase transition. Mol Cell Biol 1999; 19: 2690-8.