Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis

Gut

Volumn 55, Issue 4, 2006, Pages 450-456

  Hayakawa, T ^a   Fujiwara, Y ^a   Hamaguchi, M ^a   Sugawa, T ^a   Okuyama, M ^a   Sasaki, E ^a   Watanabe, T ^a   Tominaga, K ^a   Oshitani, N ^a   Higuchi, K ^a   Arakawa, T ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CELL PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MICROSOME ENZYME; NIMESULIDE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E SYNTHASE 2; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEIN EP4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOSOL; DISEASE SEVERITY; DRUG EFFECT; ENZYME LOCALIZATION; EPITHELIUM CELL; ESOPHAGUS MUCOSA; EXPERIMENTAL LIGATION; HISTOPATHOLOGY; INFLAMMATORY CELL; MALE; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; RAT; REFLUX ESOPHAGITIS; TISSUE LEVEL;

ANIMALS; CELL DIVISION; CHRONIC DISEASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOSOL; DINOPROSTONE; EPITHELIAL CELLS; ESOPHAGITIS, PEPTIC; ESOPHAGUS; IMMUNOHISTOCHEMISTRY; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MICROSOMES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E; SULFONAMIDES;

EID: 33645164389     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2005.081943     Document Type: Article

References (32)

1. Chiba N, De Gara G, Wilkinson JM, et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 1997;112:1798-810.
2. Ismail-Beigi F, Horton PF, Pope CEII, et al. Histological consequences of gastroesophageal reflux in men. Gastroenterology 1970;58:163-74.
3. Alber D, Moussard C, Toubin M, et al. Gas chromatographic/mass spectrometric quantitative analysis of eicosanoids in human oesophageal mucosa. Biomed Environ Mass Spectrom 1988;16:299-304.
4. Marcinkiewicz M, Sarosiek J, Edmunds M, et al. Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance. J Clin Gastroenterol 1995;21:268-74.
5. Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 1992;266:7384-8.
6. Murakami M, Nakatani Y, Tanioka T, et al. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat 2002;68-69:383-99.
7. 2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000;275:32783.
8. Trebino CE, Stock JL, Gibbons CP, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003:22, 100:9044-9.
9. Subbaramaiah K, Yoshimatsu K, Scherl E, et al. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Biol Chem 2004;279:12647-58.
10. Omura N, Kashiwagi H, Chen G, et al. Establishment of surgically induced chronic acid reflux esophagitis in rats. Scand J Gastroenterol 1999;34:948-53.
11. Claveau D, Sirinyan M, Guay J, et al. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. J Immunol 2003;170:4738-44.
12. Tanigawa T, Watanabe T, Hamaguchi M, et al. Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2, Am J Physiol Gastrointest Liver Physiol 2004;286:G148-56.
13. Kawabe A, Shimada Y, Soma T, et al. Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophogeal epithelial cells. Life Sci 2004;75:21-34.
14. Hamaguchi M, Fujiwara Y, Takashima T, et al. Increased expression of cytokines and adhesion molecules in rat chronic esophagitis. Digestion 2003;68:189-97.
15. Kaur BS, Khamnehei N, Iravani M, et al. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Gastroenterology 2002;123:60-7.
16. Shirvani VN, Ouatu-Lascar R, Kaur BS, et al. Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. Gastroenterology 2000;118:487-96.
17. Takahashi M, Ota S, Ogura K, et al. Hepatocyte growth factor stimulates wound repair of the rabbit esophageal epithelial cells in primary culture. Biochem Biophys Res Commun 1995;216:298-305.
18. Fujiwara Y, Higuchi K, Hamaguchi M, et al. Increased expression of transforming growth factor-alpha and epidermal growth factor receptors in rat chronic reflux esophagitis. J Gastroenterol Hepatol 2004;19:521-7.
19. Baatar D, Kawanaka H, Szabo IL, et al. Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. Gastroenterology 2002;122:458-68.
20. Eastwood GL, Beck BD, Castell DO, et al. Beneficial effect of indomethacin on acid-induced esophagitis in cats. Dig Dis Sci 1981;26:601-8.
21. Northway MG, Libshitz HI, Osborne BM, et al. Radiation esophagitis in the opossum: radioprotection with indomethacin. Gastroenterology 1980;78:883-92.
22. Lanas A, Jimenez P, Ferrandez A, et al. Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis. Inflammation 2003;27:21-9.
23. Baatar D, Jones MK, Pai R, et al. Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Am J Pathol 2002;160:963-72.
24. Watanabe T, Higuchi K, Tominaga K, et al. Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1beta. Gut 2001;48:774-81.
25. Jang TJ, Min SK, Bae JD, et al. Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux. Gut 2004;53:27-33.
26. Kamei D, Murakami M, Nakatani Y, et al. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J Biol Chem 2003;278:19396-405.
27. Yoshimatsu K, Altorki NK, Golijanin D, et al. Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin Cancer Res 2001;7:2669-74.
28. Trebino CE, Stock JL, Gibbons CP, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A 2003;100:9044-9.
29. Stichtenoth DO, Thoren S, Bian H, et al. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 2001;167:469-74.
30. Ryan P, Hetzel DJ, Shearman DJ, et al. Risk factors for ulcerative reflux oesophagitis: a case-control study. J Gastroenterol Hepatol 1995;10:306-12.
31. Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion 1992;51(Suppl 1):24-9.
32. Hamoui N, Peters JH, Schneider S, et al. Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. Arch Surg 2004;139:712-17.