Clozapine and PD149163 Elevate Prepulse Inhibition in Brown Norway Rats

Behavioral Neuroscience

Volumn 125, Issue 2, 2011, Pages 268-272

  Feifel, David ^a   Shilling, Paul D ^a   Melendez, Gilia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Animal model; Antipsychotic; Neurotensin; Prepulse inhibition; Schizophrenia

Indexed keywords

CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; OPIATE AGONIST; PD 149163; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; NONHUMAN; PREPULSE INHIBITION; RAT; STARTLE REFLEX; SYSTEMIC THERAPY;

ANIMALS; ANTIPSYCHOTIC AGENTS; CLOZAPINE; NEURAL INHIBITION; NEUROTENSIN; RATS; RATS, INBRED BN; STARTLE REACTION;

EID: 79954529856     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/a0022691     Document Type: Article

References (28)

1. Azmi N., Norman C., Spicer C.H., Bennett G.W. Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behavioural Pharmacology 2006, 17:357-362.
2. Braff D.L., Geyer M.A., Swerdlow N.R. Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl) 2001, 156:234-258.
3. Cilia J., Gartlon J.E., Shilliam C., Dawson L.A., Moore S.H., Jones D.N. Further neurochemical and behavioural investigation of Brattleboro rats as a putative model of schizophrenia. Journal of Psychopharmacology 2010, 24:407-419.
4. Conti L.H., Costill J.E., Flynn S., Tayler J.E. Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain. Behavioral Neuroscience 2005, 119:1052-1060.
5. Conti L.H., Palmer A.A., Vanella J.J., Printz M.P. Latent inhibition and conditioning in rat strains which show differential prepulse inhibition. Behavior Genetics 2001, 31:325-333.
6. Conti L.H., Printz M.P. Rat strain-dependent effects of repeated stress on the acoustic startle response. Behavioural Brain Research 2003, 144:11-18.
7. Depoortere R., Perrault G., Sanger D.J. Potentiation of prepulse inhibition of the startle reflex in rats: Pharmacological evaluation of the procedure as a model for detecting antipsychotic activity. Psychopharmacology 1997, 132:366-374.
8. Depoortere R., Perrault G., Sanger D.J. Some, but not all, antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain. Behavioural Pharmacology 1997, 8:364-372.
9. Feifel D., Melendez G., Priebe K., Shilling P.D. The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behavioural Brain Research 2007, 181:278-286.
10. Feifel D., Melendez G., Shilling P.D. A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist. Neuropsychopharmacology 2003, 28:651-653.
11. Feifel D., Melendez G., Shilling P.D. Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: A potential predictive model for novel antipsychotic effects. Neuropsychopharmacology 2004, 29:731-738.
12. Feifel D., Mexal S., Melendez G., Liu P.Y., Goldenberg J.R., Shilling P.D. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology 2009, 34:2011-2018.
13. Feifel D., Minor K.L., Dulawa S., Swerdlow N.R. The effects of intra-accumbens neurotensin on sensorimotor gating. Brain Research 1997, 760:80-84.
14. Feifel D., Pang Z., Shilling P.D., Melendez G., Schreiber R., Button D. Sensorimotor gating in neurotensin-1 receptor null mice. Neuropharmacology 2010, 58:173-178.
15. Feifel D., Priebe K. Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol. Biological Psychiatry 2001, 50:425-433.
16. Feifel D., Reza T.L., Wustrow D.J., Davis M.D. Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. Journal of Pharmacology and Experimental Therapeutics 1999, 288:710-713.
17. Feifel D., Shilling P.D., Melendez G. Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy. Journal of Psychopharmacology 2010, doi: 10.1177/0269881110388327.
18. Geyer M.A., Krebs-Thomson K., Braff D.L., Swerdlow N.R. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review. Psychopharmacology (Berl) 2001, 156:117-154.
19. Kumari V., Sharma T. Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: A critical evaluation of current evidence and directions for future research. Psychopharmacology (Berl) 2002, 162:97-101.
20. Leumann L., Feldon J., Vollenweider F.X., Ludewig K. Effects of typical and atypical antipsychotics on prepulse inhibition and latent inhibition in chronic schizophrenia. Biological Psychiatry 2002, 52:729-739.
21. Mansbach R.S., Geyer M.A., Braff D.L. Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 1988, 94:507-514.
22. Oranje B., Van Oel C.J., Gispen-De Wied C.C., Verbaten M.N., Kahn R.S. Effects of typical and atypical antipsychotics on the prepulse inhibition of the startle reflex in patients with schizophrenia. Journal of Clinical Psychopharmacology 2002, 22:359-365.
23. Palmer A.A., Dulawa S.C., Mottiwala A.A., Conti L.H., Geyer M.A., Printz M.P. Prepulse startle deficit in the Brown Norway Rat: A potential genetic model. Behavioral Neuroscience 2000, 11:374-388.
24. Shilling P.D., Melendez G., Priebe K., Richelson E., Feifel D. Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonist. Psychopharmacology (Berl) 2004, 175:353-359.
25. Swerdlow N.R., Breier M., Mora A.B., Ko D., Shoemaker J.M. A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating. Pharmacology, Biochemistry and Behavior 2008, 88:280-290.
26. Swerdlow N.R., Geyer M.A. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophrenia Bulletin 1998, 24:285-301.
27. Swerdlow N.R., Talledo J., Sutherland A.N., Nagy D., Shoemaker J.M. Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats. Neuropsychopharmacology 2006, 31:2011-2021.
28. Weiss I.C., Feldon J., Domeney A.M. Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine. Pharmacology, Biochemistry and Behavior 1999, 64:501-505.